Results 161 to 170 of about 6,733,316 (280)

Microglial dynamics and ferroptosis induction in human iPSC‐derived neuron–astrocyte–microglia tri‐cultures

FEBS Open Bio, EarlyView.
A tri‐culture of iPSC‐derived neurons, astrocytes, and microglia treated with ferroptosis inducers as an Induced ferroptosis model was characterized by scRNA‐seq, cell survival, and cytokine release assays. This analysis revealed diverse microglial transcriptomic changes, indicating that the system captures key aspects of the complex cellular ...
Hongmei Lisa Li, Hiroko Ohmiya, Sou Sakamoto, Masato Yugami, Akiko Oki, Makoto Furusawa, Yan Ling   +6 more
wiley   +1 more source

Evolution of dominance in a Mendelian trait is linked to the evolution of environmental plasticity. [PDF]

Evolution
Fukutomi Y, Phillips-Garcia A, Liu J, Chuang A, Watada M, Ramniwas S, Kopp A.   +6 more
europepmc   +1 more source

HIV‐1 establishes immediate latency in T cells expressing the viral Nef protein

FEBS Open Bio, EarlyView.
Nef is a viral protein often omitted from HIV‐1 reporter viruses. Consequently, its role in viral latency is unclear. We developed three novel dual reporter HIV‐1 derivatives that express Nef and allow for detection of latent and productive infection. Using these reporters, we show that Nef does not affect the establishment of immediate viral latency ...
Cindy Lam, Ivan Sadowski
wiley   +1 more source

Epistasis: Searching for Interacting Genetic Variants Using Crosses

G3: Genes, Genomes, Genetics, 2017
Ian M. Ehrenreich
doaj   +1 more source

Creating New Forms of Hexaploid Triticale Associating Complete R and D Genomes. [PDF]

Biology (Basel)
Bernard M, Bernard S, Badaeva E, Schlegel R.   +3 more
europepmc   +1 more source

Within/between population crosses reveal genetic basis for siring success in Silene latifolia (Caryophyllaceae)

Journal of Evolutionary Biology, 2007
C. Jolivet, C. Jolivet, G. Bernasconi, G. Bernasconi   +3 more
semanticscholar   +1 more source

Dihydroorotate dehydrogenase (DHODH) regulates trophoblast syncytialization through organelle stress–induced cellular senescence

FEBS Open Bio, EarlyView.
The inhibition of mitochondrial dihydroorotate dehydrogenase (DHODH) impairs syncytialization and induces cellular senescence via mitochondrial and endoplasmic reticulum stress in human trophoblast stem cells, elevating sFlt1/PlGF levels, a hallmark of placental dysfunction in hypertensive disorders of pregnancy.
Kanoko Yoshida, Kazuya Kusama, Ayaka Horiuchi, Yu Kawaguchi, Atsuya Tsuru, Mikihiro Yoshie, Kazuhiro Tamura   +6 more
wiley   +1 more source

Discovery of Genetically Distinct, Sympatric Coral Lineages With Temporal but Not Gametic Reproductive Isolation. [PDF]

Mol Ecol
Chamberland VF, Gómez-Corrales M, Marhaver KL, Bongaerts P, Latijnhouwers KRW, Vergara-Flórez DC, Snowden S, Sánchez JA, Vermeij MJA.   +8 more
europepmc   +1 more source

Genetic Recombination in Crosses Between Streptomyces aureofaciens and Streptomyces rimosus

Journal of Bacteriology, 1966
M. Polsinelli, M. Beretta
semanticscholar   +1 more source

Patatin‐domain‐containing (phospho)lipases under control: Mammalian co‐regulators and pathogenic activation mechanisms

FEBS Open Bio, EarlyView.
Patatin domain‐containing (phospho)lipases are lipid‐hydrolyzing enzymes central to metabolism, membrane remodeling, and signaling. Their activity relies on precise co‐activation mechanisms involving protein–protein interactions and conformational rearrangements.
Noopur Dubey, Lina Riegler‐Berket, Monika Oberer   +2 more
wiley   +1 more source