Results 81 to 90 of about 19,580,563 (395)

The crystal structure of [PDF]

Solid State Communications, 2010
9 pages, 2 figures, 3 ...
Catrin Löhnert, Marcus Tegel, Dirk Johrendt   +2 more
openaire   +2 more sources

Multidimensional OMICs reveal ARID1A orchestrated control of DNA damage, splicing, and cell cycle in normal‐like and malignant urothelial cells

Molecular Oncology, EarlyView.
Loss of the frequently mutated chromatin remodeler ARID1A, a subunit of the SWI/SNF cBAF complex, results in less open chromatin, alternative splicing, and the failure to stop cells from progressing through the cell cycle after DNA damage in bladder (cancer) cells. Created in BioRender. Epigenetic regulators, such as the SWI/SNF complex, with important
Rebecca M. Schlösser, Florian Krumbach, Eyleen Corrales, Geoffroy Andrieux, Christian Preisinger, Franziska Liss, Alexandra Golzmann, Melanie Boerries, Kerstin Becker, Ruth Knüchel, Stefan Garczyk, Bernhard Lüscher   +11 more
wiley   +1 more source

Spontaneous resolution and crystal structure of (2S)-2-(3-nitrophenyl)-3-phenyl-2,3,5,6-tetrahydro-4H-1,3-thiazin-4-one; crystal structure of rac-2-(4-nitrophenyl)-3-phenyl-2,3,5,6-tetrahydro-4H-1,3-thiazin-4-one

Acta Crystallographica Section E: Crystallographic Communications, 2018
The crystal structures of isomeric rac-2-(4-nitrophenyl)-3-phenyl-2,3,5,6-tetrahydro-4H-1,3-thiazin-4-one (C16H14N2O3S) (1) and (2S)-2-(3-nitrophenyl)-3-phenyl-2,3,5,6-tetrahydro-4H-1,3-thiazin-4-one (C16H14N2O3S) (2) are reported here.
Hemant P. Yennawar, Heather G. Bradley, Kristen C. Perhonitch, Haley E. Reppert, Lee J. Silverberg   +4 more
doaj   +1 more source

A nucleotide‐independent, pan‐RAS‐targeted DARPin elicits anti‐tumor activity in a multimodal manner

Molecular Oncology, EarlyView.
We report a Designed Ankyrin Repeat Protein that binds and inhibits RAS proteins, which serve as central cell signaling hubs and are essential for the progression of many cancers. Its unique feature is that it does not discriminate between different RAS isoforms or mutations and is capable of binding to RAS in both its active (GTP‐bound) and inactive ...
Jonas N. Kapp, Wouter P. R. Verdurmen, Jonas V. Schaefer, Kari Kopra, Gabriela Nagy‐Davidescu, Elodie Richard, Marie‐Julie Nokin, Patrick Ernst, Rastislav Tamaskovic, Martin Schwill, Ralph Degen, Claudia Scholl, David Santamaria, Andreas Plückthun   +13 more
wiley   +1 more source

Synthesis, molecular and crystal structures of 4-amino-3,5-difluorobenzonitrile, ethyl 4-amino-3,5-difluorobenzoate, and diethyl 4,4′-(diazene-1,2-diyl)bis(3,5-difluorobenzoate)

Acta Crystallographica Section E: Crystallographic Communications
The crystal structures of two intermediates, 4-amino-3,5-difluorobenzonitrile, C7H4F2N2 (I), and ethyl 4-amino-3,5-difluorobenzoate, C9H9F2NO2 (II), along with a visible-light-responsive azobenzene derivative, diethyl 4,4′-(diazene-1,2-diyl)bis(3,5 ...
Egor M. Novikov, Jesus Guillen Campos, Javier Read de Alaniz, Marina S. Fonari, Tatiana V. Timofeeva   +4 more
doaj   +1 more source

Crystal structure prediction via particle-swarm optimization [PDF]

