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Considerations for crossover design in clinical study [PDF]
Korean Journal of Anesthesiology, 2021 This article introduces a crossover design that is often used in clinical studies, with the advantage of comparing treatment effects within one study subject. In particular, the advantages and disadvantages of the two-period, two-sequence crossover design (2 × 2 or AB/BA crossover design), which is widely used in clinical practice, are identified, and
Chi-Yeon Lim, Junyong In
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Study of universality crossover in the contact process [PDF]
Journal of Physics A: Mathematical and General, 2005 We consider a generalization of the contact process stochastic model, including an additional autocatalitic process. The phase diagram of this model in the proper two-parameter space displays a line of transitions between an active and an absorbing phase which starts at the critical point of the contact process and ends at the transition point of the ...
Jiirgen F. Stilck, Wellington G. Dantas
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A μSR study of the spin-crossover
Journal of Physics and Chemistry of Solids, 2004 The spin-crossover phenomenon is a cooperative low-spin to high-spin transition which can be initiated using temperature or light-irradiation. We have used muon-spin relaxation (μSR) to study this effect in Fe(PM-PEA)2(NCS)2 and Fe(PMAzA)2(NCS)2. We find Gaussian or exponential muon relaxation in the high-spin phase for the two compounds, reflecting ...
Blundell, S +4 more
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The use of baseline covariates in crossover studies [PDF]
Biostatistics, 2009 It is our experience that in many settings, crossover trials that have within-period baseline measurements are analyzed wrongly. A "conventional" analysis of covariance in this setting uses each baseline as a covariate for the following outcome variable in the same period but not for any other outcome.
James H. Roger, Michael G. Kenward
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A crossover study of short daily haemodialysis [PDF]
Nephrology Dialysis Transplantation, 2005 The benefits of daily haemodialysis (DHD) compared to conventional three times per week haemodialysis (CHD) have been described in a number of observational studies. Most of these previous studies however have not been performed with rigorous controls.We performed a crossover study following an A-B-A design: phase A was 4 weeks of thrice weekly ...
Natalia Nelson +5 more
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Extraction bradycardia: a pilot case-crossover study [PDF]
Head & Face Medicine, 2013 Abstract Purpose Significant vasovagal reaction is one of the untoward events in the course of simple extractions. The present study then aimed to record the patients’ heart rate during the extraction procedure. Materials and methods Informed consents were obtained in ...
Ashkan Rashad +3 more
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Crossover Studies of Pediatric Dental Sedation are Inappropriate [PDF]
Brazilian Dental Journal, 2019 Abstract Crossover studies continue to be published in spite of warnings about their inherent risks in relation to behavioral outcomes. This study took the opportunity of access to secondary data analysis in order to demonstrate the impact of a crossover design on the outcomes of randomized clinical trials aimed at the behavior of children during ...
Heloisa Sousa Gomes +4 more
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Computational approach to the study of thermal spin crossover phenomena [PDF]
The Journal of Chemical Physics, 2014 The key parameters associated to the thermally induced spin crossover process have been calculated for a series of Fe(II) complexes with mono-, bi-, and tridentate ligands. Combination of density functional theory calculations for the geometries and for normal vibrational modes, and highly correlated wave function methods for the energies, allows us to
Rudavskyi, Andrii +4 more
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Nonparametric Approaches to the Analysis of Crossover Studies
Statistical Science, 2004 We illustrate nonparametric, and particularly rank-based analyses of crossover studies, designs in which each subject receives more than one treatment over time. Principles involved in using the Wilcoxon rank sum test in the simple two-period, two-treatment crossover are described through theory and example.
Putt, Mary E., Chinchilli, Vernon M.
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A Crossover Comparative Study with Two Bulk Laxatives [PDF]
Journal of International Medical Research, 1983 Twenty elderly in-patients suffering from severe constipation were treated once daily for 2 weeks with each of two bulk laxatives. The preparations were allocated randomly as the first and second preparation. Agiolax, the new preparation, contained 15 mg senna glucosides, the old preparation, Lunelax comp., contained 25 mg senna glucoside A + B per ...
Mats Pers, Birgitta Pers
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