Results 91 to 100 of about 622,957 (315)

Crystal structure of a DNA containing the planar, phenoxazine-derived bi-functional spectroscopic probe Ç

, 2011
Electron Paramagnetic Resonance (EPR) spectroscopy and fluorescence spectroscopy are complementary biophysical techniques used to examine the structure and dynamics of macromolecules.
Reginsson, Gunnar Widtfeldt, Olav Schiemann, Cekan, Pavol, Shelke, Sandip A., Adrian R. Ferré-D’Amaré, Gunnar W. Reginsson, Pavol Cekan, Edwards, Thomas E., Snorri Th. Sigurdsson, Schiemann, Olav, Sigurdsson, Snorri, Thomas E. Edwards, Ferre D'Amare, Adrian R., Sandip A. Shelke   +13 more
core   +1 more source

crystIT: Complexity and Configurational Entropy of Crystal Structures via Information Theory

, 2020
The information content of a crystal structure as conceived by information theory has recently proved as an intriguing approach to calculate the complexity of a crystal structure within a consistent concept. Given the relatively young nature of the field,
Clemens, Kaußler, Gregor, Kieslich
core   +1 more source

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

Molecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen, Kristiane Søreng, Chiara Veroni, Laura Trachsel‐Moncho, Nagham Asp, Robin Gaupset, Lars Gustav Lyckander, Helene Knævelsrud, Lars Eftang, Anne Simonsen   +9 more
wiley   +1 more source

Complexes of Platinum(II) and Iridium(III) with Liquid Crystal and Luminescent Properties [PDF]

, 2010
This thesis is concerned with the search for luminescent metallomesogens, a class of materials that presents the combination of two different properties, luminescence (triplet emission) and liquid crystallinity. The motivation is two-fold.
Santoro, Amedeo
core  

Crystal Structure of Agaricus bisporus Mushroom Tyrosinase: Identity of the Tetramer Subunits and Interaction with Tropolone [PDF]

, 2011
Tyrosinase catalyzes the conversion of phenolic compounds into their quinone derivatives, which are precursors for the formation of melanin, a ubiquitous pigment in living organisms.
Dijkstra, B.W., Dijkstra, Bauke W., Weijn, A., Bauke W. Dijkstra, Amrah Weijn, Wangsa T. Ismaya, Ismaya, Wangsa T.,, Rozeboom, Henriette J.; id_orcid, Dijkstra, Bauke W.,, Rozeboom, H.J., Jurriaan J. Mes, Harry J. Wichers, Ismaya, Wangsa T., Weijn, Amrah,, Mes, J.J., Ismaya, W.T., Fusetti, F., Wichers, Harry J.,, Fabrizia Fusetti, Mes, Jurriaan J., Fusetti, Fabrizia,, Wichers, Harry J., Fusetti, Fabrizia, Mes, Jurriaan J.,, Wichers, H.J., Rozeboom, Henriette J., Henriëtte J. Rozeboom, Rozeboom, Henriëtte J.,, Weijn, Amrah   +28 more
core   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Photonic crystal interfaces: a design-driven approach

, 2006
Photonic Crystal structures have been heralded as a disruptive technology for the miniaturization of opto-electronic devices, offering as they do the possibility of guiding and manipulating light in sub-micron scale waveguides.
Ayre, Melanie
core  

Crystal Structure Of Bis(acetylacetonato)-bis(3-methylpyridine)-nickel(ii) Dihydrate, Ni(c6h7n)2(c5h 7o2)2 · 2h2o

, 2015
C22H32N2NiO6, triclinic, P1̄ (no. 2), a = 8.335(1) Å, b = 9.314(1) Å, c = 17.045(2) Å, α = 88.45(1)°, β = 82.12(1)°, γ = 70.296(9)°, V = 1233.7 Å3, Z = 2, Rgt(F) = 0.050, wRref(F2) = 0.177, T = 293 K.
Dunstan P.O., Caracelli I., Trindade A.C., Cussigh O., Zukerman-Schpector J.   +4 more
core   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source