Results 101 to 110 of about 4,947,350 (304)
Thin-film photonic crystal LEDs with enhanced directionality [PDF]
, 2009 The use of photonic crystals for light extraction from light-emitting diodes (LEDs) gives the possibility to shape the farfield emission pattern. This is of particular interest for étendue-limited LED applications that require a more directional ...
Bergenek, Krister +8 more
core +1 more source
The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer
Molecular Oncology, EarlyView.Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad +2 more
wiley +1 more source
Molecular Oncology, EarlyView.In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico +5 more
wiley +1 more source
Molecular Oncology, EarlyView.The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim +17 more
wiley +1 more source
Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation
Molecular Oncology, EarlyView.How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim +11 more
wiley +1 more source
The crystal structures of four dimethoxybenzaldehyde isomers
Acta Crystallographica Section E: Crystallographic Communications, 2019 The crystal structures of four dimethoxybenzaldehyde (C9H10O3) isomers, namely the 2,3-, 2,4-, 2,5- and 3,5- isomers, are reported and compared to the previously reported crystal structures of 3,4-dimethoxybenzaldehyde and 2,6-dimethoxybenzaldehyde.
Sander J. T. Brugman +5 more
doaj +1 more source
Polytypism of crystal structures
Computers & Mathematics with Applications, 1988 AbstractPolytypism occupies a singular position in the structural crystallography uniting features of polymorphism and diversity of crystal structure built of definite units. In the structural systematics the polytype structures are considered in relation to fragmentary, interstratified, hybrid (both commensurate and incommensurate), order-disorder (OD)
openaire +1 more source
, 2016 ‘Crystal structures’ describes the different types of close packing—hexagonal, cubic, face-centred cubic, and body-centred cubic—used to describe many simple inorganic structures, especially those of the elements.
A. M. Glazer
core +1 more source
Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer
Molecular Oncology, EarlyView.Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba +5 more
wiley +1 more source
Temperature Tunability of Dielectric/ Liquid Crystal / Dielectric Photonic Crystal Structures [PDF]
Journal of Optoelectronical Nanostructures, 2017 Recently, photonic crystals doped with liquid crystal (LC) material havegained much research interest. In this article new ternary one-dimensional photoniccrystal introduced and studied.
Ali Vahedi +1 more
doaj