Results 121 to 130 of about 1,312,414 (329)
Molecular Oncology, EarlyView.Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié +16 more
wiley +1 more source
Study of Drivers’ Behaviour at a Passive Railway Crossing
Promet (Zagreb), 2012 Problem: The number of killed and injured persons in incidents at railway level crossings is generally increasing on the Serbian Railways, particularly at passive crossings. In this paper we researched the direct behaviour of road traffic participants at
Sandra Kasalica +2 more
doaj +1 more source
Aggressive prostate cancer is associated with pericyte dysfunction
Molecular Oncology, EarlyView.Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero +11 more
wiley +1 more source
, 2009 Das Kreuzungszahlproblem wird von Graphentheoretikern seit über 60 Jahren betrachtet, jedoch ist noch immer sehr wenig über dieses einfache und zugleich hochkomplizierte Ma der Nichtplanarität bekannt. Die Aufgabenstellung ist simpel: Gegeben ein Graph, zeichnen Sie ihn mit der kleinstmöglichen Anzahl an Kantenkreuzungen.
openaire +2 more sources
Screening for lung cancer: A systematic review of overdiagnosis and its implications
Molecular Oncology, EarlyView.Low‐dose computed tomography (CT) screening for lung cancer may increase overdiagnosis compared to no screening, though the risk is likely low versus chest X‐ray. Our review of 8 trials (84 660 participants) shows added costs. Further research with strict adherence to modern nodule management strategies may help determine the extent to which ...
Fiorella Karina Fernández‐Sáenz +12 more
wiley +1 more source
Molecular Oncology, EarlyView.CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir +12 more
wiley +1 more source
Pedestrian crossing model in urban street (Case study on commercial area in Bandung)
MATEC Web of Conferences, 2018 Pedestrians who cross without any crossing facilities and under mixed-traffic tend to have varying responses. The responses can be analyzed by using multiple linear regression model, with pedestrian crossing delay and pedestrian crossing speed set as ...
Sulaksono Wibowo Sony, Wicaksana Rian
doaj +1 more source
Every 4-Connected Graph with Crossing Number 2 is Hamiltonian [PDF]
, 2018 Kenta Ozeki, Carol T. Zamfirescu
openalex +1 more source
Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA
Molecular Oncology, EarlyView.Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson +2 more
wiley +1 more source