Results 71 to 80 of about 2,676,134 (279)
Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source
Breast Cancer Diagnosis Using Machine Learning and PSO
Tehnički GlasnikHealthcare systems around the world are facing huge challenges in responding to trends of the rise of chronic diseases. Early detection of breast cancer is essential for successful treatment since it is a common and potentially fatal condition.
Sarita Silaich, Rajesh Yadav
doaj +1 more source
Agronomy, 2020 Genomic selection (GS) is being applied routinely in wheat breeding programs. For the evaluation of preliminary lines, this tool is becoming important because preliminary lines are generally evaluated in few environments with no replications due to the ...
Virginia L. Verges +1 more
doaj +1 more source
Fetal Brain Tumor Harboring a Unique ROCK1::BRAF Fusion
Pediatric Blood &Cancer, EarlyView.
Marllon Cindra Sant'Ana +8 more
wiley +1 more source
Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
DesimalThe Brown and Holt DES method effectively captures trends in time-series data. Its forecasting accuracy heavily depends on the selection of optimal smoothing parameters. Often, the smoothing parameters are selected manually using trial and error methods.
Chelsea Fatihah Rahma +3 more
doaj +1 more source
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
Bridging scales: integrated multi-omics and deep phenotyping for climate resilience in crop plants
Frontiers in Plant ScienceGlobal changes in agricultural and environmental systems will necessitate new crop research methodologies in the future years to ensure more effective use of natural resources and food security.
Sreekumar Anand +8 more
doaj +1 more source
Cross-Validation Without Doing Cross-Validation in Genome-Enabled Prediction
G3 Genes|Genomes|Genetics, 2016 AbstractCross-validation of methods is an essential component of genome-enabled prediction of complex traits. We develop formulae for computing the predictions that would be obtained when one or several cases are removed in the training process, to become members of testing sets, but by running the model using all observations only once.
Daniel Gianola, Chris-Carolin Schön
openaire +3 more sources
Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition
Molecular Oncology, EarlyView.We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li +10 more
wiley +1 more source