Results 31 to 40 of about 24,917,350 (235)

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

On Crowd Density Estimation for Surveillance

, 2006
The goal of this work is to use computer vision to measure crowd density in outdoor scenes. Crowd density estimation is an important task in crowd monitoring. The assessment is carried out using images of a graduation scene which illustrated variation of
Rahmalan, Hidayah, M.S. Nixon, H. Rahmalan, Nixon, Mark S., Carter, John N., J.N. Carter   +5 more
core   +2 more sources

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Control of collective human behavior: Social dynamics beyond modeling

Physical Review Research, 2022
The motion of pedestrians is a paradigmatic phenomenon to study collective human behavior. We propose a model-free approach to analyze the movement of pedestrians in experiments and get a quantitative understanding of crowd dynamics.
Ilias Panagiotopoulos, Jens Starke, Wolfram Just   +2 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

FEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya, Masatake Osawa, Hidefumi Fukumitsu   +2 more
wiley   +1 more source

Bridging Crowd Analysis and Natural Language: A New Vision Language Approach for Behavioral Video Captioning

IEEE Access
Crowd analysis is a critical application area for addressing challenges in domains such as transportation and public safety within smart cities.
Selen Gurbuz, Turan Goktug Altundogan, Mehmet Karakose   +2 more
doaj   +1 more source

Exploring the Consequences of Crowd Compression Through Physics-Based Simulation

Sensors, 2018
Statistical analysis of accidents in recent years shows that crowd crushes have become significant non-combat, non-environmental public disasters. Unlike common accidents such as fires, crowd crushes may occur without obvious external causes, and may ...
Libo Sun, Norman I. Badler
doaj   +1 more source

Toward multi-granularity spatiotemporal simulation modeling of crowd movement for dynamic assessment of tourist carrying capacity

GIScience & Remote Sensing, 2022
Dynamic process simulation and prediction of crowd movement are effective approaches to understanding the complex human behavior system in GIScience. At present, obtaining full-sample individual trajectory data still faces challenges because of privacy ...
Nuozhou Shen, Haiping Zhang, Haoran Wang, Xuanhong Zhou, Lei Zhou, Guo’An Tang   +5 more
doaj   +1 more source

Resistance to change and frequency of response-dependent stimuli uncorrelated with reinforcement.

, 2009
Stimuli uncorrelated with reinforcement have been shown to enhance response rates and resistance to disruption; however, the effects of different rates of stimulus presentations have not been assessed.
Shahan, Timothy A., Podlesnik, Christopher A., Ward, Ryan D., Jimenez-Gomez, Corina, Ward, RD, Shahan, TA, Podlesnik, Christopher, Jimenez-Gomez, C   +7 more
core   +1 more source