Results 191 to 200 of about 133,701 (285)

Injectable Hydrogel with Rapid Coagulation, Low Swelling, and High Burst Pressure Tolerance Properties for Long‐Term Management of Bleeding Wound

Advanced Science, EarlyView.
An injectable PACmC hydrogel with “rigid island‐flexible chain” architecture is developed, featuring low swelling (49.2% within 7 d), strong wet adhesion (46.5 kPa), and high burst pressure (701 mm Hg), which can achieve rapid hemostasis and long‐term sealing in rabbit and porcine models of hepatic and splenic hemorrhage.
Yang Ouyang, Wenfeng Qiu, Weiwen Liang, Xin Zhang, Weijie Liu, Zixin Chen, Yifei Li, Hui Wang, Youchen Tang, Min Li, Rongkang Huang, Zijian Chen, Binghua Ma   +12 more
wiley   +1 more source

Purification of the Active-State G Protein-Coupled Receptor ADGRL4 for Cryo-Electron Microscopy Using a Modular Tag System and a Tethered mini-G_q. [PDF]

Bio Protoc
Favara DM, Tate CG.
europepmc   +1 more source

Discovery of a Potent Fluorescence Polarization Probe for Identifying USP1 Allosteric Inhibitors

Advanced Science, EarlyView.
This study presents the first ubiquitin‐specific protease 1 (USP1) allosteric fluoroprobe and fluorescence polarization assay, enabling the differentiation of allosteric and catalytic site inhibitors. Further, a novel class of tetrahydroisoquinoline‐based USP1 inhibitors is designed, with compound 14a (USP1 IC50 = 29.9 nM) showing strong selectivity ...
Jiawei Cheng, Peipei Wang, Pengfei Wang, Jiamin Wang, Baiyang Li, Daqing Fang, Jian He, Xiaobei Hu, Weijuan Kan, Yubo Zhou, Chunpu Li, Jia Li, Hong Liu   +12 more
wiley   +1 more source

Dose-efficient cryo-electron microscopy for thick samples using tilt- corrected scanning transmission electron microscopy. [PDF]

Nat Methods
Yu Y, Spoth KA, Colletta M, Nguyen KX, Zeltmann SE, Zhang XS, Paraan M, Kopylov M, Dubbeldam C, Serwas D, Siems H, Muller DA, Kourkoutis LF.   +12 more
europepmc   +1 more source

Precipitation‐Modulated Harmonic Architectures Enable Superior Strength–Ductility Synergy from Cryogenic to Elevated Temperatures in Nanostructured Alloys

Advanced Science, EarlyView.
Precipitation‐modulated recrystallization enables a programmable bimodal harmonic architecture in a high‐entropy alloy, delivering 1–2 GPa yield strength with >10% ductility from −196 °C to 700 °C. The resulting broad‐temperature robustness arises from the synergy of dual‐mode nanoprecipitation, harmonic core–shell topology, and temperature‐adaptive ...
Wei Li, Liangyin Xiong, Mengchao Niu, Junhua Luan, Wei Wang, Zengbao Jiao   +5 more
wiley   +1 more source

Constitutively active orphan G protein-coupled receptors through the lenses of cryo-electron microscopy. [PDF]

J Biol Chem
Argerich J, Muñoz-Reyes D, Val-García ID, García-Nafría J.   +3 more
europepmc   +1 more source

Scalable Engineering of Bio‐Manufactured Extracellular Vesicles for Selective Delivery in Ovarian Cancer Patient‐Derived Models

Advanced Science, EarlyView.
Engineered extracellular vesicles displaying Ephrin‐B2 selectively target Ephrin‐B4–expressing ovarian cancer cells, enabling precise delivery in patient‐derived models. This scalable bio‐manufacturing platform reveals a versatile strategy to exploit Ephrin signaling for highly specific therapeutic payload delivery and motivates exploration of tailored
Nihar Godbole, Andrew Lai, Alexander Quinn, Marianne Gillard, Dominic Guanzon, Katherin Scholz‐Romero, Alexis Salas‐Burgos, Bastián Lillo Dapremont, Rohan Lourie, Naven Chetty, Richard Lobb, Kate Beecher, Amy E. McCart Reed, Kaltin Ferguson, Biao Sun, Yaowu He, John D. Hooper, Carlos Salomon   +17 more
wiley   +1 more source

Resolving Oxidative and Corrosive Calendar‐Aging via Electrolyte Engineering for Stable Lithium Metal Batteries

Advanced Energy Materials, EarlyView.
A weakly solvating ether solvent, 1,2‐dimethoxypropane (DMP), is proposed for use in localized high‐concentration electrolytes (LHCEs) for lithium metal batteries (LMBs). These DMP‐based LHCEs simultaneously suppress lithium metal corrosion and cathode degradation—two interrelated processes that accelerate calendar aging of LMBs.
Jisub Kim, Ihnkyung Jung, Kyunam Lee, Insu Hwang, Minkwan Kim, Eunseok Park, Dongmin Park, Hayoung Park, Yonggoon Jeon, Gaeun Park, Hyo Chul Ahn, Jihoon Oh, Jungwon Park, Ali Coskun, Jang Wook Choi   +14 more
wiley   +1 more source

Native state structural and chemical characterisation of Pickering emulsions: A cryo-electron microscopy study. [PDF]

J Microsc
Fernandez Ainaga DL, Roncal-Herrero T, Ilett M, Aslam Z, Cheng C, Hitchcock JP, Cayre OJ, Hondow N.   +7 more
europepmc   +1 more source

Sulfide‐Based Electrolytes for All‐Solid‐State Sodium Batteries

Advanced Energy Materials, EarlyView.
This review covers the structural features and synthesis strategies of sulfide‐based solid electrolytes, as well as critical challenges related to conductivity, interfacial and moisture stability, and scaling‐up for practical application in Sodium‐based All Solid‐State Batteries.
Han Yang, Luca Weckelmann, Baolin Wu, Chih‐Long Tsai, Luc Raijmakers, Rüdiger‐A. Eichel, Anna Windmüller   +6 more
wiley   +1 more source