Results 61 to 70 of about 4,913,448 (310)
FEBS Letters, EarlyView.Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas +4 more
wiley +1 more source
New insight in Hiyama cross-coupling reactions: Decarboxylative, denitrogenative and desulfidative couplings [PDF]
Chemical Review and Letters, 2018 In this mini-review, recent advances and developments in the decarboxylative, denitrogenative, and desulfidative Hiyama-type cross-coupling reaction from 2011 up present are studied.
Shahriar Sarhandi +4 more
doaj +1 more source
Journal of the American Chemical SocietyA fundamental property of cross-coupling reactions is regiospecificity, meaning that the site of bond formation is determined by the leaving group’s location on the electrophile. Typically, to achieve a different substitution pattern requires synthesis of a new, corresponding starting-material isomer.
Yoshiya Sekiguchi +3 more
openaire +2 more sources
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Liver organoids: modelling complexity in homeostasis and disease
FEBS Letters, EarlyView.Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley +1 more source
Research on coordinated control of support system of magnetoelectric hybrid suspension belt conveyor
Meitan xuebaoA magnetoelectric hybrid suspension belt conveyor is introduced as a novel type of continuous transportation equipment characterized by low resistance and low energy consumption.
Kun HU +4 more
doaj +1 more source
Epigenetic reprogramming of lineage switching in cancer
FEBS Letters, EarlyView.Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı +4 more
wiley +1 more source
, 1954 Part of the Stan Cross Archive of cartoons and drawings, 1912-1974.; Two copies of original drawing. "Merry Xmas and a Happy New Year From Stan Cross and his Family December 1954"; Also available in an electronic version via the internet at: http://nla ...
Cross, Stan, 1888-1977.
core +2 more sources
Introduction of peripheral nitrogen atoms to cyclo-meta-phenylenes
Beilstein Journal of Organic ChemistryCyclo-meta-phenylenes doped with nitrogen atoms at the periphery were designed and synthesized. The syntheses of the macrocyclic structures were achieved with one-pot Suzuki–Miyaura coupling to arrange phenylene rings and pyridinylene rings in an ...
Koki Ikemoto, Hiroyuki Isobe
doaj +1 more source
A neural mass model of cross frequency coupling. [PDF]
PLoS ONE, 2017 Electrophysiological signals of cortical activity show a range of possible frequency and amplitude modulations, both within and across regions, collectively known as cross-frequency coupling.
Mojtaba Chehelcheraghi +3 more
doaj +1 more source