Results 51 to 60 of about 19,122 (184)

In-cell NMR characterization of the secondary structure populations of a disordered conformation of α-Synuclein within E. coli cells [PDF]

, 2013
α-Synuclein is a small protein strongly implicated in the pathogenesis of Parkinson’s disease and related neurodegenerative disorders. We report here the use of in-cell NMR spectroscopy to observe directly the structure and dynamics of this protein ...
A Binolfi, Anthony W. P. Fitzpatrick, AS Maltsev, AS Morar, B Fauvet, B Fauvet, BC McNulty, C Camilloni, C Huang, C Lendel, C Li, C Li, CA Waudby, CA Waudby, Carlo Camilloni, Christopher A. Waudby, Christopher M. Dobson, CO Barnes, CR Bodner, CW Bertoncini, D Eliezer, D Sakakibara, DS Biggs, DS Burz, DS Wishart, DS Wishart, E Lescop, EJ De Genst, F Chiti, F Delaglio, F Ferrage, I Bertini, IR Booth, John Christodoulou, JR Allison, K Inomata, KM Slade, KR Metz, Lisa D. Cabrita, Michele Vendruscolo, MM Dedmon, MR Cookson, P Bernadó, P Sarder, P Schanda, PH Weinreb, Piero Andrea Temussi, RC Puetter, SF Gull, T Bartels, TS Ulmer, VN Uversky, VN Uversky, W Wang, WF Vranken, WS Davidson, Z Serber, Z Serber   +57 more
core   +5 more sources

Catalyst‐Free Mass Polymerization and Characterization of Bio‐Polyhydroxhyurethanes Based on Resorcinol Bis(Cyclocarbonate)

Macromolecular Materials and Engineering, EarlyView.
Non‐isocyanate polyhydroxyurethanes (PHUs) were synthesized from resorcinol bis(cyclocarbonate) and eco‐friendly diamines under mild, catalyst‐free conditions. The resulting polymers were extensively characterized for their structural, thermal, and mechanical properties, as well as processability and adhesion performance.
Federico Olivieri, Noemi Faggio, Giovanni Dal Poggetto, Chiara Santillo, Roberto Avolio, Rachele Castaldo, Mariacristina Cocca, Maria Emanuela Errico, Marino Lavorgna, Gennaro Gentile   +9 more
wiley   +1 more source

Quantitative Competition Binding of Fluorinated Ligands by Real‐Time 19F In‐Cell NMR to Assess Isoform Selectivity in Human Cells

Magnetic Resonance in Chemistry, EarlyView.
Real‐time in‐cell 19F NMR spectroscopy in a flow NMR bioreactor was used to monitor the binding of fluorinated compounds to three cytosolic carbonic anhydrase isoforms in living human cells. The simultaneous observation of the two ligands allowed for the quantitative ranking of their intracellular affinities by competition binding. This approach allows
Azzurra Costantino, Letizia Barbieri, Simone Giovannuzzi, Alessio Nocentini, Claudiu T. Supuran, Enrico Luchinat   +5 more
wiley   +1 more source

TECHNICAL DETAILS AND RESULTS OF CRYOABLATION IN PANCREATIC CANCER

Клиническая практика, 2016
Aim: To improve the results of treatment of terminal stage pancreatic cancer. Materials and methods. Since 2012 cryosurgery was performed in 45 patients - 20 men (44.4%) and 25 women (55.6%) with pancreatic cancer. With mean age of 59 ± 3 years. The head
D A Ionkin, Yu A Stepanova, A B Shurakova, A V Chzhao   +3 more
doaj   +1 more source

Flux Flow Effects in Annular Josephson Tunnel Junctions [PDF]

, 2019
We investigate Josephson flux-flow in annular Josephson tunnel junctions (AJTJs) under the application of magnetic fields generating finite-voltage steps in their current-voltage characteristics.
Koshelets, Valery P., Monaco, Roberto, Mygind, Jesper   +2 more
core   +2 more sources

Quantitative Imaging of Pyruvate Metabolism in a Patient With Anaplastic Thyroid Cancer

Magnetic Resonance in Medicine, EarlyView.
ABSTRACT Purpose Magnetic resonance imaging using hyperpolarized (HP) [1‐13C]‐pyruvate enables assessment of pyruvate metabolism in vivo and offers new insight into metabolic changes in response to cancer therapy. Widely used semi‐quantitative metrics of pyruvate metabolism can be affected by physiological factors that are extrinsic to intracellular ...
James A. Bankson, Joshua S. Niedzielski, Collin J. Harlan, Yunyun Chen, Christopher M. Walker, Philip L. Lorenzi, Lin Tan, Vikas Kundra, Matthew E. Merritt, Mukundan Ragavan, Dawid Schellingerhout, Renjie He, Yao Ding, Sahana Datar, Qing Wang, Christine B. Peterson, Clifton D. Fuller, Vlad C. Sandulache, Stephen Y. Lai   +18 more
wiley   +1 more source

A Surgical Cryoprobe for Targeted Transcorneal Freezing and Endothelial Cell Removal

Journal of Ophthalmology, 2017
Purpose. To examine the effects of transcorneal freezing using a new cryoprobe designed for corneal endothelial surgery. Methods. A freezing console employing nitrous oxide as a cryogen was used to cool a series of different cryoprobe tip designs made of
Alina Akhbanbetova, Shinichiro Nakano, Stacy L. Littlechild, Robert D. Young, Madara Zvirgzdina, Nigel J. Fullwood, Ian Weston, Philip Weston, Shigeru Kinoshita, Naoki Okumura, Noriko Koizumi, Andrew J. Quantock   +11 more
doaj   +1 more source

A comparative evaluation : oral leukoplakia surgical management using diode laser, CO2 laser, and cryosurgery [PDF]

, 2017
The comparatively evaluate the three surgical treatment modalities namely cryosurgery, diode and CO2 laser surgery in terms of healing outcomes on the day of surgery, first and second week post operatively and recurrence at the end of 18 months was ...
Natekar, Madhukar, Panicker, Archana G, Prashanth, Nagesh-Tavane, Raghuveer, Hosahallli-Puttaiah, Rangan, Vinod, Rayapati, Dilip-Kumar, Shobha, Eshwara-Singh   +6 more
core   +1 more source

Assignments of backbone 1H, 13C and 15N resonances in H-Ras (1–166) complexed with GppNHp at physiological pH [PDF]

, 2012
The small GTPase Ras is an important signaling molecule acting as a molecular switch in eukaryotic cells. Recent findings of global conformational exchange and a putative allosteric binding site in the G domain of Ras opened an avenue to understanding ...
Kovriguine, Evgueni, O\u27Connor, Casey
core   +1 more source

"Fingertip" cryoprobe assisted orbital tumour extraction [PDF]

British Journal of Ophthalmology, 2005
Cryoprobes are used to grasp, provide traction, and facilitate orbital tumour removal.1–4 Standard ophthalmic cryoprobe tips are typically rounded and offer small surface areas for cryo-adhesion. I describe a new spatulated cryotherapy probe with a large oval and uniform surface area for adhesion and subsequent traction. This report uses photography to
openaire   +2 more sources