Results 131 to 140 of about 307,259 (304)

Individual wave overtopping volumes under crossing seas

open access: yes, 2019
The CROSSOVER project performed physical model tests in the large wave basin of Deltares on crossing seas and wave overtopping over a 1:3 smooth slope.
Prado Vieira Leite, Jorge
core   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

open access: yesMolecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary   +1 more
wiley   +1 more source

Maximum Rectilinear Crossing Number of Uniform Hypergraphs

open access: yes, 2023
We improve the lower bound on the $d$-dimensional rectilinear crossing number of the complete $d$-uniform hypergraph having $2d$ vertices to $\Omega\left(\dfrac{(4\sqrt{2}/3^{3/4})^d}{d}\right)$ from $\Omega(2^d \sqrt{d})$. We also establish that the $3$-
Gangopadhyay, Rahul, Ayan
core  

Clinical performance of the urine‐based TERT promoter AbsoluteQ Digital PCR for non‐invasive detection of bladder cancer

open access: yesMolecular Oncology, EarlyView.
A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel   +12 more
wiley   +1 more source

The Zero Divisor Graph of the Ring Zqp.

open access: yesScience Journal of University of Zakho, 2015
In this paper we construct a star zero divisor graph from the zero divisor graph of the ring Zqp. The star zero divisor graph is obtained by removing some vertices from the zero divisor graph Γ(Zqp), in different ways , but the best way to get star zero ...
Nazar H. Shuker, Payman A. Rashed
doaj  

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

open access: yesMolecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska   +13 more
wiley   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

open access: yesMolecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis   +3 more
wiley   +1 more source

Crossing number of graphs with rotation systems

open access: yes, 2007
We show that computing the crossing number of a graph with a given rotation system is NP-complete. This result leads to a new and much simpler proof of Hliněn´y’s result, that computing the crossing number of a cubic graph (without rotation system) is NP-
Daniel Stefankovič   +5 more
core   +1 more source

Longitudinal genome‐wide aneuploidy measurements in circulating cell‐free DNA to predict lack of benefit from pembrolizumab in patients with metastatic urothelial cancer

open access: yesMolecular Oncology, EarlyView.
Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi   +14 more
wiley   +1 more source

The Largest Crossing Number of Tanglegrams

open access: yesThe Electronic Journal of Combinatorics
A tanglegram $\mathcal{T}$ consists of two rooted binary trees with the same number of leaves, and a perfect matching between the two leaf sets. In a layout, the tanglegrams is drawn with the leaves on two parallel lines, the trees on either side of the strip created by these lines are drawn as plane trees, and the perfect matching is drawn in straight
Éva Czabarka   +2 more
openaire   +2 more sources

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