Results 1 to 10 of about 25,309 (112)

Direct Inhibition of T-Cell Responses by the Cryptococcus Capsular Polysaccharide Glucuronoxylomannan [PDF]

, 2006
The major virulence factor of the pathogenic fungi Cryptococcus neoformans and C. gattii is the capsule. Glucuronoxylomannan (GXM), the major component of the capsule, is a high-molecular-weight polysaccharide that is shed during cryptococcosis and can ...
Lam, Jennifer S, Levitz, Stuart M, Yauch, Lauren E   +2 more
core   +14 more sources

Galactoxylomannans of Cryptococcus neoformans [PDF]

Infection and Immunity, 1992
Galactoxylomannans (GalXMs) from single isolates of Cryptococcus neoformans serotypes A, B, and D were isolated from culture supernatants and then purified by affinity, ion-exchange, and gel-filtration chromatography. GalXMs are a group of closely related complex polysaccharides.
P G James, Robert Cherniak
openaire   +3 more sources

Melanogenesis in Cryptococcus neoformans [PDF]

Microbiology, 1988
Melanogenesis in Cryptococcus neoformans begins with the oxidation of dihydroxyphenylalanine by the enzyme phenol oxidase. The succeeding steps are very rapid. Two intermediates, dopachrome and 5,6-dihydroxyindole, have been isolated and characterized by high performance liquid chromatography. A pathway of melanin formation in C. neoformans is proposed,
Itzhack Polacheck, Kyung J. Kwon-Chung
openaire   +3 more sources

The capsule ofCryptococcus neoformans [PDF]

Virulence, 2018
The capsule of Cryptococcus neoformans is its dominant virulence factor and plays a key role in the biology of this fungus. In this essay, we focus on the capsule as a cellular structure and note the limitations inherent in the current methodologies available for its study.
Arturo Casadevall, Carolina Coelho, Radames J. B. Cordero, Quigly Dragotakes, Eric Jung, Raghav Vij, Maggie P. Wear   +6 more
openaire   +4 more sources

Automated Analysis of Cryptococcal Macrophage Parasitism Using GFP-Tagged Cryptococci [PDF]

, 2010
The human fungal pathogens Cryptococcus neoformans and C. gattii cause life-threatening infections of the central nervous system. One of the major characteristics of cryptococcal disease is the ability of the pathogen to parasitise upon phagocytic immune
A Casadevall, A Idnurm, AL Goldstein, B Bolanos, BJ Park, C Charlier, C Luberto, C Monari, CE Cross, DA Bobak, DL Goldman, DL Goldman, DL Oliveira, DL Toffaletti, E Brummer, EJ Byrnes 3rd, F Chretien, FM Griffin Jr, G Hu, GD Campbell, GS Bulmer, GS Bulmer, H Lee, H Ma, H Ma, H Ma, HF Nadrous, J Livet, Julian C. Rutherford, K Voelz, Kerstin Voelz, Kirsten Nielsen, L MacDougall, LA Knodler, LH Okagaki, M Alvarez, M Alvarez, M Alvarez, M Alvarez, M Del Poeta, M Feldmesser, M Feldmesser, M Shi, MC Lorenz, MF Miller, NC Shaner, P Ralph, R Bajpai, R Santangelo, R Velagapudi, RD Diamond, Robin C. May, S Geunes-Boyer, SC Tucker, SE Kidd, Simon A. Johnston, SM Levitz, TA Missall, TB Kechichian, TG Mitchell, TG Mitchell, TR Kozel, TW Christianson, X Dong, X Shao   +64 more
core   +10 more sources

Vomocytosis: Too Much Booze, Base, or Calcium? [PDF]

