Results 221 to 230 of about 2,204,696 (317)
Conformational Trajectory of the Molecular Chameleon Grazoprevir from Formulation to Target‐Bound
Chemistry – A European Journal, EarlyView.ABSTRACT Macrocycles represent a promising class of beyond‐rule‐of‐5 (bRo5) therapeutics, capable of targeting proteins traditionally considered undruggable by conventional small molecules. Macrocycles exhibit intrinsic flexibility and often display a “chameleon‐like” ability to adapt to their environment, thereby enhancing their oral bioavailability ...
Lianne H. E. Wieske +5 more
wiley +1 more source
Dipolar Molecular Motor Candidates with Planar Chirality
Chemistry – A European Journal, EarlyView.Two prototypes of molecular motors with simultaneous implementation of planar chirality and a permanent dipole have been designed and synthesized in 7 steps with overall yields of 2.8 to 5.5%. Abstract Two molecular motor candidates built around ruthenium(II) centers featuring both planar chirality and a permanent dipole have been synthesized in seven ...
Thomas A. Hector +5 more
wiley +1 more source
A [3]Rotaxane Containing {Ti7Ga} Rings Linking CuII: Synthesis, Structure, and Spectroscopic Studies
Chemistry – A European Journal, EarlyView.Extended hybrid inorganic‐organic [2]‐ and [3]‐rotaxanes are reported based on heterometallic rings with threads that link CuII complexes; the crystal structures are reported, and the solution behavior is investigated by double electron electron resonance spectroscopy methods.
Selena J. Lockyer +7 more
wiley +1 more source
Chemistry – A European Journal, EarlyView.Staggered, square, and heavily bent dimers occur in the five known solvatomorphs of paddlewheel (PW) complex [PtVO(SOCPh)4]. These and other structural motifs are well within energetic reach due to the shallow potential energy surface that guides dimerization and are included in a revised classification of available structural data on heterobimetallic ...
Olga Mironova +3 more
wiley +1 more source
Physics-informed machine learning analysis for nanoscale grain mapping by synchrotron Laue microdiffraction. [PDF]
J Appl CrystallogrChan KH, Huang X, Tamura N, Chen X.
europepmc +1 more source
Chemistry – A European Journal, EarlyView.The study of the Diels–Alder reaction of cinnamaldehyde and cyclopentadiene, catalyzed by chiral imidazolidine‐4‐thiones, led to the discovery of a highly regio‐ and stereoselective Michael‐addition and consecutive ring closure. Here, the imidazolidine‐4‐thione not only catalytically activates cinnamaldehyde but also participates as the nucleophile to ...
Marian S. R. Ebeling +5 more
wiley +1 more source
Chemistry – A European Journal, EarlyView.One‐pot transition‐metal‐free methods for the synthesis of all three bonds of the alkyne's triple bond are reviewed. After analysis of several named reactions and discussion of improvements, recent advances in the synthesis of alkynes are discussed. Each section contains a proposed reaction mechanism and analysis of the strengths and weaknesses of the ...
Eugene Kim +4 more
wiley +1 more source
Twisted 1‐ and 2‐Azaperopyrenes: Synthesis, Structure, and Properties
Chemistry – A European Journal, EarlyView.ABSTRACT A synthesis of hitherto unknown 1‐ and 2‐azaperopyrenes, twisted nitrogen‐doped peropyrenes, is reported. The synthesis is based on a Brønsted acid‐mediated benzannulation of alkynes. Key alkyne intermediates are synthesized via two complementary routes, including a Pd/C‐catalyzed, copper‐ and amine‐free Sonogashira‐type coupling of (hetero ...
Ricardo Molenda +4 more
wiley +1 more source