Results 131 to 140 of about 280,213 (284)
Advanced Science, EarlyView.Reversible switching between “evident” (evident spin frustration, FR‐e) and “hidden” (hidden spin frustration, FR‐h) frustrated behavior is realized for the first time in spin‐intercalated layered magnets by regulating the competitive magnetic environment of JLL and JLS via solvent ad‐/desorption.
Qingxin Liu +3 more
wiley +1 more source
Progress on the Attenuation Mechanism and Modification of the Cobalt‐Free Spinel LiNi0.5Mn1.5O4
Advanced Science, EarlyView.This review provides an overview of the development history, working mechanisms, and scientific challenges of LiNi0.5Mn1.5O4 cathode materials for Lithium‐ion battery and discusses the strategies to improve the electrochemical performance of LiNi0.5Mn1.5O4.
Bao Zhang +11 more
wiley +1 more source
Hydrogen‐Deuterium Exchange Mass Spectrometry for Molecular Glue Characterization
Advanced Science, EarlyView.Molecular glues that stabilize protein–protein interactions are challenging to identify. Here, hydrogen‐deuterium exchange mass spectrometry can show and reveal gluing mechanisms that vary between protein binding partners. Abstract Molecular glues are powerful bioactive molecules that stabilize protein–protein interactions.
Danielle F. Kay +3 more
wiley +1 more source
Dimer‐Specific FokT‐seq Reveals DNA‐Binding Dimerization and Novel Genomic Targets of TDP‐43
Advanced Science, EarlyView.Loss of TDP‐43 dimerization is implicated in ALS, yet its mechanistic role remains elusive. This study introduces FokT, a novel system that restores TDP‐43 dimerization to map its DNA targets via FokT‐seq. The findings uncover key binding sites and offer a versatile tool for exploring dimer‐dependent transcriptional regulation.
Mingming Yang +4 more
wiley +1 more source
Isolation, X-ray Structures, and Electronic Spectra of Reactive Intermediates in Friedel−Crafts Acylations [PDF]
, 2005 Reactive intermediates in the Friedel−Crafts acylation of aromatic donors are scrutinized upon their successful isolation and X-ray crystallography at very low temperatures.
Davlieva, M. G. +3 more
core +1 more source
Mixed Lineage Kinase Domain‐Like Protein (MLKL): From Mechanisms to Therapeutic Opportunities
Advanced Science, EarlyView.The mixed lineage kinase domain‐like protein (MLKL) acts as the executioner in the necroptosis pathway, transitioning from an inactive to active state through phosphorylation, oligomerization, membrane recruitment, and membrane insertion, ultimately forming membrane hotpots.
Lijuan Xu, Chunlin Zhuang
wiley +1 more source
Biomolecular Interaction Prediction: The Era of AI
Advanced Science, EarlyView.This review offers a thorough examination of recent progress in deep learning for predicting biomolecular interactions, including those involving proteins, nucleic acids, and small molecules. It covers data processing strategies, representative model architectures, and evaluation metrics, while highlighting current methodological limitations.
Haoping Wang, Xiangjie Meng, Yang Zhang
wiley +1 more source
Modulation of Aging Diseases via RAGE Targets: A Dietary Intervention Review
Advanced Science, EarlyView.This paper analyzes RAGE ligand‐binding mechanisms and signaling, proposing intervention strategies targeting these interactions. It emphasizes dietary polyphenols, polysaccharides, and terpenoids delivered via functional foods for anti‐aging. These compounds offer long‐term, safe intervention through dietary supplementation, providing dual nutritional
Qian Wu +7 more
wiley +1 more source
Advanced Science, EarlyView.Inhalable eugenol (EUG) from clove oil attenuates NAFLD by activating hepatic olfactory receptor Olfr544, triggering cAMP/PKA/CREB signaling to enhance lipolysis/oxidation. EUG concurrently restores gut microbiota, enriching probiotics (L. reuteri XR23/L. johnsonii XR25) and metabolites (IPA/5‐HIAA) that suppress lipogenesis.
Xiao‐Ran Wang +15 more
wiley +1 more source