Results 131 to 140 of about 122,193 (311)
Characteristics and outcomes of *ABxNA crosses, RAD-tag sequencing, and genetic mapping.
, 2012 Characteristics and outcomes of *ABxNA crosses, RAD-tag sequencing, and genetic mapping.
Paul Hohenlohe (152939) +6 more
core +1 more source
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Domestication of wild roses for fruit production [PDF]
, 2004 The utilization of rose hips has a long tradition in Sweden, where they are used for the manufacturing of a popular dessert soup rich in vitamin C. In the mid 1980s a project was initiated at Balsgård, situated in the south of Sweden, with the aim to ...
Uggla, Madeleine
core
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Epistasis: obstacle or advantage for mapping complex traits?
, 2010 Identification of genetic loci in complex traits has focused largely on one-dimensional genome scans to search for associations between single markers and the phenotype.
George Casella +7 more
core +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Genetic Programming Crossover: Does It Cross over? [PDF]
, 2009 One justification for the use of crossover operators in Genetic Programming is that the crossover of program syntax gives rise to the crossover of information at the semantic level. In particular, a fitness-increasing crossover is presumed to act by combining fitness-contributing components of both parents.
openaire +1 more source
Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma
Molecular Oncology, EarlyView.Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski +10 more
wiley +1 more source
Genetics of Interracial Crosses in Hawaii [PDF]
Journal of Medical Genetics, 1967 N.E. Morton, C.S. Chung, M.P. Mi
openaire +2 more sources
Molecular Oncology, EarlyView.Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim +3 more
wiley +1 more source