Results 111 to 120 of about 1,805,236 (298)
Natural Crystal Structure for Generating Raman‐Like Orbital Angular Momentum States
Advanced ScienceCreation of structured light at‐source with determinate orbital angular momentum (OAM) states is a fascinating branch of modern optics, owing to their integrability, wavelength insensitivity, and high mode purity.
Tianxiang Meng +4 more
doaj +1 more source
Molecular Oncology, EarlyView.Loss of NAPRT promotes lung tumor initiation and growth through a noncanonical mechanism, independent of its role in NAD+ biosynthesis. Mechanistically, NAPRT depletion activates the mTORC2‐driven AKT/β‐catenin signaling axis to enhance clonogenic and invasive phenotypes. Furthermore, lung‐specific Naprt deletion significantly increases tumor burden in
Myung Joon Oh +11 more
wiley +1 more source
Molecular Oncology, EarlyView.In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico +5 more
wiley +1 more source
Molecular Oncology, EarlyView.The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim +17 more
wiley +1 more source
Proceedings of the National Academy of Sciences, 1929 Very little progress has been made during the last decade toward a theoretical understanding of the physical properties of matter in the solid state. The reasons for this stagnation are very clearly presented in a recent paper by A. Smekal.(1) According to Smekal, the properties of solids can be arranged in two large groups as follows.
openaire +3 more sources
CuI Thiolate Reactivity with Dioxygen: The Formation of CuII Sulfinate and CuII Sulfonate Species via a CuII Thiolate Intermediate [PDF]
, 2013 CuI(Py2NS) (1) is formed by addition of CuI to a solution of the pyridyl-thiol ligand N-(2-mercaptopropyl)- N,N-bis(2-pyridylmethyl)amine (Py2NSH).
Sub Crystal and Structural Chemistry +5 more
core +1 more source
Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation
Molecular Oncology, EarlyView.How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim +11 more
wiley +1 more source
Design and fabrication techniques for a mid-infrared photonic crystal defect cavity in indium antimonide [PDF]
, 2009 Simulation results and fabrication details are presented for a two-dimensional AlxGayIn1-x-ySb photonic crystal membrane defect cavity. Peak emission is predicted at λ = 3.372 with a Q factor of 26233 for an optimized membrane thickness of 1000 nm ...
Rarity, John +26 more
core +1 more source
Electron‐Lattice Synergistic Coordination for Boosting the Electro‐Optic Response of the Crystal
Advanced ScienceThe electro‐optic (E‐O) response is fundamental where the refractive index of materials can be modulated by the external electric field. Up to now, E‐O modulation has become a critical technology in photonics, quantum optics, modern communication, etc ...
Jinfeng Han +7 more
doaj +1 more source