Results 71 to 80 of about 1,043,173 (301)

Computational design of a protein crystal [PDF]

Proceedings of the National Academy of Sciences, 2012
Protein crystals have catalytic and materials applications and are central to efforts in structural biology and therapeutic development. Designing predetermined crystal structures can be subtle given the complexity of proteins and the noncovalent interactions that govern crystallization.
Lanci, Christopher J, MacDermaid, Christopher M, Keng, Seung-gu, Acharya, Rudresh, North, Benjamin, Yang, Xi, DeGrado, William F, Qiu, X Jade, Saven, Jeffery G.   +8 more
openaire   +3 more sources

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

Design of mesoscopic photonic crystal waveguides

The Journal of Engineering, 2019
The authors numerically analyse the performance of a mesoscopic photonic crystal (MPhC) waveguide that could be exploited to develop a new class of routing elements and a cascadable circuitry taking advantage of the spatial and spectral reconfigurability
Benedetta Ferrara, Marco Grande, Giovanna Calò, Antonella D'Orazio, Vincenzo Petruzzelli, Beatrice Dagens, Beatrice Dagens, Antoine Monmayrant, Antoine Monmayrant, Olivier Gauthier-Lafaye, Giovanni Magno   +10 more
doaj   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Design of electromagnetic metasurface using two dimensional crystal nets

Scientific Reports, 2023
Metasurfaces are of great interest as they exhibit unique electromagnetic properties. Currently, metasurface design focuses on generating new meta-atoms and their combinations.
Jie Hou, Xiaohong Zhang, Ying Guo, Rui-Zhi Zhang, Meng Guo   +4 more
doaj   +1 more source

Inverse design of photonic crystal devices [PDF]

IEEE Journal on Selected Areas in Communications, 2005
This work deals with the inverse design in the field of photonic crystal based devices. Here an inverse method containing a fast and accurate simulation method integrated with a competent optimization method is presented. Two designs yielded from this conjunction of multiple scattering theory with a genetic algorithm is analyzed.
Hakansson, Andreas, Sanchez-Dehesa, Jose, Sanchis, Lorenzo   +2 more
openaire   +2 more sources

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Design of Photonic Crystal Membrane-Reflector-Based VCSELs

IEEE Photonics Journal, 2012
We present here the cavity design of distributed-Bragg-reflector-free ultracompact Fano-resonance photonic crystal membrane-reflector vertical-cavity surface-emitting lasers on silicon, which consists of a III-V quantum-well active region sandwiched in ...
D. Zhao, H. Yang, S. Chuwongin, J. H. Seo, Z. Ma, W. Zhou   +5 more
doaj   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source