Cryptococcus neoformans chitin synthase 3 plays a critical role in dampening host inflammatory responses [PDF]
, 2020 Cryptococcus neoformans is the most common disseminated fungal pathogen in AIDS patients, resulting in ∼200,000 deaths each year. There is a pressing need for new treatments for this infection, as current antifungal therapy is hampered by toxicity and/or
Hole, Camaron R +3 more
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Catecholamines and virulence of Cryptococcus neoformans [PDF]
Infection and Immunity, 1990 Cryptococcus neoformans was unable to utilize catecholamines (epinephrine, norepinephrine, or dopamine) as sole carbon or nitrogen sources. Therefore, catecholamines are not essential growth factors for this fungus and the brain is not a preferred nutritional niche for its growth with regard to catecholamines.
Y Platt, J Aronovitch, I Polacheck
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Titan cell production in Cryptococcus neoformans reshapes the cell wall and capsule composition during infection [PDF]
, 2018 This work was supported by the National Institutes of Health (R01AI080275 and R21AI22352), the NIH Fogarty International Center (R25TW009345), the University of Minnesota Center for Translational Science Institute (UL1TR000114), Wellcome Trust (086827 ...
Gow, Neil A R +5 more
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Differential antifungal activity of human and cryptococcal melanins with structural discrepancies [PDF]
, 2017 Indexación: Scopus.Melanin is a pigment found in all biological kingdoms, and plays a key role in protection against ultraviolet radiation, oxidizing agents, and ionizing radiation damage. Melanin exerts an antimicrobial activity against bacteria, fungi,
Correa, N. +8 more
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Invasion of the central nervous system by Cryptococcus neoformans requires a secreted fungal metalloprotease. [PDF]
, 2014 UnlabelledCryptococcus spp. cause life-threatening fungal infection of the central nervous system (CNS), predominantly in patients with a compromised immune system.
Bautos, Jennifer M +7 more
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Mammite à «Cryptococcus neoformans» [PDF]
Bulletin de l'Académie Vétérinaire de France, 1956 Ségretain G., Verge Jean, Drieux Henri, Mariat F., Paraf Alain, Labie C., Théron B. Mammite à «Cryptococcus neoformans». In: Bulletin de l'Académie Vétérinaire de France tome 109 n°1, 1956. pp. 33-41.
Ségretain, G. +6 more
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Cryptococcal choroiditis in advanced AIDS with clinicopathologic correlation. [PDF]
, 2018 PurposeTo describe a case of disseminated cryptococcal meningitis with multifocal choroiditis and provide optical coherence tomography (OCT) findings correlated with described histopathology in a patient with advanced acquired immunodeficiency syndrome ...
Aderman, Christopher M +5 more
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Ultrastructure of Cryptococcus neoformans
Acta Dermato-Venereologica, 1982 The ultrastructure of C. neoformans was studied in two cases of cutaneous cryptococcosis. Extracellular and intracellular fungi were observed. Their capsules and clear zones were thick and distinct, but their cytoplasmic organelles were not obvious. In macrophages, a few stages of fungal degeneration could be observed.
H, Hino, K, Takizawa, G, Asboe-Hansen
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Genetic complementation in Cryptococcus neoformans [PDF]
Journal of Bacteriology, 1986 A complementation test was devised for the fungus Cryptococcus neoformans. Complementation was signalled by the growth of prototrophic heterokaryons generated in crosses of the type aB X Ab, where a and b represent any two of the genetic markers ilv1, cys1, cys2, and cys3.
W. L. Whelan, Kyung J. Kwon-Chung
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Dynamic ploidy changes drive fluconazole resistance in human cryptococcal meningitis. [PDF]
, 2018 BACKGROUND: Cryptococcal meningitis (CM) causes an estimated 180,000 deaths annually, predominantly in sub-Saharan Africa, where most patients receive fluconazole (FLC) monotherapy. While relapse after FLC monotherapy with resistant strains is frequently
Berman, J +13 more
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