Results 91 to 100 of about 624,423 (312)

A novel Blind Start study design to investigate vestronidase alfa for mucopolysaccharidosis VII, an ultra-rare genetic disease.

Molecular Genetics and Metabolism, 2018
BACKGROUND Drug development for ultra-rare diseases is challenging because small sample sizes and heterogeneous study populations hamper the ability of randomized, placebo-controlled trials with a single primary endpoint to demonstrate valid treatment ...
P. Harmatz, C. Whitley, Raymond Y. Wang, M. Bauer, Wenjie Song, C. Haller, E. Kakkis   +6 more
semanticscholar   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Heritability and Genetic Variance Components in Sunflower Single Cross Hybrids [PDF]

Journal of Agricultural Science and Sustainable Production, 2015
In order to estimate genetic parameters in 16 Sunflower single cross hybrids obtained from crossing of 4 cytoplasmic male sterile and 4 fertility restorer lines, a North Carolina Design II was conducted using RCBD design with 3 replications at Khoy ...
AR Tarinejad, P Azizi, V Rashidi, M Ghaffari   +3 more
doaj  

Course Timetabling using Genetic Algorithm and Fuzzy Cross-Over

JOIV : International Journal on Informatics Visualization
Course timetabling at universities presents a complex problem due to the limited timeframe to create schedules that avoid conflicts between activities. This issue becomes more challenging as the number of activities increases while the available rooms remain constant. Numerous studies have attempted to automate the scheduling process, but their success
Febri Maspiyanti, Jullend Gatc, Sri Rezeki Candra Nursari, Amir Murtako   +3 more
openaire   +1 more source

Genetic Divergence Analysis over Seasons in Single Cross Hybrids of Maize (Zea mays L.)

, 2022
D2 analysis in single cross hybrids of maize over seasons indicated the influence of seasons on clustering patterns based on morpho-physiological and yield components. The cluster analysis assigned the 45 hybrids of maize single cross hybrids into five, six and seven major clusters in rabi, summer, and kharif, respectively based on the quantitative ...
N. Sabitha, D. Mohan Reddy, D. Lokanadha Reddy, M. Hemanth Kumar, P. Sudhakar, B. Ravindra Reddy, S. J. Mallikarjuna   +6 more
openaire   +1 more source

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

Natural crossing and isolation distance between cotton genotypes in turkey Cruzamento natural e distância de isolamento entre genótipos de algodão na turquia

Scientia Agricola, 2008
The purposes of this study were to determine the percentage of out-crossing, isolation distance and pollinator insect species for cotton (Gossypium hirsutum L.) seed production in the Aydin region in Turkey.
Taner Bozbek, Nedim Ozbek, Volkan Sezener, Oktay Erdogan, Ilkay Yavas, Aydin Unay   +5 more
doaj   +1 more source

Effects of Roads and Traffic on Wildlife Populations and Landscape Function Road Ecology is Moving toward Larger Scales [PDF]

, 2011
Road ecology has developed into a significant branch of ecology with steady growth in the number of refereed journal articles, books, conferences, symposia, and “best practice” guidelines being produced each year. The main objective of this special issue
Clevenger, A.P., Grift, E.A., van der, Jaeger, J.A.G., Ree, R., van   +3 more
core   +4 more sources

Paraneoplastic Lupus Nephritis in a Child With Neuroblastoma Recurrence

Pediatric Blood &Cancer, EarlyView.
Gabriele Mortari, Caterina Costagliola, Marta Nebiolo, Francesca Parisi, Martina Morini, Katia Mazzocco, Gabriele Gaggero, Stefano Volpi, Stefania Sorrentino, Virginia Livellara   +9 more
wiley   +1 more source

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source