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Phenotypic switching in Cryptococcus neoformans [PDF]
Phenotypic switching has been described in serotype A and D strains ofCryptococcus neoformans. It occursin vivoduring chronic infection and is associated with differential gene expression and changes in virulence. The switch involves changes in the polysaccharide capsule and cell wall that affect the yeast's ability to resist phagocytosis. In addition,
A, Guerrero +3 more
openaire +2 more sources
Insights Into the Susceptibility of Fungal Infection and STAT3 Genetic Mutations
ABSTRACT Signal transducer and activator of transcription 3 (STAT3) is a key transcription factor that regulates a spectrum of genes and signalling pathways critical for the antifungal immune response. Mutations in the STAT3 gene confer susceptibility to severe and recurrent fungal infections, predominantly via disruption of interleukin‐17 (IL‐17 ...
Fengming Li +5 more
wiley +1 more source
Naganishia diffluens, a rare non‐neoformans cryptococcal species, was identified by PCR sequencing as the causative agent of oral cryptococcosis in a 31‐year‐old Iranian man with β‐thalassemia. This case represents the first documented instance of oral infection by N.
Zahra Yahyazadeh +13 more
wiley +1 more source
Cryptococcus neoformans is the major cause of fungal meningitis, a potentially lethal mycosis. Bird excreta can be considered a significant environmental reservoir of this species in urban areas, thirty-three samples of pigeon excreta were collected ...
Mariceli Araujo Ribeiro +1 more
doaj +1 more source
Ruthenium(II) (Ru(II)) pyrazolyl–pyridine half‐sandwich complexes (C1–C6) were synthesized and structurally characterized as prospective metalloantibiotics. Screening through the Community for Open Antimicrobial Drug Discovery (CO‐ADD) revealed selective activity against Acinetobacter baumannii, with favorable cytotoxicity profiles. Biophysical studies
M. Cassiem Joseph +7 more
wiley +1 more source
A Genomic Catalog of Migratory Microbiomes from Wild Birds across China's Habitats
ABSTRACT Migratory birds play an important role in the spread of antimicrobial resistance (AMR); however, gaps in surveillance data from vital regions along migratory flyways across China limit the detection of emergent threats. Here, we assembled 340 metagenomes from 52 bird species covering 11 provincial administrative districts in China, presenting ...
Yanan Wang +13 more
wiley +1 more source
Immunomodulatory Role of Capsular Polysaccharides Constituents of Cryptococcus neoformans
Cryptococcosis is a systemic fungal infection caused by Cryptococcus neoformans. In immunocompetent patients, cryptococcal infection is often confined to the lungs. In immunocompromised individuals, C.
Debora Decote-Ricardo +11 more
doaj +1 more source
ABSTRACT In patients with EGFR‐mutant lung adenocarcinoma receiving gefitinib or other EGFR‐TKIs, the development of new pulmonary nodules should not be hastily attributed to disease progression; secondary pulmonary cryptococcosis should be considered in the differential diagnosis.
Yun Wang +7 more
wiley +1 more source
This research included study the effect of garlic and onion plants extracts(alcoholic and watery) in vitro in three different concentrations 15%,25%,35% and in vivo in experimental white mice .Research was performed by three experiments, first one was ...
Abd-Alshaheed D. A.
doaj +1 more source

