Results 81 to 90 of about 285,996 (265)

Enabling Nickel‐Catalyzed Suzuki–Miyaura Cross‐Coupling of Carbamoyl Fluorides: Mechanism and Scope

ChemistryEurope
The first Ni‐catalyzed Suzuki cross‐coupling amide synthesis using stable carbamoyl fluoride starting materials under mild conditions is reported. Mechanistic studies are carried out to document the reactivity of nickel toward the CF bond oxidative ...
Lulu Han, Viktor Boshevski, Yi Yang, Dan Louvel, Margherita Colombo, Gaël Tran, Emmanuel Lacôte, Abderrahmane Amgoune, Anis Tlili   +8 more
doaj   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

A Decade of Exploration of Transition-Metal-Catalyzed Cross-Coupling Reactions: An Overview

SynOpen, 2023
Saurav Kumar, Jyoti Jyoti, Deepak Gupta, Gajendra Singh, Anil Kumar   +4 more
doaj   +1 more source

Weakly-Activated Phenol Derivatives as New Green Electrophilic Partners in Suzuki–Miyaura and Related C-C Couplings

Molecules
In recent years, there has been growing interest in the development of greener alternatives to traditional reagents used in carbon–carbon coupling reactions, particularly in response to environmental concerns.
Jules Perney, Alexandre Humblot-Negri, Carlos Vaca-Garcia, Sébastien Lemouzy, Martine Urrutigoïty   +4 more
doaj   +1 more source

Photochemical Carbosulfonylative Cross-Coupling of Alkenes

Organic & Biomolecular Chemistry
An alkylative carbosulfonylation protocol for the formation of C-S and C-C bonds between sulfinate salts and readily available alkenes under visible light irradiation is reported. This approach formally couples two alkene molecules to give access to highly functionalized sp3 sulfone products following two sequential radical additions. Homocoupled
Vanessa E. Becker, Mandapati Bhargava Reddy, Eoghan M. McGarrigle   +2 more
openaire   +2 more sources

Effects of IGFBP4 deficiency on human preadipocyte proliferation and differentiation through the IGF1R/AKT pathway

FEBS Open Bio, EarlyView.
IGFBP4 knockdown (KD) impairs preadipocyte proliferation and is associated with IGF1R protein downregulation and attenuated AKT phosphorylation. The mechanisms by which IGFBP4 KD influences the IGF1R/AKT signaling pathway involve newly synthesized proteins and lysosomal degradation pathways. Created in BioRender.
Yujia Guo, Sandy Richter, Christoph Bach, Wieland Kiess, Anna Kirstein, Diana Le Duc, Antje Garten   +6 more
wiley   +1 more source

Importin 7 mediates the nuclear import of HIV‐1 integrase via a specific interacting interface

FEBS Open Bio, EarlyView.
HIV‐1 integrase enables viral DNA integration into the host genome. By binding to the core domain of the host protein Importin 7 via its C‐terminal domain, the integrase is transported across the nuclear membrane into the nucleus, where integration of the viral genome into host DNA takes place. This translocation is a critical step for subsequent viral
Juana Bana, Avigail Yariv, Tal Oppenheim, Hadar Amartely, Dana Reichmann, Oded Livnah   +5 more
wiley   +1 more source

Photoredox-Catalyzed Decarboxylative Cross-Coupling Reaction to Synthesis Unsymmetrical Diarylmethanes

Molecules
The photoredox-catalyzed decarboxylative cross-coupling reaction of aryl acetic acids and aryl nitriles has been achieved under an argon atmosphere in high yields.
Guozhe Guo, Yuquan Zhang, Yanchun Li, Zhijun Li   +3 more
doaj   +1 more source

Accurate and noninvasive prostate cancer detection using plasma‐derived extracellular vesicle RNA

FEBS Open Bio, EarlyView.
Plasma extracellular vesicles were captured with WGA‐conjugated magnetic beads and profiled for RNA biomarkers. A three‐RNA panel (NM_024955, NR_047469, and NR_002564) distinguished prostate cancer from healthy controls and benign prostatic hyperplasia, supporting a simple, noninvasive approach to improve prostate cancer detection.
Hanping Wei, Haoran Wu, Wei Feng
wiley   +1 more source

Adenosine triphosphate as a modulator of protein interactions and stability

FEBS Open Bio, EarlyView.
ATP is best known as the cell's energy currency, but it also shapes how proteins fold, interact, aggregate and form biomolecular condensates. This review explains the emerging physical principles behind these effects, including weak binding to charged protein regions, magnesium‐dependent behaviour and concentration‐dependent control of protein ...
Shuyuan Tan, Robin Curtis
wiley   +1 more source