Results 171 to 180 of about 2,310,044 (293)

Flame Suppression in Lithium‐Ion Batteries During Thermal Runaway Through Solvent Design Considering the Volatility–Flammability Relationship

Advanced Science, EarlyView.
An asymmetric sulfonate solvent forms thermally stable interphases and demonstrates non‐flammability, suppressing heat accumulation for safer, high‐performance lithium‐ion batteries. ABSTRACT An asymmetric sulfonate‐based linear solvent, 2,2,2‐trifluoromethyl mesylate (FMS), is designed and used as the primary solvent in liquid electrolytes to enhance ...
Chi‐Yeong Hong, Joon Ha Chang, Ho Yeon Jang, Jooeun Byun, Chae Rim Lee, Jeongmin Kim, Oh B. Chae, Youngjin Kim, Jun Ho Song, Chihyun Hwang, Seoin Back, Ki Jae Kim, Hyun‐seung Kim   +12 more
wiley   +1 more source

Counting particles in cryo-electron microscopy may result in incorrect population estimates. [PDF]

Commun Biol
Evans L, Dingeldein L, Covino R, Gilles MA, Thiede E, Cossio P.   +5 more
europepmc   +1 more source

Phase Separation, Material State, and Condensate Fate in Mammalian Autophagy

Advanced Science, EarlyView.
ABSTRACT Biomolecular phase separation has emerged as a key organizing principle in macroautophagy (hereafter autophagy). In mammalian cells, phase‐separated condensates not only serve as substrates for selective degradation, but also act as dynamic platforms for cargo recognition, signaling integration, and autophagosome assembly.
Yuanqiang Lin, Mingran Dai, Enyong Dai, Rui Kang, Daniel J. Klionsky, Daolin Tang, Yu Sun, Ningning Lv, Junnan Jiang   +8 more
wiley   +1 more source

Convergence of cryo-electron microscopy and artificial intelligence in integrative structural biology: A critical review of advances, synergies, and implications for molecular biophysics and drug discovery. [PDF]

J Microsc
Abinawanto, Sophian A.
europepmc   +1 more source

An Engineered HR1‐Stem Helix‐HR2 Trimeric Platform for Developing Broad‐Spectrum Coronavirus Vaccines

Advanced Science, EarlyView.
Sun et al. report a self‐assembling trimeric subunit vaccine platform termed RHS, which integrates the JN.1 receptor‐binding domain (RBD) with the heptad repeat 1 (HR1), stem helix (SH), and heptad repeat 2 (HR2) regions. The SARS‐CoV‐2 RHS vaccine elicits variant‐reactive RBD‐specific antibodies and cross‐reactive SH‐specific antibodies against ...
Xikui Sun, Junhao Fan, Xiaolu Xie, Yuting Shi, Xiaoqing Liu, Tiefeng Xu, Sidi Yang, Keda Shi, Chengshu Xie, Shixiong Li, Siwen Chen, Ruoxi Cai, Ping He, Yuzhen Ye, Tao Chen, Xiancai Ma, Chunmei Li, Jingyou Yu, Deyin Guo   +18 more
wiley   +1 more source

The evolving role of structural biology in pharma: integration of X-ray crystallography, cryo-electron microscopy and beyond. [PDF]

Acta Crystallogr D Struct Biol
Chrencik JE, Su HP, Gomez Llorente Y, Palte RL, Klein DJ, Hayes RP, Antine SP, Asmar-Rovira GA, Bertoletti N, Byrne NJ, Carroll BL, Cordeiro CD, Curfman K, Dutko J, Eddins MJ, Fischmann T, Govindarajan B, Hecksel CW, Ho T, Hollenstein K, Hong MR, Hruza A, Ishchenko A, Jaime-Garza M, Jaremko MJ, Knox HL, Kostas J, Krishnamurthy H, Manolaridis I, Noland CL, Partridge AT, Patel SB, Reichert P, Reid JC, Felisberto-Rodrigues C, Shintre CA, Shipman JM, Tamilselvan E, Walker ME, Walker SN, Wang R, Wright KM, Yen TJ, Yoo BK, Gabelli SB.   +44 more
europepmc   +1 more source

Structural Basis of Shiga Toxin Neutralization by Human Antibodies Targeting Canonical Receptor‐Binding and Non‐Canonical Assembly Sites

Advanced Science, EarlyView.
Cryo‐electron microscopy structures reveal two distinct neutralization mechanisms of fully human monoclonal antibodies targeting the Shiga toxin 1a B subunit. RDS059 occludes the Gb3 receptor‐binding site, whereas RDS045 engages a lateral quaternary epitope to disrupt holotoxin assembly.
Jianting Ke, Xin Li, Xiaoli Wang, Zhaoxia Huang, Shaojie Xue, Yuyang Liu, Jing Pan, Guowei Hu, Yayu Wang, Cheng Wang, Shoudeng Chen   +10 more
wiley   +1 more source

Reply to: About proteins of a siphophage tail tip complex reverting to their pre-ejection fold after DNA ejection

Nature Communications
Rafael Ayala, Andrey V. Moiseenko, Ting-Hua Chen, Eugene E. Kulikov, Alla K. Golomidova, Philipp S. Orekhov, Maya A. Street, Olga S. Sokolova, Andrey V. Letarov, Matthias Wolf   +9 more
doaj   +1 more source

Bridging the Structural Gap: A Methodological Review of Cryo-Electron Microscopy for Underrepresented Viruses. [PDF]

Viruses
Park YH, Jung HS, Moon S, Song C.
europepmc   +1 more source

Machine‐Learning‐Assisted Impedance Component Analysis Enables Standardizable Surface Protein Analysis of Extracellular Vesicles Using Engineered Nanovesicles

Advanced Science, EarlyView.
This study establishes a universally applicable framework for vesicle surface analysis by combining engineered amyloid‐β‐displaying nanovesicles with machine‐learning‐optimized impedance spectroscopy. Equivalent‐circuit modeling reveals that membrane capacitance correlates with the surface protein states, enabling label‐free quantification of vesicle ...
Jaeyoon Song, Neethu Ramakrishnan, Sehyeon Kim, Huiseop Lee, Youngeun Kwon, Jinsik Kim   +5 more
wiley   +1 more source