Results 71 to 80 of about 108,443 (306)
Genome signatures, self-organizing maps and higher order phylogenies: a parametric analysis [PDF]
, 2007 Genome signatures are data vectors derived from the compositional statistics of DNA. The self-organizing map (SOM) is a neural network method for the conceptualisation of relationships within complex data, such as genome signatures.
Gatherer, Derek
core +4 more sources
Invasion of the central nervous system by Cryptococcus neoformans requires a secreted fungal metalloprotease. [PDF]
, 2014 UnlabelledCryptococcus spp. cause life-threatening fungal infection of the central nervous system (CNS), predominantly in patients with a compromised immune system.
Bautos, Jennifer M +7 more
core +2 more sources
American Journal of Medical Genetics Part A, EarlyView.ABSTRACT The MT‐ATP6 gene m.8993T>G pathogenic variant has been associated with Leigh syndrome, especially in patients exhibiting a high degree of heteroplasmy. Although patients may present with a wide phenotypic spectrum, characteristic findings include bilateral, symmetric hyperintensities in the basal ganglia and brainstem on brain MRI ...
Ramya Treitel +2 more
wiley +1 more source
Cryptococcal Meningitis Diagnostics and Screening in the Era of Point-of-Care Laboratory Testing. [PDF]
, 2019 Over the past ten years, standard diagnostics for cryptococcal meningitis in HIV-infected persons have evolved from culture to India ink to detection of cryptococcal antigen (CrAg), with the recent development and distribution of a point-of-care lateral ...
Beyene, T +5 more
core +1 more source
Msphere, 2019 Extracellular vesicles (EVs) are fundamental components of the physiology of cells from all kingdoms. In pathogenic fungi, they participate in important mechanisms of transfer of antifungal resistance and virulence, as well as in immune stimulation and ...
F. C. Reis +14 more
semanticscholar +1 more source
Cerebrospinal Fluid Metabolome in Central Nervous System Infections: A Study of Diagnostic Accuracy
Annals of Neurology, EarlyView.Objective To assess the diagnostic accuracy of metabolites in cerebrospinal fluid (CSF) for central nervous system (CNS) infections. Methods Patients were derived from three prospective cohort studies in the Netherlands. All studies included adults suspected of a CNS infection who underwent a diagnostic lumbar puncture.
Steven L. Staal +7 more
wiley +1 more source
Cryptococcus–Epithelial Interactions [PDF]
Journal of Fungi, 2017 The fungal pathogen, Cryptococcus neoformans, causes devastating levels of morbidity and mortality. Infections with this fungus tend to be predominantly in immunocompromised individuals, such as those with HIV. Infections initiate with inhalation of cryptococcal cells and entry of the pathogen into the lungs. The bronchial epithelial cells of the upper
openaire +4 more sources
Melanogenesis in Cryptococcus neoformans [PDF]
Microbiology, 1988 Melanogenesis in Cryptococcus neoformans begins with the oxidation of dihydroxyphenylalanine by the enzyme phenol oxidase. The succeeding steps are very rapid. Two intermediates, dopachrome and 5,6-dihydroxyindole, have been isolated and characterized by high performance liquid chromatography. A pathway of melanin formation in C. neoformans is proposed,
Itzhack Polacheck, Kyung J. Kwon-Chung
openaire +3 more sources
In vitro anidulafungin activity against yeasts – system and disseminated mycosis pathogens
Онкогематология, 2015 We analyzed susceptibility to anidulafungin of yeasts clinical strains of Candida (14 species), Cryptococcus (1 species), Geotrichum (1 species), Rhodotorula (1 species) and Saccharomyces (1 species).
A. B. Kulko
doaj +1 more source
Unraveling Melanin Biosynthesis and Signaling Networks in Cryptococcus neoformans
mBio, 2019 Melanins are dark green, brown, or black pigments that serve as antioxidant, reactive oxygen species (ROS) scavengers that protect fungal pathogens from radiation and host immune responses.
Dongpil Lee +6 more
semanticscholar +1 more source