Results 41 to 50 of about 251,458 (268)
The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome
FEBS Letters, EarlyView.This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley +1 more source
FEBS Letters, EarlyView.The physical dimensions and shape of bacterial cells define the surface area available to acquire nutrients and the volume available for synthesizing proteins and DNA. Here, we use computational systems biology to decode the importance of cell geometry as a major determinant of prokaryotic phenotype, including growth rate and metabolic efficiency. This
Ross P. Carlson +6 more
wiley +1 more source
Uncertainty Measurement for Fuzzy Set-Valued Data
IEEE Access, 2020 Uncertainty measurement (UM) can offer new visual angle for data analysis. A fuzzy set-valued information system (FSVIS) indicates an information system (IS) where its information values are fuzzy sets.
Sichun Wang, Yini Wang, Hongxiang Tang
doaj +1 more source
From mice to humans—divergent strategies for intestinal homeostasis and regeneration
FEBS Letters, EarlyView.Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa +2 more
wiley +1 more source
GelsGlobal demand for sustainable food packaging materials has intensified research on bio-based biopolymer systems capable of delivering functional compounds.
Dimitrie Stoica +4 more
doaj +1 more source
‘What are you going to do, confiscate their passports?’ Professional perspectives on cross-border reproductive travel [PDF]
, 2013 Objective: This article reports findings from a UK-based study which explored the phenomenon of overseas travel for fertility treatment. The first phase of this project aimed to explore how infertility clinicians and others professionally involved in ...
Pacey, Allan +9 more
core +1 more source
FEBS Letters, EarlyView.Drosophila park mutants serve as a model for Parkinson's disease. We used this strain to investigate the connection between oxidative stress and the circadian clock mechanism. We showed that increased oxidative stress affects the physiology of pacemaker cells, disrupting their daily structural plasticity. Lack of rhythmic signaling from pacemaker cells
Kamila Zientara +3 more
wiley +1 more source
The socio-economic impacts of Singaporean cross-border tourism in Malaysia and Indonesia [PDF]
, 2009 Cross-border tourism is often proposed by governments as an incentive for economic growth, but critics have suggested that its impacts are, in fact, overplayed. This paper presents research in the Indonesia-Malaysia-Singapore Growth Triangle.
Hampton, Mark P.
core
α‐Synuclein aggregation landscape from phase separation to neurotoxic intermediates
FEBS Letters, EarlyView.Alpha‐synuclein aggregation in Parkinson's disease involves a complex landscape of transient intermediates, including oligomers, fibrils and liquid–liquid phase separation (LLPS). A view is emerging in which LLPS maturation into solid‐like condensates may contribute to the formation of neurotoxic species.
Silvia Arino +2 more
wiley +1 more source
Transportation Research Interdisciplinary PerspectivesLand-border crossings between Canada and the United States facilitate the movement of approximately 59 % of the goods traded between the two countries. Consequently, these border facilities experience heavy truck traffic daily.
Hanna Maoh, Sidra Anis
doaj +1 more source