Results 81 to 90 of about 8,030,948 (310)

Crystal structure of binase does not reflect its native conformation

Учёные записки Казанского университета: Серия Естественные науки, 2018
Cytotoxic ribonucleases (RNases) of the T1 family, including binase, the secreted guanyl-preferring RNase of Bacillus pumilus, are considered as promising agents of alternative anticancer chemotherapy.
E.V. Dudkina, V.V. Ulyanova, Yu.V. Surchenko, N.T. Nguen, A.I. Kolpakov, O.N. Ilinskaya   +5 more
doaj  

Synthesis, molecular and crystal structures of 4-amino-3,5-difluorobenzonitrile, ethyl 4-amino-3,5-difluorobenzoate, and diethyl 4,4′-(diazene-1,2-diyl)bis(3,5-difluorobenzoate)

Acta Crystallographica Section E: Crystallographic Communications
The crystal structures of two intermediates, 4-amino-3,5-difluorobenzonitrile, C7H4F2N2 (I), and ethyl 4-amino-3,5-difluorobenzoate, C9H9F2NO2 (II), along with a visible-light-responsive azobenzene derivative, diethyl 4,4′-(diazene-1,2-diyl)bis(3,5 ...
Egor M. Novikov, Jesus Guillen Campos, Javier Read de Alaniz, Marina S. Fonari, Tatiana V. Timofeeva   +4 more
doaj   +1 more source

2-[4,5-Bis(4-bromophenyl)-1-(4-tert-butylphenyl)-1H-imidazol-2-yl]-4,6-dichlorophenol

IUCrData, 2019
In the title compound, C31H24Br2Cl2N2O, the dihedral angles subtended by the tert-butyl-phenyl, 4,6-dichlorophenol and 4-bromophenyl (×2) rings are 70.7 (3), 8.1 (3), 28.1 (3) and 84.2 (3)°, respectively.
S. Devika, K. N. Shraddha, Noor Shahina Begum   +2 more
doaj   +1 more source

Crystal structure of cyproconazole [PDF]

Acta Crystallographica Section E Crystallographic Communications, 2015
The title compound [systematic name: 2-(4-chlorophenyl)-3-cyclopropyl-1-(1H-1,2,4-triazol-1-yl)butan-2-ol], C15H18ClN3O, is a conazole fungicide. The asymmetric unit comprises two enantiomeric pairs (moleculesAandB) in which the dihedral angles between the chlorophenyl and triazole rings are 46.54 (9) (moleculeA) and 67.03 (8)° (moleculeB).
Gihaeng Kang, Jineun Kim, Eunjin Kwon, Tae Ho Kim   +3 more
openaire   +3 more sources

FolX from Pseudomonas aeruginosa is octameric in both crystal and solution [PDF]

, 2012
FolX encodes an epimerase that forms one step of the tetrahydrofolate biosynthetic pathway, which is of interest as it is an established target for important drugs.
Byron, Olwyn, Gabrielsen, M., Beckham, K.S.H., Cogdell, R.J., Roe, A.J., Gabrielsen, Mads, Roe, Andrew J., Byron, O., Beckham, Katherine S.H., Cogdell, Richard J.   +9 more
core   +1 more source

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

N1-[(1H-Imidazol-2-yl)methylidene]-N4-phenylbenzene-1,4-diamine

Acta Crystallographica Section E, 2014
The title compound, C16H14N4, is non-planar with dihedral angles between the planes of the imidazole and phenylenediamine rings of 30.66 (4)° and between the planes of the phenylenediamine and N-phenyl rings of 56.63 (7)°.
Md. Serajul Haque Faizi, Ashraf Mashrai, M. Shahid, Musheer Ahmad   +3 more
doaj   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

3-Cyano-N-methylpyridinium perchlorate

Acta Crystallographica Section E, 2014
In the crystal of the title molecular salt, C7H7N2+·ClO4−, the components are linked by C—H...O and C—H...N interactions, generating zigzag chains running parallel to [100].
Cameron A. McCormick, Vu D. Nguyen, Lynn V. Koplitz, Joel T. Mague   +3 more
doaj   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source