Results 91 to 100 of about 4,913,448 (310)

Wally and the Major [picture] : at cross purposes /

, 1967
Part of the Stan Cross Archive of cartoons and drawings, 1912-1974.; Inscription: "Stan Cross 7/87"--In ink, lower right. "8335 Thur Apr 13 At Cross Purposes"--In ink, right margin; "8335"--In pencil, upper right corner.; Also available in an electronic ...
Cross, Stan, 1888-1977.
core  

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Palladium-catalyzed cross coupling reactions of 4-bromo-6H-1,2-oxazines

Beilstein Journal of Organic Chemistry, 2009
A number of 4-aryl- and 4-alkynyl-substituted 6H-1,2-oxazines 8 and 9 have been prepared in good yields via cross coupling reactions of halogenated precursors 2, which in turn are easily accessible by bromination of 6H-1,2-oxazines 1. Lewis-acid promoted
Reinhold Zimmer, Elmar Schmidt, Michal Andrä, Marcel-Antoine Duhs, Igor Linder, Hans-Ulrich Reissig   +5 more
doaj   +1 more source

Wally and the Major [picture] : at cross purposes /

, 1969
Part of the Stan Cross Archive of cartoons and drawings, 1912-1974.; Inscription: "Stan Cross 9/80"--In ink, lower right. "8953 Tue Apr 8. At Cross Purposes"--In ink, right margin; "8953"--In pencil, upper right corner.; Also available in an electronic ...
Cross, Stan, 1888-1977.
core  

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Enabling Nickel‐Catalyzed Suzuki–Miyaura Cross‐Coupling of Carbamoyl Fluorides: Mechanism and Scope

ChemistryEurope
The first Ni‐catalyzed Suzuki cross‐coupling amide synthesis using stable carbamoyl fluoride starting materials under mild conditions is reported. Mechanistic studies are carried out to document the reactivity of nickel toward the CF bond oxidative ...
Lulu Han, Viktor Boshevski, Yi Yang, Dan Louvel, Margherita Colombo, Gaël Tran, Emmanuel Lacôte, Abderrahmane Amgoune, Anis Tlili   +8 more
doaj   +1 more source

Photochemical Carbosulfonylative Cross-Coupling of Alkenes

Organic & Biomolecular Chemistry
An alkylative carbosulfonylation protocol for the formation of C-S and C-C bonds between sulfinate salts and readily available alkenes under visible light irradiation is reported. This approach formally couples two alkene molecules to give access to highly functionalized sp3 sulfone products following two sequential radical additions. Homocoupled
Vanessa E. Becker, Mandapati Bhargava Reddy, Eoghan M. McGarrigle   +2 more
openaire   +2 more sources

Nickel-Catalyzed Cross Coupling of Umpolung Carbonyls and Alkyl Halides [PDF]

, 2019
An effective nickel-catalyzed cross coupling of umpolung carbonyls and alkyl halides was developed. Contrary to classical alkylation techniques, this reaction utilizes umpolung carbonyls as the environmentally benign alkyl nucleophiles, providing an ...
Leiyang, Lv, Chao-Jun, Li, Zihang, Qiu, Dianhu, Zhu   +3 more
core   +2 more sources

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source