Results 211 to 220 of about 6,053 (258)

Reprogramming tumor immune microenvironment by ultrasound‐responsive nanoplatforms for enhanced cancer immunotherapy

BMEMat, EarlyView.
Ultrasound‐responsive nanoplatforms reprogram the tumor immune microenvironment by targeting tumor cells, immune cells, and non‐immune stromal cells to enhance the efficacy of cancer immunotherapy. Abstract Cancer immunotherapy represents a significant advancement in cancer treatment by enhancing the specific recognition and elimination of cancer cells.
Shilong Zhao, Rui Qu, Zan Dai, Xiqun Jiang, Xu Zhen   +4 more
wiley   +1 more source

Harnessing ferroptosis from multilayer defense networks to nanoplatforms for specific cancer therapy

BMEMat, EarlyView.
Nanomaterials target metabolically‐regulated ferroptosis for cancer therapy. Iron‐based or alternative nanoplatforms integrate ferroptosis with chemotherapy, immunotherapy, or radiotherapy. They enable stimulus‐responsive therapies (photothermal, photodynamic, sonodynamic) activated by near‐infrared, light, or ultrasound, achieving potent synergistic ...
Xinyue Xu, Xuejian Wang, Wenyan Jiang, Wan Hairul Anuar Kamaruddin, Chunyan Fang, Pengfei Zhang   +5 more
wiley   +1 more source

Transfersomes with core and surface‐loaded NF‐κB p65 siRNA for enhanced transdermal transfection and effective treatment of psoriasis

BMEMat, EarlyView.
TCPL, a transfersome with Tween 80 and PEI, enables efficient transdermal siNF‐κB delivery, resolving PEI's toxicity issue. It promotes lysosomal escape and effective transfection, silences NF‐κB, modulates immunity, and inhibits angiogenesis, alleviating psoriasis. With good biocompatibility, TCPL holds strong clinical translation potential. Schematic
Hui Xing, Yuhui Yang, Ziyi Zhao, Kai Lv, Yiran Shao, Zhi Zhang, Dong Ma   +6 more
wiley   +1 more source

Three-Dimensional Structure of Cytochrome c Nitrite Reductase As Determined by Cryo-Electron Microscopy

, 2018
Baymukhametov, T. N., Chesnokov, Y. M., Pichkur, E. B., Boyko, K. M., Tikhonova, T. V., Alexander G. Myasnikov, Vasiliev, A. L., Lipkin, A. V., Popov, V. O., Kovalchuk, M. V.   +9 more
openalex   +1 more source

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Cryo-Electron Microscopy of Biological Samples

Ultrastructural Pathology, 2006
A brief summary of current cryo-electron microscopy methods for processing and imaging biological tissues is provided. The main emphasis is given to two preparation procedures: frozen-hydrated samples because of the remarkable success of cryo-electron crystallography in obtaining near atomic resolution of integral membrane proteins, and high-pressure ...
M Joseph Costello
exaly   +3 more sources

Automated cryo-electron microscopy

Proceedings IEEE International Symposium on Biomedical Imaging, 2003
Cryo-electron microscopy is widely viewed as a uniquely powerful method for the study of membrane proteins and large macromolecular complexes - subjects that are viewed as extremely challenging or impossible to study using x-ray or NMR methods. Although the methodology of molecular microscopy has enormous potential, it is time consuming and labor ...
Clinton S. Potter, D. Fellmann, Ron A. Milligan, Jim Pulokas, Christian Suloway, Yuanxin Zhu, A. Carragher   +6 more
openaire   +1 more source

Cryo electron microscopy

Ultramicroscopy, 1982
Abstract A brief review of significant attempts to overcome the problem of radiation damage is given, which indicates cryo electron microscopy as a likely solution. The need for clear understanding of the physical mechanism of cryo electron microscopy is stressed, and possible means to achieve such an understanding is indicated.
openaire   +2 more sources

Cryo-electron Microscopy of Protein Cages

2023
Protein cages are one of the most widely studied objects in the field of cryogenic electron microscopy-encompassing natural and synthetic constructs, from enzymes assisting protein folding such as chaperonin to virus capsids. Tremendous diversity of morphology and function is demonstrated by the structure and role of proteins, some of which are nearly ...
Raymond N, Burton-Smith, Kazuyoshi, Murata   +1 more
openaire   +2 more sources

Cryo‐electron microscopy and cryo‐electron tomography of nanoparticles

WIREs Nanomedicine and Nanobiotechnology, 2016
Cryo‐transmission electron microscopy (cryo‐TEM or cryo‐EM) and cryo‐electron tomography (cryo‐ET) offer robust and powerful ways to visualize nanoparticles. These techniques involve imaging of the sample in a frozen‐hydrated state, allowing visualization of nanoparticles essentially as they exist in solution. Cryo‐TEM grid preparation can be performed
openaire   +2 more sources

Cryo-electron Microscopy of the Giant Mimivirus

Journal of Molecular Biology, 2005
Mimivirus is the largest known virus. Using cryo-electron microscopy, the virus was shown to be icosahedral, covered by long fibers, and appears to have at least two lipid membranes within its protein capsid. A unique vertex, presumably for attachment and infection of the host, can be seen for particles that have a suitable orientation on the ...
Chuan, Xiao, Paul R, Chipman, Anthony J, Battisti, Valorie D, Bowman, Patricia, Renesto, Didier, Raoult, Michael G, Rossmann   +6 more
openaire   +2 more sources