Results 151 to 160 of about 6,733,316 (280)

Engineering tandem VHHs to target different epitopes to enhance antibody‐dependent cell‐mediated cytotoxicity

FEBS Open Bio, EarlyView.
Tandem VHH targeting distinct EGFR epitopes were engineered into a monovalent bispecific antibody (7D12‐EGA1‐Fc) with more potent ADCC without increasing affinity to EGFR. Structural modeling of 7D12‐EGA1‐Fc showed cross‐linking of separate EGFR domains to enhance CD16a engagement on NK cells.
Yuqiang Xu, Hao Jiang, Limin Chen, Fulai Zhou, Ying Jin, Mark L. Chiu   +5 more
wiley   +1 more source

Genome-shock deletion of a hybrid lethality gene breaks a reproductive barrier and facilitates speciation in <i>Nicotiana</i>. [PDF]

Front Plant Sci
Nagai S, Kawaguchi K, Itakura H, Matsumoto K, Iizuka T, Kobayashi K, Nakata K, Yamada T, Marubashi W, Yanase M, Morikawa T, Yokoi S, Tezuka T.   +12 more
europepmc   +1 more source

KLK7 overexpression promotes an aggressive phenotype and facilitates peritoneal dissemination in colorectal cancer cells

FEBS Open Bio, EarlyView.
KLK7, a tissue kallikrein‐related peptidase, is elevated in advanced colorectal cancer and associated with shorter survival. High KLK7 levels in ascites correlate with peritoneal metastasis. In mice, KLK7 overexpression increases metastasis. In vitro, KLK7 enhances cancer cell proliferation, migration, adhesion, and spheroid formation, driving ...
Yosr Z. Haffani, Tobias Dreyer, Meriem Naim, Rea Lo Dico, Natalia A. Ignatenko, Viktor Magdolen, Dalila Darmoul   +6 more
wiley   +1 more source

Pre-breeding efforts through introgression of pre-harvest sprouting resistance genes from wild <i>Vigna radiata</i> var. <i>sublobata</i> into cultivated mungbean. [PDF]

Front Plant Sci
Patil DK, Dhare SL, Gite VK, Kalpande HV, Thakur NR, Pratap A, Baig KS, Ahire RD.   +7 more
europepmc   +1 more source

Domain associated with zinc fingers‐containing NF90‐NF45 complex inhibits m6A modification of primary microRNA by suppressing METTL3/14 activity

FEBS Open Bio, EarlyView.
NF90–NF45 functions as a negative regulator of methyltransferase‐like 3/14 (METTL3/14)‐mediated N6‐methyladenosine (m6A) modification on primary microRNAs (pri‐miRNAs). NF90–NF45 binds to anti‐oncogenic pri‐miRNAs and inhibits their m6A modification, thereby suppressing the biogenesis of anti‐oncogenic miRNAs.
Takuma Higuchi, Shunsuke Morioka, Keiko Morisawa, Kazutsugu Matsukawa, Shingo Ashida, Takeshi Suzuki, Shuji Sakamoto   +6 more
wiley   +1 more source

Mating and Pathogenicity of the Dominant <i>Colletotrichum</i> Species Associated with Anthracnose Disease of Mango. [PDF]

J Fungi (Basel)
Wang R, Cheng H, Shu J, Huang S, Tang L, Guo T, Chen X, Hsiang T, Li Q.   +8 more
europepmc   +1 more source

Polarization‐resolved femtosecond Vis/IR spectroscopy tailored for resolving weak signals in biological samples using minimal sample volume

FEBS Open Bio, EarlyView.
Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley   +1 more source

Heterosis and combining ability analysis of Phytophthora capsici induced root rot resistance and horticultural traits in Capsicum annuum. [PDF]

Sci Rep
Ali MU, Munawar M, Atiq M, Atif RM, Usman M, Khan W, Iqbal O, Rajput NA, Ali Q.   +8 more
europepmc   +1 more source

The role of lipid metabolism in neuronal senescence

FEBS Open Bio, EarlyView.
Disrupted lipid metabolism, through alterations in lipid species or lipid droplet accumulation, can drive neuronal senescence. However, lipid dyshomeostasis can also occur alongside neuronal senescence, further amplifying tissue damage. Delineating how lipid‐induced senescence emerges in neurons and glial cells, and how it contributes to ageing and ...
Dikaia Tsagkari, Eleftheria Panagiotidou, Nektarios Tavernarakis   +2 more
wiley   +1 more source

Accumulation of <i>ph1</i> (<i>zip4-5B</i>) and <i>ph2</i> (<i>msh7-3D</i>) mutations fails to boost homoeologous recombination in hexaploid wheat. [PDF]

Front Plant Sci
Haquet C, Nadaud I, Martin AC, Rey MD, Ben Bouslah A, John-Bejai C, Moore G, Sourdille P.   +7 more
europepmc   +1 more source