Results 81 to 90 of about 851,280 (268)

Electron‐Lattice Synergistic Coordination for Boosting the Electro‐Optic Response of the Crystal

open access: yesAdvanced Science
The electro‐optic (E‐O) response is fundamental where the refractive index of materials can be modulated by the external electric field. Up to now, E‐O modulation has become a critical technology in photonics, quantum optics, modern communication, etc ...
Jinfeng Han   +7 more
doaj   +1 more source

ON MOSAIC CRYSTALS

open access: yesProceedings of the National Academy of Sciences, 1929
Very little progress has been made during the last decade toward a theoretical understanding of the physical properties of matter in the solid state. The reasons for this stagnation are very clearly presented in a recent paper by A. Smekal.(1) According to Smekal, the properties of solids can be arranged in two large groups as follows.
openaire   +3 more sources

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

open access: yesMolecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu   +13 more
wiley   +1 more source

Bifunctional Design of Ferroelectric‐Order and Band‐Engineering in Cu:KTN Crystal for Extended Self‐Powered Photoelectric Response

open access: yesAdvanced Science
Photoelectric conversion in ferroelectric crystals can support many important applications in modern on‐chip technology, but suffering from two problems, low responsive current and narrow responsive range.
Yaqian Wang   +6 more
doaj   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

open access: yesMolecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi   +11 more
wiley   +1 more source

C2α‐carbanion‐protonating glutamate discloses tradeoffs between substrate accommodation and reaction rate in actinobacterial 2‐hydroxyacyl‐CoA lyase

open access: yesFEBS Open Bio, EarlyView.
Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn   +4 more
wiley   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

open access: yesFEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei   +3 more
wiley   +1 more source

Exon 7 splicing of ERα predicts poor prognosis and increases phenotypic heterogeneity in luminal a subtype breast cancer

open access: yesFEBS Open Bio, EarlyView.
ERα splice variant ERα∆7 lacks the C‐terminus, and its expression may change phenotypes of breast cancers. Our results showed that ERα∆7 is found in the luminal A subtype, and elevated ERα∆7 levels are linked to improved cell survival with lower proliferation and migration.
Long Wai Tsui   +10 more
wiley   +1 more source

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

open access: yesFEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill   +4 more
wiley   +1 more source

Wavelet-analysis for Laser Images of Blood Plasma

open access: yesAdvances in Electrical and Computer Engineering, 2011
The possibilities of the local wavelet-analysis of polarization-inhomogeneous laser image of human blood plasma were considered. The set of statistics, correlation and fractal parameters of the distributions of wavelet-coefficients that are characterize
ANGELSKY, A.-P.   +5 more
doaj   +1 more source

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