Results 111 to 120 of about 212,764 (321)

Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA

Molecular Oncology, EarlyView.
Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson, Anders Lade Nielsen, Boe Sandahl Sorensen   +2 more
wiley   +1 more source

Bootstrapping Optimization Techniques for the FINAL Fully Homomorphic Encryption Scheme

Information
With the advent of cloud computing and the era of big data, there is an increasing focus on privacy computing. Consequently, homomorphic encryption, being a primary technique for achieving privacy computing, is held in high regard.
Meng Wu, Xiufeng Zhao, Weitao Song
doaj   +1 more source

Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting

Molecular Oncology, EarlyView.
CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia, Noelia Moares, Wenjie Yi‐He, Rosa Luna‐Espejo, Ricardo Fernandez‐Cisnal, Javier Ocaña‐Cuesta, Juan P. Muñoz‐Miranda, Antonio Gabucio, Cecilia M. Fernandez‐Ponce, Francisco Garcia‐Cozar   +9 more
wiley   +1 more source

GAN-based pseudo random number generation optimized through genetic algorithms

Complex & Intelligent Systems
Pseudo-random number generators (PRNGs) are deterministic algorithms that generate sequences of numbers approximating the properties of random numbers, which are widely utilized in various fields.
Xuguang Wu, Yiliang Han, Minqing Zhang, Yu Li, Su Cui   +4 more
doaj   +1 more source

On some cryptographic properties of Boolean functions and their second-order derivatives [PDF]

, 2019
Augustine Musukwa, Massimiliano Sala, Marco Zaninelli   +2 more
openalex   +1 more source

Improving PARP inhibitor efficacy in bladder cancer without genetic BRCAness by combination with PLX51107

Molecular Oncology, EarlyView.
Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz, Anna L. Bartkowiak, Michael Rose, Nora Kolks, Patrick Petzsch, Vandana Solanki, Anne Stoffel, Bianca Faßbender, Leandra Lepping, Julka Volkamer, Karl Köhrer, Marc Seifert, Tokameh Mahmoudi, Tahlita C. M. Zuiverloon, Günter Niegisch, Michèle J. Hoffmann   +15 more
wiley   +1 more source

Motion vector‐domain video steganalysis exploiting skipped macroblocks

IET Image Processing
Video steganography has the potential to be used to convey illegal information, and video steganalysis is a vital tool to detect the presence of this illicit act.
Jun Li, Minqing Zhang, Ke Niu, Yingnan Zhang, Xiaoyuan Yang   +4 more
doaj   +1 more source

Mitigating Crossfire Attacks via Topology Spoofing Based on ENRNN-MTD

Applied Sciences
Crossfire attacks disrupt network services by targeting critical links of server groups, causing traffic congestion and server failures that prevent legitimate users from accessing services.
Dexian Chang, Xiaobing Zhang, Jiajia Sun, Chen Fang   +3 more
doaj   +1 more source

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

Reversible Data Hiding in Encrypted Images Based on Preprocessing-Free Variable Threshold Secret Sharing

Applied Sciences
To solve the limitations of reversible data hiding in encrypted domains (RDH-ED) that cannot be applied to a distributed variable security environment, a novel RDH-ED scheme based on variable threshold image secret sharing (VTSIS) is proposed. Initially,
Chao Jiang, Minqing Zhang, Xiong Zhang, Fuqiang Di   +3 more
doaj   +1 more source