Results 151 to 160 of about 108,976 (266)
Andrology, EarlyView.ABSTRACT Background Testicular germ cell tumours (TGCT) are the most common malignancies among young men and represent a major threat to reproductive health. Both the disease itself and oncological treatments, particularly chemotherapy, can compromise spermatogenesis and semen quality.
Ondrej Sanovec +18 more
wiley +1 more source
Artificial Organs, EarlyView.The graphical abstract illustrates our rapid PI‐based spheroid viability assay: hepatocyte spheroids are formed and stained with AO/PI, imaged after a 15‐min incubation, and analyzed for PI brightness normalized to area. This metric correlates strongly with functional urea/DNA output, validating PI intensity as a fast, reliable indicator of spheroid ...
Michael G. Megaly +11 more
wiley +1 more source
Out There No One Has a Right to Die
Bioethics, EarlyView.ABSTRACT The eventual goal of space exploration is to colonize exoplanets and their moons outside our solar system. This is a dangerous and immoral endeavour. The extraterrestrial life forms encountered would be hostile, vulnerable or both, and the descendants of the original pioneers would be involuntarily exposed to hazardous conditions and ...
Matti Häyry
wiley +1 more source
British Journal of Pharmacology, EarlyView.IS39, a novel non‐peptide PKR1 agonist, confers cardioprotection against doxorubicin‐induced toxicity. IS39 activates PKR1‐mediated pro‐survival signalling in cardiomyocytes, reducing reactive oxygen species (ROS), DNA damage and fibrosis markers. In vivo, IS39 preserves cardiac geometry and function in mice exposed to chronic doxorubicin challenge ...
Anais Audebrand +8 more
wiley +1 more source
Clinical Challenges in Transition to Adult Care for Young People With Endocrinopathies
Clinical Endocrinology, EarlyView.ABSTRACT The complexity of transition of pediatric patients to adult care is well recognized, with a multidisciplinary approach widely agreed to be essential. Despite extensive existing literature in this area, practical guidance as to the management of specific medical aspects and how to address these with patients and families is lacking, with little
Margaret Zacharin, Quynh‐Nhu Nguyen
wiley +1 more source
Cryopreservation duration does not affect pregnancy or neonatal outcomes in single high-quality blastocyst transfers: a multicenter retrospective study. [PDF]
Front Endocrinol (Lausanne)He T +8 more
europepmc +1 more source
Advancing conservation breeding programs for marine invertebrates
Conservation Biology, EarlyView.Abstract In the face of ecosystem change and biodiversity loss caused by climate change and other stressors, conservation breeding, or captive breeding, with the aim of reintroduction for wild population recovery, is an emerging tool for preventing species’ extinction and rehabilitating ecosystems.
Elora H. López‐Nandam +3 more
wiley +1 more source
Fertility preservation in women with endometriosis: How, when, and for whom? [PDF]
J Int Med ResKalaitzopoulos DR, Kohl Schwartz AS.
europepmc +1 more source
Cell Proliferation, EarlyView.The hfPSC‐LCs could be established from naïve hESCs, conventional hESCs, hiPSCs, and human blastocysts. The hfPSC‐LCs hold robust capacity for three germ layers, hPGCLCs, and hALPCs. ABSTRACT Human embryos undergo pivotal morphogenetic remodelling shortly after implantation. The understanding of this crucial stage is severely impeded by the scarcity of
Xiaoxiao Wang +11 more
wiley +1 more source
European Journal of Haematology, EarlyView.ABSTRACT Introduction Cryopreservation of peripheral‐blood‐derived hematopoietic stem and progenitor cells (PBSCs) has been used for decades, primarily for autologous transplantation. Now, in the era of new cellular therapies, the cryopreservation of allogeneic PBSCs may also become relevant.
Philipp Blüm +5 more
wiley +1 more source