Results 51 to 60 of about 3,157,293 (340)

The crystal structure of Pneumolysin at 2.0 Å resolution reveals the molecular packing of the pre-pore complex [PDF]

, 2015
Pneumolysin is a cholesterol-dependent cytolysin (CDC) and virulence factor of Streptococcus pneumoniae. It kills cells by forming pores assembled from oligomeric rings in cholesterol-containing membranes.
Andrew, Peter W, El-Mezgueldi, Mohammed, Faraj, Bayan H A, Gingras, Alexandre R, Lonnen, Rana, Marshall, Jamie E, Moody, Peter C E, Sheikh, Md. Arif, Wallis, Russell   +8 more
core   +1 more source

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

Molecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou, Zhen Wang, Fei Yang, Xiao Han, Lei Li, Huadong Liu   +5 more
wiley   +1 more source

Crystal structure of binase does not reflect its native conformation

Учёные записки Казанского университета: Серия Естественные науки, 2018
Cytotoxic ribonucleases (RNases) of the T1 family, including binase, the secreted guanyl-preferring RNase of Bacillus pumilus, are considered as promising agents of alternative anticancer chemotherapy.
E.V. Dudkina, V.V. Ulyanova, Yu.V. Surchenko, N.T. Nguen, A.I. Kolpakov, O.N. Ilinskaya   +5 more
doaj  

5-Fluoro-2-(2-fluorophenyl)-3-methylsulfinyl-1-benzofuran

Acta Crystallographica Section E, 2014
In the title compound, C15H10F2O2S, the dihedral angle between the plane of the benzofuran ring system (r.m.s. deviation = 0.015 Å) and that of the 2-fluorophenyl ring is 28.53 (6)°.
Hong Dae Choi, Pil Ja Seo, Uk Lee
doaj   +1 more source

Theory of Exciton Recombination from the Magnetically Induced Wigner Crystal

, 1996
We study the theory of itinerant-hole photoluminescence of two-dimensional electron systems in the regime of the magnetically induced Wigner crystal.
A. H. MacDonald, A. J. Shields, A. J. Turberfield, B. B. Goldberg, D. Heiman, D. Z. Liu, D. Z. Liu, E. M. Goldys, G. Finkelstein, H. A. Fertig, H. Buhmann, I. M. Ruzin, I. N. Harris, I. V. Kukushkin, I. V. Lerner, J. Zang, K. Kheng, L. D. Landau, L. P. Gor'kov, M. Dahl, N. A. Viet, N. R. Cooper, R. Cǒté, R. G. Clark, R. G. Clark, R. H. Morf, V. M. Apalkov, X. M. Chen   +27 more
core   +1 more source

Adenosine‐to‐inosine editing of miR‐200b‐3p is associated with the progression of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
A‐to‐I editing of miRNAs, particularly miR‐200b‐3p, contributes to HGSOC progression by enhancing cancer cell proliferation, migration and 3D growth. The edited form is linked to poorer patient survival and the identification of novel molecular targets.
Magdalena Niemira, Anna Skwarska, Karolina Chwialkowska, Agnieszka Ostrowska, Gabriela Sokolowska, Anna Zeller, Anna Erol, Andrzej Eljaszewicz, Bartosz Hanczaruk, Anna Michalska‐Falkowska, Agnieszka Tarasik, Joanna Reszec‐Gielazyn, Pawel Knapp, Marcin Moniuszko, Adam Kretowski   +14 more
wiley   +1 more source

An amide cyclophane

Acta Crystallographica Section E, 2014
The title compound, 8,18-dithia-2,6-diaza-13(1,4)-piperidina-1(1,2),4(1,3),7(1,2)-tribenzenaoctadecaphane-10,15-diyne-3,6-dione, C32H30N4O2S2, is composed of a relatively planar bis(2-mercaptophenyl)isophthalamide unit linked to a bridging 1,4-di(but-2 ...
Vijayan Viswanathan, Ayyavu Thirunarayanan, Perumal Rajakumar, Devadasan Velmurugan   +3 more
doaj   +1 more source

Crystal structure analysis of intermetallic compounds [PDF]

, 1968
Study concerns crystal structures and lattice parameters for a number of new intermetallic compounds. Crystal structure data have been collected on equiatomic compounds, formed between an element of the Sc, Ti, V, or Cr group and an element of the Co or ...
Conner, R. A., Jr., Downey, J. W., Dwight, A. E.   +2 more
core   +1 more source

Applied Symmetry for Crystal Structure Prediction

, 2019
This thesis presents an original open-source Python package called PyXtal (pronounced pi-crystal ) that generates random symmetric crystal structures for use in crystal structure prediction (CSP).
Fredericks, Scott William
core   +1 more source

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source