Results 171 to 180 of about 68,000 (256)

Automated Bacterial Identification and Morphological Feature Analysis in Low‐Dose Cryo‐EM Using YOLOv11

Advanced Intelligent Discovery, EarlyView.
AI‐based tools enable rapid characterization of bacterial ultrastructure in low‐dose cryogenic transmission electron microscopy. The envelope thickness tool quantifies membrane thickness and anisotropy. The flagella module analyzes filament morphology and detects cell‐flagella contacts.
Sita Sirisha Madugula, Lynnicia N. Massenburg, Spenser R. Brown, Amber N. Bible, Chanda R. Harris, Lance X. Zhang, Kiara Parker, Scott T. Retterer, Jennifer L. Morrell‐Falvey, Rama K. Vasudevan, Alexis N. Williams   +10 more
wiley   +1 more source

Inhibition and Formation of Amyloid Fibrils in the Bulk and at the Interface of Biomolecular Condensates

Angewandte Chemie, EarlyView.
In this review, we discuss how biomolecular condensates can inhibit amyloid aggregation in their interior, while still facilitating fibril formation at the interface between the dense and dilute phases, where molecular and mesoscale properties are likely optimal to promote protein aggregation.
Marcell Papp, Chiara Morelli, Sarah Khawaja, Paolo Arosio   +3 more
wiley   +2 more sources

Mechanism of beta-arrestin 1 mediated Src activation via Src SH3 domain revealed by cryo-electron microscopy. [PDF]

Nat Commun
Pakharukova N, Thomas BN, Bansia H, Li L, Bassford DK, Abzalimov RR, Kim J, Kahsai AW, Pani B, Xiao K, Ochakovski R, Liu S, Zhang X, Ahn S, des Georges A, Lefkowitz RJ.   +15 more
europepmc   +1 more source

Liposomal Delivery of L‐2‐Hydroxyglutarate for Targeting Epigenetic Dysregulation in Osteoarthritis

Advanced NanoBiomed Research, EarlyView.
Osteoarthritis involves cartilage degeneration, inflammation, and epigenetic dysregulation. A liposomal formulation of the TET1 inhibitor L‐2‐hydroxyglutarate to overcome rapid joint clearance was developed. The formulation showed good physicochemical properties, reduced inflammatory and catabolic gene expression in chondrocytes, and alleviated ...
Denise Murgia, Akshay Pandey, Raffaele Spanò, Bianca Martins Estevão, Roberto Palomba, Greta Avancini, Tamaghna Gupta, Ana Maria Lopez Estevez, Stuart B. Goodman, Nidhi Bhutani, Paolo Decuzzi   +10 more
wiley   +1 more source

Virus‐Mediated Self‐Assembly of Functional Cyclodextrins for Antiviral Inhibition

Angewandte Chemie, EarlyView.
A sialic acid (SA)‐functionalized cyclodextrin (CD) self‐assembles on SARS‐CoV‐2 through ligand–receptor recognition, nucleating cooperative supramolecular polymer growth that blocks infection. The adaptive assembly requires both ligand binding and host–guest polymerization, remains active across variants, and can be tuned by coassembly, establishing ...
Pedro J. Hernando, Laora Boulo, Léonid Lavnevich, Elisa Teyssou, Stéphane Marot, Adélie Gothland, Jean‐Michel Guigner, Anne‐Geneviève Marcelin, Mickaël Ménand, Vincent Calvez, Matthieu Sollogoub   +10 more
wiley   +2 more sources

In situ cryo-electron microscopy and tomography of cellular and organismal samples. [PDF]

Curr Opin Struct Biol
Majumder P, Zhang P.
europepmc   +1 more source

Structural basis for T-cell intracellular antigen-1 amyloid fibril formation revealed by cryo-electron microscopy. [PDF]

PNAS Nexus
Inaoka D, Miyata T, Makino F, Ohtani Y, Ekari M, Kobayashi R, Imamura K, Sakamoto E, Kodama TS, Yoshida N, Kato T, Namba K, Tochio H, Sekiyama N.   +13 more
europepmc   +1 more source

A Lipid‐Conjugation Strategy for Intracellular Reactive Oxygen Species Control in Hepatic Cells

Angewandte Chemie, EarlyView.
A lipid conjugation strategy anchors a manganese Salen complex within phospholipid membranes, yielding stable, catalytically active liposomes. These lipid–metal assemblies efficiently degrade reactive oxygen species (ROS) and enable intracellular redox control in steatotic HepaRG cells, offering a precise route to biomimetic antioxidant design ...
Olav Vestrheim, Huichao Zhao, Anders Bodholt Nielsen, Nino Wili, Niels Chr. Nielsen, Joseph A. Lyons, Rajeshwar Prosad Mookerjee, Brigitte Städler   +7 more
wiley   +2 more sources

Dose-efficient cryo-electron microscopy for thick samples using tilt- corrected scanning transmission electron microscopy. [PDF]

Nat Methods
Yu Y, Spoth KA, Colletta M, Nguyen KX, Zeltmann SE, Zhang XS, Paraan M, Kopylov M, Dubbeldam C, Serwas D, Siems H, Muller DA, Kourkoutis LF.   +12 more
europepmc   +1 more source

Spatially Coupled Cl2 Confinement and Activation at Curved Ni Single‐Atom Sites for Highly Reversible Li–Cl2 Batteries

Angewandte Chemie, EarlyView.
A robust cathode featuring curvature‐engineered Ni single‐atoms anchored within hierarchical pores effectively confines Cl2 and accelerates Cl0/Cl−1 redox kinetics. This synergistic architecture unlocks the potential of Li‐Cl2 secondary batteries with an unprecedented 1×106 mAh g−1 cumulative capacity, all‐climate resilience (–40°C to + 70°C), and 7.65
Minggang Xie, Keren Jiang, Xuehai Tan, Xuesong Xie, Zheng Cheng, Xianbin Meng, Yuxuan Xue, Yi Guan, Zhixuan Chen, Yifan Li, Renfei Feng, Zhi Li   +11 more
wiley   +2 more sources