Results 101 to 110 of about 2,124,367 (296)

A survey of genetic improvement search spaces [PDF]

, 2019
Genetic Improvement (GI) uses automated search to improve existing software. Most GI work has focused on empirical studies that successfully apply GI to improve software's running time, fix bugs, add new features, etc. There has been little research into
Alexander, B, Petke, Justyna, Alexander, Brad, Petke, J, White, DR, Wagner, M., Barr, ET, White, David R, Wagner, M, Barr, Earl T, Alexander, B., White, D.R., Petke, J., Barr, E.T., Brownlee, AEI, Brownlee, Alexander E I, Wagner, Markus, Brownlee, A.E.I.   +17 more
core   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Evidence for the Emergence of New Rice Types of Interspecific Hybrid Origin in West African Farmers' Fields [PDF]

, 2009
In West Africa two rice species (Oryza glaberrima Steud. and Oryza sativa L.) co-exist. Although originally it was thought that interspecific hybridization is impossible without biotechnological methods, progenies of hybridization appear to occur in ...
Richards, P., Okry, F., Paul Richards, Edwin Nuijten, Nuijten, H.A.C.P., Okry Florent, Richards Paul, Struik, P.C., Struik Paul C., Mokuwa, G.A., Teeken Béla, Mokuwa Alfred, Treuren, R., van, Teeken, B.W.E., van Treuren Robbert, Béla Teeken, van Treuren, R., Robbert van Treuren, Paul C Struik, Alfred Mokuwa, Nuijten Edwin, Florent Okry   +21 more
core   +2 more sources

Genomic-inferred cross-selection methods for multi-trait improvement in a recurrent selection breeding program

Plant Methods
The major drawback to the implementation of genomic selection in a breeding program lies in long-term decrease in additive genetic variance, which is a trade-off for rapid genetic improvement in short term.
Sikiru Adeniyi Atanda, Nonoy Bandillo
doaj   +1 more source

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Inheritance of resistance to Cotton leaf curl virus in cotton (Gossypium hirsutum L.)

Plant Protection Science, 2007
Resistance to Cotton leaf curl virus (CLCuV) in three cultivars of cotton was investigated in crosses with a susceptible cultivar using generation mean analysis.
Azeem Iqbal Khan, Manzoor Hussain, Saeed Rauf, Tariq Manzoor Khan   +3 more
doaj   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

Genetic variability, correlation and path coefficient studies in F2 generation of aerobic rice (Orzya sativa L. ) [PDF]

Electronic Journal of Plant Breeding, 2012
The F2 segregating populations of two crosses viz., cross I (BPT 5204 × JBT 36/14) and Cross II (KMP 148 × JBT 36/14) of rice were evaluated to assess the genetic variability, correlation and direct and indirect effects among yield and yield components ...
Ratnakar Manjunath Shet, Rajanna M P, Ramesh S, Sheshshayee M S and Mahadevu P
doaj