Results 111 to 120 of about 263,045 (309)
The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity
Molecular Oncology, EarlyView.Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli +7 more
wiley +1 more source
Genetic Recombination in Bacteriophage {varphi}X174 [PDF]
, 1974 Genetic recombination in bacteriophage {varphi}X174 usually takes place early in the infection process and involves two parental replicative form (double-stranded) DNA molecules.
Benbow, Robert M. +3 more
core
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Milk Composition for Admixed Dairy Cattle in Tanzania
Frontiers in Genetics, 2018 It is well established that milk composition is affected by the breed and genotype of a cow. The present study investigated the relationship between the proportion of exotic genes and milk composition in Tanzanian crossbred dairy cows.
Evans K. Cheruiyot +5 more
doaj +1 more source
Inbreeding Affects on Beetle Clustering [PDF]
, 2018 The Red Flour Beetle (Tribolium castaneum; Coleoptera: Tenebrionidae) is a common pest in many grain mills (Baldwin and Fasulo 2010) and found wherever grains or other dried foods are stored (Schröder 2008).
Key, Morgan, Marshall, Jeremy
core
Molecular Oncology, EarlyView.Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson +9 more
wiley +1 more source
Molecular Oncology, EarlyView.Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen +11 more
wiley +1 more source
Genetic base and origin of cytoplasmic genes of Brazilian cowpea cultivars
Crop Breeding and Applied BiotechnologyThe expansion of cowpea (Vigna unguiculata (L.) Walp.) crop has created new demands for its breeding programs. Knowledge of its genetic base is fundamental for choosing progenitors when conducting crosses. This study aimed to estimate the genetic base of
Marcos Garreto Meireles +4 more
doaj
Molecular Oncology, EarlyView.Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau +36 more
wiley +1 more source
Silva Fennica, 2012 Hybrid aspen (Populus tremula L. Populus tremuloides Michx.) plantations are expanding in Fennoscandia and the Baltic countries; however, the possible effects of plantations on the native European aspen (P.
Koivuranta, Leena +2 more
doaj +1 more source