, 2010
We have developed a method for crystal structure prediction from ``scratch'' through particle-swarm optimization (PSO) algorithm within the evolutionary scheme.
Yanchao Wang, Jian Lv, Li Zhu, Yanming Ma   +3 more
semanticscholar   +1 more source

EGFR‐STAT3 activation provides a therapeutic rationale for targeting aggressive ETV1‐positive prostate cancer

Molecular Oncology, EarlyView.
Cotargeting EGFR and STAT3 with Erlotinib and TTI‐101 impairs both 2D and 3D growth of ETV1‐overexpressing prostate cancer cells by disrupting a self‐sustaining ETV1–EGFR positive feedback loop that promotes EGFR and STAT3 expression and phosphorylation (activation).
Elsa Gomes Paiva, Bernardo Orr, Ana Azeredo, Andreia Brandão, Manuel R. Teixeira, Paula Paulo   +5 more
wiley   +1 more source

2-[4,5-Bis(4-bromophenyl)-1-(4-tert-butylphenyl)-1H-imidazol-2-yl]-4,6-dichlorophenol

IUCrData, 2019
In the title compound, C31H24Br2Cl2N2O, the dihedral angles subtended by the tert-butyl-phenyl, 4,6-dichlorophenol and 4-bromophenyl (×2) rings are 70.7 (3), 8.1 (3), 28.1 (3) and 84.2 (3)°, respectively.
S. Devika, K. N. Shraddha, Noor Shahina Begum   +2 more
doaj   +1 more source

5-Fluoro-3-(1H-indol-3-ylmethyl)-1H-indole

IUCrData, 2023
The title compound, C17H13FN2, was synthesized as a potential ligand for the construction of metal–organic frameworks. The two indole motifs present two potential coordination modes.
Guozhe Guo
doaj   +1 more source

Report on the sixth blind test of organic crystal structure prediction methods

Acta Crystallographica. Section B: Structural Science, Crystal Engineering and Materials, 2016
The results of the sixth blind test of organic crystal structure prediction methods are presented and discussed, highlighting progress for salts, hydrates and bulky flexible molecules, as well as on-going challenges.
A. Reilly, R. Cooper, C. Adjiman, S. Bhattacharya, A. D. Boese, J. Brandenburg, P. J. Bygrave, Rita Bylsma, Josh E Campbell, R. Car, D. Case, R. Chadha, J. Cole, K. Cosburn, H. Cuppen, Farren Curtis, G. Day, Robert A. DiStasio Jr., A. Dzyabchenko, B. P. van Eijck, D. Elking, J. A. van den Ende, J. Facelli, M. Ferraro, L. Fusti-Molnar, C. Gatsiou, T. S. Gee, R. de Gelder, L. Ghiringhelli, H. Goto, S. Grimme, Rui Guo, D. Hofmann, J. Hoja, Rebecca K. Hylton, Luca Iuzzolino, Wojciech Jankiewicz, Daniël T. de Jong, J. Kendrick, Niek J. J. de Klerk, Hsin-Yu Ko, L. Kuleshova, Xiayue Li, Sanjaya Lohani, F. Leusen, Albert M. Lund, Jian Lv, Yanming Ma, N. Marom, A. Masunov, Patrick McCabe, D. McMahon, H. Meekes, Michael P. Metz, A. Misquitta, S. Mohamed, B. Monserrat, R. Needs, M. Neumann, J. Nyman, S. Obata, H. Oberhofer, A. Oganov, A. Orendt, G. I. Pagola, C. Pantelides, Chris J. Pickard, R. Podeszwa, L. Price, S. Price, A. Pulido, Murray G. Read, K. Reuter, E. Schneider, C. Schober, G. P. Shields, Pawanpreet Singh, I. Sugden, K. Szalewicz, Christopher R. Taylor, A. Tkatchenko, M. Tuckerman, Francesca Vacarro, Manolis Vasileiadis, Á. Vázquez-Mayagoitia, Leslie Vogt, Yanchao Wang, Rona E. Watson, Gilles A. de Wijs, Jack Yang, Q. Zhu, C. Groom   +91 more
semanticscholar   +1 more source