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Considerations for crossover design in clinical study [PDF]
This article introduces a crossover design that is often used in clinical studies, with the advantage of comparing treatment effects within one study subject. In particular, the advantages and disadvantages of the two-period, two-sequence crossover design (2 × 2 or AB/BA crossover design), which is widely used in clinical practice, are identified, and
Chi-Yeon Lim, Junyong In
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The coronavirus disease 2019 pandemic has led to the manufacturing of novel devices to protect clinicians from the risk of transmission, including the aerosol box for use during tracheal intubation.
J. Begley+3 more
semanticscholar +1 more source
Background Wildfire events are increasing in prevalence in the western United States. Research has found mixed results on the degree to which exposure to wildfire smoke is associated with an increased risk of mortality.
A. Doubleday+6 more
semanticscholar +1 more source
Aims It is unclear whether night-time noise events, including from aeroplanes, could trigger a cardiovascular death. In this study, we investigate the potential acute effects of aircraft noise on mortality and the specific role of different night-time ...
A. Saucy+5 more
semanticscholar +1 more source
Study of universality crossover in the contact process [PDF]
We consider a generalization of the contact process stochastic model, including an additional autocatalitic process. The phase diagram of this model in the proper two-parameter space displays a line of transitions between an active and an absorbing phase which starts at the critical point of the contact process and ends at the transition point of the ...
Jiirgen F. Stilck, Wellington G. Dantas
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A μSR study of the spin-crossover
The spin-crossover phenomenon is a cooperative low-spin to high-spin transition which can be initiated using temperature or light-irradiation. We have used muon-spin relaxation (μSR) to study this effect in Fe(PM-PEA)2(NCS)2 and Fe(PMAzA)2(NCS)2. We find Gaussian or exponential muon relaxation in the high-spin phase for the two compounds, reflecting ...
Blundell, S+4 more
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The use of baseline covariates in crossover studies [PDF]
It is our experience that in many settings, crossover trials that have within-period baseline measurements are analyzed wrongly. A "conventional" analysis of covariance in this setting uses each baseline as a covariate for the following outcome variable in the same period but not for any other outcome.
James H. Roger, Michael G. Kenward
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Biophilia hypothesis suggests humans have an innate connection to nature which may affect our health and productivity. Yet we currently live in a world that is rapidly urbanizing with people spending most of their time indoors.
Jie Yin+5 more
semanticscholar +1 more source
A crossover study of short daily haemodialysis [PDF]
The benefits of daily haemodialysis (DHD) compared to conventional three times per week haemodialysis (CHD) have been described in a number of observational studies. Most of these previous studies however have not been performed with rigorous controls.We performed a crossover study following an A-B-A design: phase A was 4 weeks of thrice weekly ...
Natalia Nelson+5 more
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BACKGROUND Sodium glucose cotransporter-2 (SGLT2) inhibitors are the most recently approved class of drugs for type 2 diabetes and provide both glycemic efficacy and cardiovascular risk reduction. A number of safety issues have been identified, including
J. Blau+10 more
semanticscholar +1 more source