Results 231 to 240 of about 2,439,094 (286)

Extracellular Vesicles‐Based Biological Macromolecule Delivery Systems: Biogenesis, Characterization, and Emerging Clinical Applications

Biotechnology and Bioengineering, EarlyView.
ABSTRACT Extracellular vesicles (EVs) are nanoscale membrane‐bound structures that play a pivotal role in intercellular communication by transporting bioactive molecules, including proteins, lipids, nucleic acids, and organelles, between cells. Originating from the endosomal pathway, EVs reflect the physiological and pathological status of their parent
Emine İncilay Torunoğlu, Zeynep Betül Sarı, Muhammed Emin Sarı, Erdi Can Aytar   +3 more
wiley   +1 more source

Nucleosome Linker Length and Distribution as Major Players in Epigenetic Regulation: Insights from Cryo-Electron Microscopy and Modeling of Retina Cell Maturation. [PDF]

DNA Cell Biol
Schlick T, Grigoryev S.
europepmc   +1 more source

Cryo‐EM Analysis of Adenovirus Vector Reveals Purification Conditions Leading to Loss of Viral Fiber Proteins and Reduced Infectivity

Biotechnology and Bioengineering, EarlyView.
ABSTRACT Vaccines and gene therapies require efficient delivery of genetic material to host cells. Viral vectors leverage viruses' ability to enter host cells to achieve this. Following the SARS‐CoV‐2 vaccine and novel gene therapies that utilize adenovirus vectors, there has been an increase in the demand for large‐scale production of vectors.
Betsy Widdicombe, Joseph D. Barritt, Nichakorn Pipatpadungsin, Braulio Carrillo Sanchez, Dale Stibbs, Lisa Cooper, Sarah L. Rouse, Daniel G. Bracewell   +7 more
wiley   +1 more source

Advances in cryo-electron microscopy (cryoEM) for structure-based drug discovery. [PDF]

Expert Opin Drug Discov
Rubach P, Majorek KA, Gucwa M, Murzyn K, Wlodawer A, Minor W.   +5 more
europepmc   +1 more source

Harnessing ferroptosis from multilayer defense networks to nanoplatforms for specific cancer therapy

BMEMat, EarlyView.
Nanomaterials target metabolically‐regulated ferroptosis for cancer therapy. Iron‐based or alternative nanoplatforms integrate ferroptosis with chemotherapy, immunotherapy, or radiotherapy. They enable stimulus‐responsive therapies (photothermal, photodynamic, sonodynamic) activated by near‐infrared, light, or ultrasound, achieving potent synergistic ...
Xinyue Xu, Xuejian Wang, Wenyan Jiang, Wan Hairul Anuar Kamaruddin, Chunyan Fang, Pengfei Zhang   +5 more
wiley   +1 more source

Structure of Aquifex aeolicus lumazine synthase by cryo-electron microscopy to 1.42 Å resolution. [PDF]

IUCrJ
Savva CG, Sobhy MA, De Biasio A, Hamdan SM.   +3 more
europepmc   +1 more source

Cryo-electron microscopy in the study of virus entry and infection. [PDF]

Front Mol Biosci
Dutta M, Acharya P.
europepmc   +1 more source

Correction of preferred orientation-induced distortion in cryo-electron microscopy maps. [PDF]

Sci Adv
Zhu D, Cao W, Li J, Wu C, Cao D, Zhang X.   +5 more
europepmc   +1 more source

Purification and Cryo-Electron Microscopy Analysis of Bacterial Appendages. [PDF]

Bio Protoc
Sanchez JC, Baumgardt JK, Wright ER.
europepmc   +1 more source

Structural insight into the DNMT1 reaction cycle by cryo-electron microscopy. [PDF]

PLoS One
De I, Weidenhausen J, Concha N, Müller CW.   +3 more
europepmc   +1 more source