Results 91 to 100 of about 1,805,236 (298)

Large modification of crystal-melt interface shape during Si crystal growth by using electromagnetic Czochralski method (EMCZ)

, 2022
S.252-256Large-diameter, high-quality Si wafers are required for further advance of ultra large-scale integrated circuit (ULSI) device processing. Therefore, a new crystal growth technique is needed to obtain large-diameter, high-quality Si crystals ...
Friedrich, J., Watanabe, M., Vizman, D., Müller, G.   +3 more
core   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Febuxostat–p-Toluenesulfonic Acid Multi-Component Crystal: Characterization, Crystal Growth and Elucidation of the Salt/Co-Crystal Nature

, 2023
The multi-component solid form of febuxostat (FEB) with p-toluenesulfonic acid was synthesized by solvent-drop grinding and cooling-evaporative crystallization and characterized by powder X-ray diffraction (XRPD), thermogravimetry (TGA), differential ...
Danny Stam, Doriana T. Ungur, Coca A. Iordache, Tudor L. Tamas, Mihaela M. Pop, Gustavo Santiso-Quinones, Alice Mija, Carmen Guguta   +7 more
core   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Crystal structure and collagen-binding site of immune inhibitory receptor LAIR-1: unexpected implications for collagen binding by platelet receptor GPVI [PDF]

, 2010
Leukocyte-associated immunoglobulinlike receptor-1 (LAIR-1), one of the most widely spread immune receptors, attenuates immune cell activation when bound to specific sites in collagen.
Meyaard, L., Crystal and Structural Chemistry, de Ruiter, T., van Ingen, H., Sub NMR Spectroscopy, Boelens, R., Brondijk, T.H.C., Sub Biochemistry of Membranes begr1-6-12, Farndale, R.W., Lebbink, R.J., Huizinga, E.G., NMR Spectroscopy, Sub Crystal and Structural Chemistry, NMR-spectroscopie, Wienk, H., Ballering, J., Biochemistry of membranes   +16 more
core   +1 more source

Secondary cold isostatic pressing-assisted pressureless sintering of high-density h-BN ceramics

Journal of Advanced Ceramics
Owing to its strong B–N covalent bonds and inferior dissolution–precipitation characteristics in selected liquid phases, densification of h-BN ceramics is generally achieved via pressure-assisted sintering techniques.
Shuxuan Wang, Yuqi Yang, Lei Yang, Xiaodong Li, Jiakai Cao, Gang He   +5 more
doaj   +1 more source

Temperature Dependence of the Thermal, Electrical Resistivity, Dielectric and Piezoelectric Properties of CaYAl3O7 Crystal

Crystals, 2018
Calcium yttrium aluminate (CaYAl3O7) crystal was grown and characterized in detail for high temperature piezoelectric sensors for the first time. The thermal properties of the CaYAl3O7 (CYAM) crystal were investigated systematically.
Yang Li, Zhitai Jia, Yanru Yin, Qiangqiang Hu, Wenxiang Mu, Jian Zhang, Xiaoqiang Yu, Xutang Tao   +7 more
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Crystal structure and luminescence of complexes of Eu(III) and Tb(III) with furan-2,5-dicarboxylate [PDF]

, 2012
Four new Ln(III) complexes (Ln = Eu, Tb) with furan-2,5-dicarboxylic acid (H2FDA) as a ligand have been synthesized and characterized in the solid state.
Sub Crystal and Structural Chemistry, Lutz, M., Rontgen participation programme, Bouwman, E., Akerboom, S., Fu, W.T.   +5 more
core   +1 more source

Branch-Chain-Rich Diisopropyl Ether with Steric Hindrance Facilitates Stable Cycling of Lithium Batteries at − 20 °C

Nano-Micro Letters
Highlights Branch chain-rich diisopropyl ether (DIPE) was selected as co-solvent of low-temperature electrolyte for lithium metal battery. The introduction of DIPE improved the disorder of electrolyte and the branch chains from DIPE exclude other ...
Houzhen Li, Yongchao Kang, Wangran Wei, Chuncheng Yan, Xinrui Ma, Hao Chen, Yuanhua Sang, Hong Liu, Shuhua Wang   +8 more
doaj   +1 more source