Results 81 to 90 of about 1,125,262 (294)

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

Crystal structure of poly[[μ2-diaqua-diaqua-μ2-l-proline-κ2O:O′-strontium] dibromide]

Acta Crystallographica Section E: Crystallographic Communications, 2015
In the title coordination polymer, {[Sr(C5H9NO2)(H2O)4]Br2}n, the proline molecule exists in a zwitterionic form with one of the ring C atoms disordered over two sites [site-occupancy factors = 0.57 (6):0.43 (6)].
Selladurai Sathiskumar, Thangavelu Balakrishnan, Kandasamy Ramamurthi, Subbiah Thamotharan   +3 more
doaj   +1 more source

Protein crystal growth tray assembly [PDF]

, 1992
A protein crystal growth tray assembly includes a tray that has a plurality of individual crystal growth chambers. Each chamber has a movable pedestal which carries a protein crystal growth compartment at an upper end. The several pedestals for each tray
Carter, Daniel C., Miller, Teresa Y.
core   +1 more source

A Model for Isotropic Crystal Growth from Vapor on a Patterned Substrate

, 2001
We developed a consistent mathematical model for isotropic crystal growth on a substrate covered by the mask material with a periodic series of parallel long trenches where the substrate is exposed to the vapor phase.
Aoki, Bollen, Chernov, Coronell, Fini, Fujii, Gibbon, Greenspan, Herring, Hiruma, Kayser, Korgel, M Khenner, M.G Mauk, Marx, Mitchell, Mullins, Nam, Nishinaga, Nishinaga, Okumura, Osher, R.J Braun, Sakata, Sasaki, Sethian, Sudo, Thrush, Wong, Zybura   +29 more
core   +1 more source

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

Numerical simulation of convection and heat transfer in Czochralski crystal growth by multiple-relaxation-time LBM

AIP Advances, 2017
A two-dimensional axisymmetric swirling model based on the lattice Boltzmann method (LBM) in a pseudo Cartesian coordinate system is posited to simulate Czochralski (Cz) crystal growth in this paper.
Ding Liu, Weichao Huang, Ni Zhang
doaj   +1 more source

Crystal structure of catena-poly[[[triaquastrontium]-di-μ2-glycinato] dibromide]

Acta Crystallographica Section E: Crystallographic Communications, 2015
In the title coordination polymer, {[Sr(C2H5NO2)2(H2O)3]Br2}n, the Sr2+ ion and one of the water molecules are located on twofold rotation axes. The alkaline earth ion is nine-coordinated by three water O atoms and six O atoms of the carboxylate groups ...
Palanisamy Revathi, Thangavelu Balakrishnan, Kandasamy Ramamurthi, Subbiah Thamotharan   +3 more
doaj   +1 more source

Procedure to prepare transparent silica gels [PDF]

, 1987
This invention relates to the production of silica gels and in particular to a process for the preparation of silica gels which can be used as a crystal growth medium that simulates the convectionless environment of space to produce structurally perfect ...
Barber, Patrick G., Simpson, Norman R.
core   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source