Results 51 to 60 of about 2,676,134 (279)

Fast Cross-Validation [PDF]

open access: yesProceedings of the Twenty-Seventh International Joint Conference on Artificial Intelligence, 2018
Cross-validation (CV) is the most widely adopted approach for selecting the optimal model. However, the computation of CV  has high complexity due to multiple times of learner training, making it disabled for large scale model selection. In this paper, we present an approximate approach to CV based on the theoretical notion of Bouligand influence ...
Yong Liu   +4 more
openaire   +1 more source

‘They Need to Hear You Say It’: Healthcare Professionals’ Perspectives on Barriers and Enablers to End‐of‐Life Discussions With Adolescents and Young Adults With Cancer

open access: yesPediatric Blood &Cancer, EarlyView.
ABSTRACT End‐of‐life conversations with adolescents and young adults (AYAs) with cancer rarely occur without the guidance of healthcare professionals. As a part of the ‘Difficult Discussions’ study, focused on palliative care and advance care planning discussions with AYAs with cancer, we investigated the factors that healthcare professionals identify ...
Justine Lee   +9 more
wiley   +1 more source

Therapeutic Apheresis for Intravenous Methylprednisolone‐Refractory Neuromyelitis Optica Spectrum Disorder: Clinical and Radiological Outcomes in a Single‐Center Case Series

open access: yesTherapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Background Neuromyelitis optica spectrum disorder (NMOSD) is a relapsing autoimmune disease of the central nervous system. High‐dose intravenous methylprednisolone (IVMP) is the standard first‐line therapy for acute attacks, although some patients remain refractory.
Wataru Horiguchi   +5 more
wiley   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

open access: yesFEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho   +3 more
wiley   +1 more source

Analysis of color features performance using support vector machine with multi-kernel for batik classification

open access: yesIJAIN (International Journal of Advances in Intelligent Informatics), 2022
Batik is a sort of cultural heritage fabric that originated in many areas of Indonesia. It can be traced back to many different parts of Indonesia. Each region, particularly Semarang in Central Java, Indonesia, has its Batik design. Unfortunately, due to
Edy Winarno   +3 more
doaj   +1 more source

Cross-level Validation of Topological Quantum Circuits

open access: yes, 2014
Quantum computing promises a new approach to solving difficult computational problems, and the quest of building a quantum computer has started. While the first attempts on construction were succesful, scalability has never been achieved, due to the ...
A. Fowler   +4 more
core   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

open access: yesFEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe   +3 more
wiley   +1 more source

Multiplicative local linear hazard estimation and best one-sided cross-validation [PDF]

open access: yes, 2017
This paper develops detailed mathematical statistical theory of a new class of cross-validation techniques of local linear kernel hazards and their multiplicative bias corrections.
Gámiz Pérez, M. L.   +2 more
core   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

Sequential Data-Adaptive Bandwidth Selection by Cross-Validation for Nonparametric Prediction

open access: yes, 2010
We consider the problem of bandwidth selection by cross-validation from a sequential point of view in a nonparametric regression model. Having in mind that in applications one often aims at estimation, prediction and change detection simultaneously, we ...
Ansgar Steland   +7 more
core   +1 more source

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