Results 61 to 70 of about 14,401 (247)

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

Message passing variational autoregressive network for solving intractable Ising models

Communications Physics
Deep neural networks have been used to solve Ising models, including autoregressive neural networks, convolutional neural networks, recurrent neural networks, and graph neural networks.
Qunlong Ma, Zhi Ma, Jinlong Xu, Hairui Zhang, Ming Gao   +4 more
doaj   +1 more source

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

Time in cryptography

, 2020
Time travel has always been a fascinating topic in literature and physics. In cryptography, one may wonder how to keep data confidential for some time. In this dissertation, we will study how to make private information travel to the future. This dissertation consists of three parts: Timed-release encryption, witness encryption and self-encryption ...
openaire   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

IAGF: a dual-path collaborative inconsistency-aware global fusion network for multimodal sarcasm detection

Journal of King Saud University: Computer and Information Sciences
Multimodal sarcasm detection aims to identify ironic intent from textual and visual information, with the core challenge lying in capturing semantic inconsistencies between different modalities.
Yaxuan Wang, Bin Wei, Yuechuan Zhang, Hongyu Jing, Mingshu Zhang   +4 more
doaj   +1 more source

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

EEFDA: enabling efficient and fault-tolerant data aggregation scheme without TA in smart grid

Complex & Intelligent Systems
Smart grid can be effectively enhanced by user data, however, data breaches pose significant risks related to privacy violations and data misuse. To address this issue, fault-tolerant privacy-preserving data aggregation schemes can protect data privacy ...
Yuanyuan Wang, Liqiang Wu, Yiliang Han, Xuguang Wu, Ruifeng Li   +4 more
doaj   +1 more source

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

Backdoors in cryptography [PDF]

Diese Arbeit besteht aus zwei Teilen. Im ersten Teil erfolgt eine Systematisierung von Backdoors für kryptografische Verfahren, welche nur für den Angreifer effizient vom originalen Verfahren unterschieden werden können. Hierbei werden bereits bekannte Backdoors verallgemeinert, indem die Einbettung von Informationen getrennt von der Ausnutzung durch ...
openaire   +2 more sources