Results 71 to 80 of about 4,913,448 (310)
FEBS Letters, EarlyView.This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee +2 more
wiley +1 more source
Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network
FEBS Letters, EarlyView.Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley +1 more source
Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source
Wally and the Major [picture] : cross purposes /
, 1958 Part of the Stan Cross Archive of cartoons and drawings, 1912-1974.; Inscription: "Stan Cross 8/47"--Lower right. "5496 Mon Mar 10 Cross Purposes"--In ink, right margin; "5419"--In ink, upper right corner; "11"--In pencil, upper left corner.; Also ...
Cross, Stan, 1888-1977.
core
Emerging experimental and computational methods for studying redox‐regulated structural transitions
FEBS Letters, EarlyView.Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass +2 more
wiley +1 more source
Wally and the Major [picture] : cross purposes /
, 1970 Part of the Stan Cross Archive of cartoons and drawings, 1912-1974.; Inscription: "Stan Cross 70/24"--In ink, lower right. "9205 Wed Jan 28. Cross Purposes"--In ink, right margin; "9205"--In pencil, upper right corner.; Also available in an electronic ...
Cross, Stan, 1888-1977.
core
A Systematic Investigation into Bisphosphine Ligands for Nickel-Catalyzed C(sp2)–N Cross-Coupling
, 2023 Research into transition metal-catalyzed C–N cross-coupling reactions has been driven by a need for robust and facile synthetic routes towards bioactive molecules which are rich in C–N linkages. The use of Pd-based catalysts in Buchwald-Hartwig Amination
Martinek, Nicole
core
Translophagy—A potential link between autophagy impairment and translational errors
FEBS Letters, EarlyView.Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk +11 more
wiley +1 more source
The Current Status of Heterogeneous Palladium Catalysed Heck and Suzuki Cross-Coupling Reactions
Molecules, 2018 In the last 30 years, C–C cross coupling reactions have become a reliable technique in organic synthesis due their versatility and efficiency. While drawbacks have been experienced on an industrial scale with the use of homogenous systems, many ...
Philani P. Mpungose +3 more
doaj +1 more source
Wally and the Major [picture] : cross purposes /
, 1968 Part of the Stan Cross Archive of cartoons and drawings, 1912-1974.; Inscription: "Stan Cross 8/195"--In ink, lower right. "8757 Fri Aug 16 Cross Purposes"--In ink, right margin; "8757"--In pencil, upper right corner; "6"--In pencil, upper left corner ...
Cross, Stan, 1888-1977.
core