Results 61 to 70 of about 8,030,948 (310)

Crystal structure of serotonin

Acta Crystallographica Section E Crystallographic Communications, 2022
The title compound, serotonin or 5-hydroxytryptamine (5-HT) [systematic name: 3-(2-aminoethyl)-1H-indol-5-ol], C10H12N2O, has one molecule in the asymmetric unit. The conformation of the ethylamino side chain is gauche–gauche [Ca—Ca—Cm—Cm and Ca—Cm—Cm—N (a = aromatic, m = methylene) torsion angles = −64.2 (3) and −61.9 (2)°, respectively].
Marilyn Naeem, Andrew R. Chadeayne, James A. Golen, David R. Manke   +3 more
openaire   +3 more sources

A High-Resolution Crystal Structure that Reveals Molecular Details of Target Recognition by the Calcium-Dependent Lipopeptide Antibiotic Laspartomycin C [PDF]

, 2017
The calcium-dependent antibiotics (CDAs) are an important emerging class of antibiotics. The crystal structure of the CDA laspartomycin C in complex with calcium and the ligand geranyl-phosphate at a resolution of 1.28 Å is reported.
Crystal and Structural Chemistry, Kleijn, Laurens H. J., Afd Chemical Biology and Drug Discovery, Kleijn, L.H.J., Sastre Torano, Javier, Martin, N.I., Wood, Thomas M., Chemical Biology and Drug Discovery, Martin, Nathaniel I., Hedwich C. Vlieg, Javier Sastre Toraño, Vlieg, H.C., Wood, T.M., Sub Crystal and Structural Chemistry, Janssen, Bert J. C., Laurens H. J. Kleijn, Bert J. C. Janssen, Vlieg, Hedwich C., Thomas M. Wood, Nathaniel I. Martin, Sastre Toraño, J., Janssen, B.J.C.   +21 more
core   +2 more sources

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Crystal structure of fipronil [PDF]

Acta Crystallographica Section E Crystallographic Communications, 2017
The title compound, C12H4Cl2F6N4OS {systematic name: 5-amino-1-[2,6-dichloro-4-(trifluoromethyl)phenyl]-4-[(trifluoromethane)sulfinyl]-1H-pyrazole-3-carbonitrile}, is a member of the phenylpyrazole group of acaricides, and one of the phenylpyrazole group of insecticides.
Hyunjin Park, Jineun Kim, Eunjin Kwon, Tae Ho Kim   +3 more
openaire   +3 more sources

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

(4Z)-1-Benzyl-4-(2-oxopropylidene)-2,3,4,5-tetrahydro-1H-1,5-benzodiazepin-2-one

IUCrData, 2016
The title compound, C19H18N2O2, crystallizes with two independent molecules in the asymmetric unit which differ in conformation. The seven-membered ring adopts a `bowl' conformation with the benzyl group oriented away from the open face in one molecule ...
Mohamed Samba, Mohamed Said Minnih, Youssef Ramli, Younes Ouzidan, El Mokhtar Essassi, Joel T. Mague   +5 more
doaj   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

Crystal Structure of Agaricus bisporus Mushroom Tyrosinase: Identity of the Tetramer Subunits and Interaction with Tropolone [PDF]

, 2011
Tyrosinase catalyzes the conversion of phenolic compounds into their quinone derivatives, which are precursors for the formation of melanin, a ubiquitous pigment in living organisms.
Dijkstra, B.W., Dijkstra, Bauke W., Weijn, A., Bauke W. Dijkstra, Amrah Weijn, Wangsa T. Ismaya, Ismaya, Wangsa T.,, Rozeboom, Henriette J.; id_orcid, Dijkstra, Bauke W.,, Rozeboom, H.J., Jurriaan J. Mes, Harry J. Wichers, Ismaya, Wangsa T., Weijn, Amrah,, Mes, J.J., Ismaya, W.T., Fusetti, F., Wichers, Harry J.,, Fabrizia Fusetti, Mes, Jurriaan J., Fusetti, Fabrizia,, Wichers, Harry J., Fusetti, Fabrizia, Mes, Jurriaan J.,, Wichers, H.J., Rozeboom, Henriette J., Henriëtte J. Rozeboom, Rozeboom, Henriëtte J.,, Weijn, Amrah   +28 more
core   +3 more sources

Salmonella lipopolysaccharide‐containing supported lipid bilayers as platforms to study bacteriophage interactions

FEBS Letters, EarlyView.
We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace, Alyssa Borges, Charles Arnaud, Tove Karlsson, Nina K. Bröker, Stefanie Barbirz, Marta Bally   +6 more
wiley   +1 more source

Carbon nitride quantum dots decorated with cyano groups for boosting photocatalytic hydrogen peroxide production

Green Energy & Environment
The photocatalytic hydrogen peroxide (H2O2) production by graphitic carbon nitride is a sustainable and environment-benign alternative approach of conventional anthraquinone autoxidation technology, but it is great challenges to promote two-electron O2 ...
Ke Kong, Hong Zhong, Dejian Chen, Fushuai Zhang, Xiaoju Li, Ruihu Wang   +5 more
doaj   +1 more source