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Considerations for crossover design in clinical study [PDF]

open access: yesKorean Journal of Anesthesiology, 2021
This article introduces a crossover design that is often used in clinical studies, with the advantage of comparing treatment effects within one study subject. In particular, the advantages and disadvantages of the two-period, two-sequence crossover design (2 × 2 or AB/BA crossover design), which is widely used in clinical practice, are identified, and
Chi-Yeon Lim, Junyong In
openaire   +5 more sources

The aerosol box for intubation in coronavirus disease 2019 patients: an in‐situ simulation crossover study

open access: yesAnaesthesia, 2020
The coronavirus disease 2019 pandemic has led to the manufacturing of novel devices to protect clinicians from the risk of transmission, including the aerosol box for use during tracheal intubation.
J. Begley   +3 more
semanticscholar   +1 more source

Mortality associated with wildfire smoke exposure in Washington state, 2006–2017: a case-crossover study

open access: yesEnvironmental Health, 2020
Background Wildfire events are increasing in prevalence in the western United States. Research has found mixed results on the degree to which exposure to wildfire smoke is associated with an increased risk of mortality.
A. Doubleday   +6 more
semanticscholar   +1 more source

Does night-time aircraft noise trigger mortality? A case-crossover study on 24 886 cardiovascular deaths

open access: yesEuropean Heart Journal, 2020
Aims It is unclear whether night-time noise events, including from aeroplanes, could trigger a cardiovascular death. In this study, we investigate the potential acute effects of aircraft noise on mortality and the specific role of different night-time ...
A. Saucy   +5 more
semanticscholar   +1 more source

Study of universality crossover in the contact process [PDF]

open access: yesJournal of Physics A: Mathematical and General, 2005
We consider a generalization of the contact process stochastic model, including an additional autocatalitic process. The phase diagram of this model in the proper two-parameter space displays a line of transitions between an active and an absorbing phase which starts at the critical point of the contact process and ends at the transition point of the ...
Jiirgen F. Stilck, Wellington G. Dantas
openaire   +4 more sources

A μSR study of the spin-crossover

open access: yesJournal of Physics and Chemistry of Solids, 2004
The spin-crossover phenomenon is a cooperative low-spin to high-spin transition which can be initiated using temperature or light-irradiation. We have used muon-spin relaxation (μSR) to study this effect in Fe(PM-PEA)2(NCS)2 and Fe(PMAzA)2(NCS)2. We find Gaussian or exponential muon relaxation in the high-spin phase for the two compounds, reflecting ...
Blundell, S   +4 more
openaire   +5 more sources

The use of baseline covariates in crossover studies [PDF]

open access: yesBiostatistics, 2009
It is our experience that in many settings, crossover trials that have within-period baseline measurements are analyzed wrongly. A "conventional" analysis of covariance in this setting uses each baseline as a covariate for the following outcome variable in the same period but not for any other outcome.
James H. Roger, Michael G. Kenward
openaire   +3 more sources

Effects of Biophilic Interventions in Office on Stress Reaction and Cognitive Function: A Randomized Crossover Study in Virtual Reality.

open access: yesIndoor Air: International Journal of Indoor Environment and Health, 2019
Biophilia hypothesis suggests humans have an innate connection to nature which may affect our health and productivity. Yet we currently live in a world that is rapidly urbanizing with people spending most of their time indoors.
Jie Yin   +5 more
semanticscholar   +1 more source

A crossover study of short daily haemodialysis [PDF]

open access: yesNephrology Dialysis Transplantation, 2005
The benefits of daily haemodialysis (DHD) compared to conventional three times per week haemodialysis (CHD) have been described in a number of observational studies. Most of these previous studies however have not been performed with rigorous controls.We performed a crossover study following an A-B-A design: phase A was 4 weeks of thrice weekly ...
Natalia Nelson   +5 more
openaire   +3 more sources

Canagliflozin triggers the FGF23/1,25-dihydroxyvitamin D/PTH axis in healthy volunteers in a randomized crossover study.

open access: yesJCI Insight, 2018
BACKGROUND Sodium glucose cotransporter-2 (SGLT2) inhibitors are the most recently approved class of drugs for type 2 diabetes and provide both glycemic efficacy and cardiovascular risk reduction. A number of safety issues have been identified, including
J. Blau   +10 more
semanticscholar   +1 more source

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