Results 91 to 100 of about 1,286,422 (323)

Exploring lipid diversity and minimalism to define membrane requirements for synthetic cells

open access: yesFEBS Letters, EarlyView.
Designing the lipid membrane of synthetic cells is a complex task, in which its various roles (among them solute transport, membrane protein support, and self‐replication) should all be integrated. In this review, we report the latest top‐down and bottom‐up advances and discuss compatibility and complexity issues of current engineering approaches ...
Sergiy Gan   +2 more
wiley   +1 more source

A Comparison of Void-finding Algorithms Using Crossing Numbers

open access: yesThe Astrophysical Journal, 2023
We study how well void-finding algorithms identify cosmic void regions and whether we can quantitatively and qualitatively compare the voids they find with dynamical information from the underlying matter distribution.
Dahlia Veyrat   +2 more
doaj   +1 more source

Coherent band pathways between knots and links

open access: yes, 2014
We categorise coherent band (aka nullification) pathways between knots and 2-component links. Additionally, we characterise the minimal coherent band pathways (with intermediates) between any two knots or 2-component links with small crossing number.
Buck, Dorothy, Ishihara, Kai
core   +1 more source

Ergothioneine supplementation improves pup phenotype and survival in a murine model of spinal muscular atrophy

open access: yesFEBS Letters, EarlyView.
Spinal muscular atrophy (SMA) is a genetic disease affecting motor neurons. Individuals with SMA experience mitochondrial dysfunction and oxidative stress. The aim of the study was to investigate the effect of an antioxidant and neuroprotective substance, ergothioneine (ERGO), on an SMNΔ7 mouse model of SMA.
Francesca Cadile   +8 more
wiley   +1 more source

The warping degree of a link diagram [PDF]

open access: yes, 2009
For an oriented link diagram D, the warping degree d(D) is the smallest number of crossing changes which are needed to obtain a monotone diagram from D. We show that d(D)+d(-D)+sr(D) is less than or equal to the crossing number of D, where -D denotes the
Shimizu, Ayaka
core  

Approximating the rectilinear crossing number

open access: yesComputational Geometry, 2016
A straight-line drawing of a graph $G$ is a mapping which assigns to each vertex a point in the plane and to each edge a straight-line segment connecting the corresponding two points. The rectilinear crossing number of a graph $G$, $\overline{cr}(G)$, is the minimum number of crossing edges in any straight-line drawing of $G$. Determining or estimating
Fox, Jacob, Pach, János, Suk, Andrew
openaire   +5 more sources

Microbial exopolysaccharide production by polyextremophiles in the adaptation to multiple extremes

open access: yesFEBS Letters, EarlyView.
Polyextremophiles are microorganisms that endure multiple extreme conditions by various adaptation strategies that also include the production of exopolysaccharides (EPSs). This review provides an integrated perspective on EPS biosynthesis, function, and regulation in these organisms, emphasizing their critical role in survival and highlighting their ...
Tracey M Gloster, Ebru Toksoy Öner
wiley   +1 more source

Crossing number of Cartesian product of prism and path

open access: yesAKCE International Journal of Graphs and Combinatorics, 2020
An m-prism is the Cartesian product of an m-cycle and a path with 2 vertices. We prove that the crossing number of the join of an m-prism () and a graph with k isolated vertices is km for each We then use this result to prove that the crossing number of ...
Yip C. Yiew, Gek L. Chia, Poh-Hwa Ong
doaj   +1 more source

Mechanistic basis for inhibition of the extended‐spectrum β‐lactamase GES‐1 by enmetazobactam and tazobactam

open access: yesFEBS Letters, EarlyView.
Antimicrobial resistance (AMR) is of huge importance, resulting in over 1 million deaths each year. Here, we describe how a new drug, enmetazobactam, designed to help fight resistant bacterial diseases, inhibits a key enzyme (GES‐1) responsible for AMR. Our data show it is a more potent inhibitor than the related tazobactam, with high‐level computation
Michael Beer   +10 more
wiley   +1 more source

C9orf72 ALS‐causing mutations lead to mislocalization and aggregation of nucleoporin Nup107 into stress granules

open access: yesFEBS Letters, EarlyView.
Mutations in the C9orf72 gene represent the most common genetic cause of amyotrophic lateral sclerosis (ALS), a fatal neurodegenerative disease. Using patient‐derived neurons and C. elegans models, we find that the nucleoporin Nup107 is dysregulated in C9orf72‐associated ALS. Conversely, reducing Nup107 levels mitigates disease‐related changes.
Saygın Bilican   +7 more
wiley   +1 more source

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