, 2019
Macrophages are well known for their phagocytic activity and their role in innate immune responses. Macrophages eat non-self particles, via a variety of mechanisms, and typically break down internalized cargo into small macromolecules.
Aaron, Alvarez, Alvarez, Artavanis-Tsakonas, Bain, Ben-Abdallah, Bielska, Blackstock, Boya, Bryan, Burch, Chang, Charlier, Chen, Cheng, Chu, Circu, Cox, Davis, De Leon-Rodriguez, De Leon-Rodriguez, Denham, Di, Diamond, Doshi, Dragotakes, Drew, Erb-Downward, Erwig, Evans, Feldmesser, Franchi, Fu, Gilbert, Gordon, Guerra, Gustafson, Haka, Han, Henson, Heo, Hibbs, Hoag, Hommel, Huang, Hybiske, Iwasaki, Johnston, Kjos, Kleinschek, Kruskal, Kusner, Lei, Leopold Wager, Levitz, Levitz, Lim, Liu, Lévêque, Ma, Maderna, May, Milam, Mosser, Murdock, Murray, Myers, Müller, Nel, Nicola, Nunes, Okagaki, O’Meara, Pauwels, Qiu, Rajasingham, Russell, Samantaray, Santiago-Tirado, Singh, Smith, Stukes, Stukes, Swisher, Tucker, Vashi, Voelz, Vu, Vu, Walkey, Wang, Wang, Watkins, Weiss, Wormley, Wozniak, Yates, Yoshida, Zaragoza   +98 more
core   +2 more sources

Micromorphology ofCryptococcus neoformans [PDF]

Journal of Bacteriology, 1967
Fine details of the internal and external morphology ofCryptococcus neoformansas seen in ultrathin sections are described and illustrated with electron micrographs. The capsule characteristic of this species contained microfibrils (30 to 40 A in diameter) that appeared to radiate from the cell wall and to coil and intertwine in various directions ...
Mercedes R. Edwards, Mercedes R. Edwards, Edward W. Lapa, Edward W. Lapa, William C. Ghiorse, William C. Ghiorse, Morris A. Gordon, Morris A. Gordon   +7 more
openaire   +3 more sources

Experimental modulation of capsule size in Cryptococcus neoformans [PDF]

, 2004
Experimental modulation of capsule size is an important technique for the study of the virulence of the encapsulated pathogen Cryptococcus neoformans.
A Casadevall, AM Macher, Arturo Casadevall, B Bolaños, C Tripp, CA D’Souza, DL Granger, DL Weinstein, EJ Anna, ES Jacobson, ES Jacobson, F Bergman, F Farhi, GL Love, J Rivera, JA Alspaugh, JG Cruickshank, JW Murphy, KJ Nyhus, M Feldmesser, M Littman, MA Dykstra, MJ Bjorn, O Zaragoza, O Zaragoza, Oscar Zaragoza, R Cherniak, SE Vartivarian, TR Kozel, TR Kozel, ZM Dong   +30 more
core   +3 more sources

RNA interference screening reveals host CaMK4 as a regulator of cryptococcal uptake and pathogenesis [PDF]

, 2017
Cryptococcus neoformans , the causative agent of cryptococcosis, is an opportunistic fungal pathogen that kills over 200,000 individuals annually. This yeast may grow freely in body fluids, but it also flourishes within host cells.
Doering, Tamara L, Hole, Camaron R, Khader, Shabaana A, Srikanta, Deepa, Williams, Matthew   +4 more
core   +2 more sources

Rim Pathway-Mediated Alterations in the Fungal Cell Wall Influence Immune Recognition and Inflammation [PDF]

, 2017
ACKNOWLEDGMENTS We acknowledge Jennifer Lodge, Woei Lam, and Rajendra Upadhya for developing and sharing the chitin and chitosan MTBH assay. We thank Todd Brennan of Duke University for providing MyD88-deficient mice.
Carol Munro, Chrissy M. Leopold Wager, Floyd L. Wormley, J. Andrew Alspaugh, Jeanette Wagener, Kyla S. Ost, Louise Walker, Michael Lorenz, Shannon K. Esher   +8 more
core   +3 more sources