Results 91 to 100 of about 609,876 (337)
This study identifies ferritin as a pivotal mediator of silica‐induced pulmonary fibrosis. Macrophage‐derived ferritin drives fibroblast‐to‐myofibroblast differentiation via the PIK3R2/SMAD pathway, while ferritin knockdown alleviates fibrosis. These findings define ferritin as both a biomarker and pathogenic driver, highlighting ferritin‐PIK3R2 ...
Liqun Wang +14 more
wiley +1 more source
Integrative Approaches to Treating Cellular Senescence in Kidney Disease
ABSTRACT Cellular senescence in the kidney plays a crucial role in the progression of acute kidney injury and chronic kidney disease. Therapeutic approaches targeting senescent cells, such as small molecule senolytic and senomorphic drugs, display efficacy in preclinical models.
Tomoka Misawa +3 more
wiley +1 more source
Editorial: von Willebrand factor and CRP levels may predict survival in liver cirrhosis [PDF]
Manuela Merli, V. Di Gregorio
openalex +1 more source
Systematically Engineering for Efficient Production of 3‐Methyl‐1‐Butanol in Escherichia coli
An integrated metabolic engineering strategy was established for high‐level 3‐methyl‐1‐butanol biosynthesis in Escherichia coli. Molecular dynamics‐guided semi‐rational engineering of dihydroxyacid dehydratase uncovered and relieved key catalytic bottlenecks, while adaptive laboratory evolution enhanced strain robustness.
Nanfei Geng +6 more
wiley +1 more source
Fórum nacional em defesa da escola pública na LDB: a questão da docência
Esse trabalho tem como perspectiva colocar em análise o modo pelo qual os movimentos sociais vêm abordando as questões da saúde do trabalhador docente em suas lutas, não apenas como ausência de doença, mas como um estado em que a saúde rompe com os ...
Fabiana Castelo Valadares +1 more
doaj
The necrotrophic white mold fungus Sclerotinia sclerotiorum (S. sclerotiorum) is pathogenic to a broad range of plant species, including the Brassicaceae model plant Arabidopsis thaliana (Boland and Hall, 1994; Bolton et al., 2006).
Malou Fraiture, Frédéric Brunner
doaj +1 more source

