Results 91 to 100 of about 11,183,836 (302)

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

open access: yesFEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka   +11 more
wiley   +1 more source

On k-planar crossing numbers

open access: yesDiscrete Applied Mathematics, 2007
The \(k\)-planar crossing number of a graph \(G\), denoted by \(\text{cr}_k(G)\), is the minimum number of crossings of its edges over all possible drawings of the \(G\) in \(k\) planes. This parameter is related to the thickness parameter: \(\text{cr}_k(G)= 0\) if and only if \(G\) has thickness at most \(k\).
Shahrokhi, Farhad   +3 more
openaire   +2 more sources

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

The Crossing Numbers of Products of Path with Graphs of Order Six

open access: yesDiscussiones Mathematicae Graph Theory, 2013
The crossing numbers of Cartesian products of paths, cycles or stars with all graphs of order at most four are known. For the path Pn of length n, the crossing numbers of Cartesian products G⃞Pn for all connected graphs G on five vertices are also known.
Klešč Marián, Petrillová Jana
doaj   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Mechanisms of IgE‐mediated food allergy and the role of allergen‐specific B cells

open access: yesFEBS Letters, EarlyView.
Food allergy arises when allergen‐specific B cells preferentially produce immunoglobulin E (IgE) antibodies against harmless foods. This article explains the mechanisms driving IgE‐mediated reactions, highlights the central role of these B cells, and discusses how natural tolerance (NT) and oral immunotherapy (OIT) can reshape allergic immune responses.
Juan‐Felipe López   +2 more
wiley   +1 more source

Crossing Number Graphs

open access: yesThe Mathematica Journal, 2009
In 1940, the Hungarian mathematician Paul Turan was sent to a forced labor camp by the Nazis. Though every part of his life was brutally controlled, he still managed to do serious mathematics under the most extreme conditions. While forced to collect wire from former neighborhoods, he would be thinking about mathematics.
openaire   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

open access: yesFEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto   +3 more
wiley   +1 more source

Nonplanarity of Iterated Line Graphs

open access: yesJournal of Mathematics, 2020
The 1-crossing index of a graph G is the smallest integer k such that the kth iterated line graph of G has crossing number greater than 1. In this paper, we show that the 1-crossing index of a graph is either infinite or it is at most 5.
Jing Wang
doaj   +1 more source

Projective Cross-ratio on Hypercomplex Numbers [PDF]

open access: yesAdvances in Applied Clifford Algebras, 2012
The paper presents a new cross-ratio of hypercomplex numbers based on projective geometry. We discuss the essential properties of the projective cross-ratio, notably its invariance under Mobius transformations. Applications to the geometry of conic sections and Mobius-invariant metrics on the upper half-plane are also given.
openaire   +2 more sources

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