Results 141 to 150 of about 308,302 (304)
The Largest Crossing Number of Tanglegrams
The Electronic Journal of CombinatoricsA tanglegram $\mathcal{T}$ consists of two rooted binary trees with the same number of leaves, and a perfect matching between the two leaf sets. In a layout, the tanglegrams is drawn with the leaves on two parallel lines, the trees on either side of the strip created by these lines are drawn as plane trees, and the perfect matching is drawn in straight
Éva Czabarka +2 more
openaire +2 more sources
Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma
Molecular Oncology, EarlyView.The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic +5 more
wiley +1 more source
CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3
Molecular Oncology, EarlyView.PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh +12 more
wiley +1 more source
Molecular Oncology, EarlyView.RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner +14 more
wiley +1 more source
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
On the Number of MUSs Crossing a Position
A string $w$ is said to be a minimal unique substring (MUS) of a string $T$ if $w$ occurs exactly once in $T$, and any proper substring of $w$ occurs at least twice in $T$. It is known that the number of MUSs in a string $T$ of length $n$ is at most $n$, and that the set $MUS(T)$ of all MUSs in $T$ can be computed in $O(n)$ time [Ilie and Smyth, 2011].
Hiroto Fujimaru +2 more
openaire +2 more sources
Molecular Oncology, EarlyView.A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel +12 more
wiley +1 more source
The stable crossing number of a twist family of knots and the satellite crossing number conjecture [PDF]
Twisting a given knot $K$ about an unknotted circle $c$ a full $n \in \mathbb{N}$ times, we obtain a "twist family" of knots $\{ K_n \}$. Work of Kouno-Motegi-Shibuya implies that for a non-trivial twist family the crossing numbers $\{c(K_n)\}$ of the ...
Baker, Kenneth L., Motegi, Kimihiko
core +1 more source
The Tripartite-Circle Crossing Number of Graphs With Two Small Partition Classes
Computing in Geometry and TopologyA tripartite-circle drawing of a tripartite graph is a drawing in the plane, where each part of a vertex partition is placed on one of three disjoint circles, and the edges do not cross the circles.
Charles Camacho +6 more
doaj +1 more source
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source