Results 61 to 70 of about 54,149 (255)
Cryptococcus species are life-threatening human fungal pathogens that cause cryptococcal meningoencephalitis in both immunocompromised and healthy hosts.
Çağri Ergin+9 more
doaj +1 more source
Population genomics and the evolution of virulence in the fungal pathogen Cryptococcus neoformans
Cryptococcus neoformans is an opportunistic fungal pathogen that causes approximately 625,000 deaths per year from nervous system infections. Here, we leveraged a unique, genetically diverse population of C.
C. Desjardins+13 more
semanticscholar +1 more source
Despite lacking DNMT3, EM‐seq revealed CpG methylation in the Colorado potato beetle. CUT&Tag analysis showed an association of H3K36me3 and H3K27ac with transcription, with H3K36me3 mirroring CpG methylation, demonstrating epigenetic flexibility.
Zoe M. Länger+6 more
wiley +1 more source
Induction of Broad-Spectrum Protective Immunity against Disparate Cryptococcus Serotypes
Cryptococcosis is a fungal disease caused by multiple Cryptococcus serotypes; particularly C. neoformans (serotypes A and D) and C. gattii (serotypes B and C). To date, there is no clinically available vaccine to prevent cryptococcosis.
Marley C. Caballero Van Dyke+15 more
doaj +1 more source
Cryptococcus neoformans is a significant fungal pathogen of immunocompromised patients. Many questions remain regarding the function of macrophages in normal clearance of cryptococcal infection and the defects present in uncontrolled cryptococcosis.
Aleksandra Bojarczuk+11 more
semanticscholar +1 more source
A Novel In Vitro Host−Pathogen Model for Felis catus and Sporothrix Zoonotic Species Investigation
ABSTRACT Hyperendemic zoonotic sporotrichosis, attributed to Sporothrix brasiliensis, presents a significant public health challenge in Brazil. Cats exhibit severe symptoms and high fungal loads, though their susceptibility is unclear. Sporothrix schenckii can also cause feline disease, primarily seen in Asia.
Gabriele Barros Mothé+10 more
wiley +1 more source
Systematic functional analysis of kinases in the fungal pathogen Cryptococcus neoformans
Cryptococcus neoformans is the leading cause of death by fungal meningoencephalitis; however, treatment options remain limited. Here we report the construction of 264 signature-tagged gene-deletion strains for 129 putative kinases, and examine their ...
Kyung-Tae Lee+28 more
semanticscholar +1 more source
A series of azomethine‐pyrazole derivatives bearing a para‐substituted azo‐phenyl ring is straightforwardly prepared. The new compounds display an elevated antifungal activity against various Candida species and Cryptococcus neoformans strains. DFT and molecular docking calculations are used to determine possible routes of action through interactions ...
María Isabel Murillo+8 more
wiley +1 more source
A capacidade de Cryptococcus spp produzir melanina em meios contendo compostos fenólicos é amplamente utilizada na identificação destas espécies no laboratório.
Reginaldo dos Santos Pedroso+3 more
doaj +1 more source
The ability to adapt to a changing environment provides a selective advantage to microorganisms. In the case of many pathogens, a large change in their environment occurs when they move from a natural setting to a setting within a human host and then ...
Kylie J. Boyce+5 more
semanticscholar +1 more source