Results 221 to 230 of about 2,064,816 (279)
Switching on Supramolecular DNA Junction Binding Using a Human Enzyme
Angewandte Chemie, EarlyView.Stimulus responsive control of DNA junction formation: Enzyme action cleaves flexible arms from a metallo‐supramolecular cylinder, transforming an inert metallo‐supramolecular structure into an active metallo‐supramolecular agent, and switching on its ability to assemble, bind and stabilize DNA three‐way junction structures.
Subhendu Karmakar +4 more
wiley +1 more source
An Artificial Metal‐Free Peroxidase Designed Using a Ferritin Cage for Bioinspired Catalysis
Angewandte Chemie, EarlyView.Designing artificial enzymes remains challenging due to the need for precise active site control. Here, we present a simple strategy to create metal‐free artificial enzymes by engineering Histidine clusters inside a ferritin cage. The resulting catalyst mimics peroxidase activity, and its stable cage structure offers new insights into supramolecular ...
Jiaxin Tian +4 more
wiley +1 more source
N‐Insertion of Diazonium Salts Into Ketone Derivatives
Angewandte Chemie, EarlyView.Diazonium salts insert into ketones and their silyl enol ethers through a sequence of α‐azenylation and ring expansion via an N‐iminoaziridinium species. Coupled with an efficient N‐N bond cleavage, this protocol offers a mild alternative to Beckmann rearrangements and a powerful tool for skeletal editing of ketones.
Mohammed Anif Pasha +3 more
wiley +1 more source
Angewandte Chemie, EarlyView.Ultrafast pump‐probe spectroscopies show that irradiation of a square Fe/Co Prussian blue analogue induces electron transfer within one Fe–Co subunit followed by fast spin crossover, and coupled equilibria between all states trigger a second electron transfer coupled to spin crossover in the other Fe–Co subunit on a ns timescale.
Jan‐Hendrik Borter +8 more
wiley +1 more source
Structural Basis for the Catalytic Mechanism of ATP‐Dependent Diazotase CmaA6
Angewandte Chemie, EarlyView.Several diazotases have been reported in recent years, but the detailed catalytic mechanism is unclear. From X‐ray crystallography and Cryo‐EM analysis, we obtained the structure of a diazotase CmaA6, which synthesizes 3‐diazocoumaric acid. Kinetic analysis and computational analysis indicated that CmaA6 catalyzes diazotization via an unprecedented ...
Seiji Kawai +5 more
wiley +1 more source
Angewandte Chemie, EarlyView.We report rearrangement and functionalisation chemistry at silicon facilitated by reductive ligand migration and Si(II)/Si(IV) redox shuttling. Abstract Spontaneous redox shuttling at silicon is very rare, primarily reflecting the thermodynamic challenges associated with reduction processes for lighter p‐block elements.
Jianqin Tang +4 more
wiley +1 more source
Enhancing Cold Adaptation of Bidomain Amylases by High‐Throughput Computational Engineering
Angewandte Chemie, EarlyView.This work uncovers molecular determinants of cold adaptation in bidomain amylases by combining MD simulations and biochemical assays, revealing that increased domain separation drives enhanced activity at low temperatures. Guided by this principle, high‐throughput in silico linker screening of mesophilic psA was performed, yielding variant psA121 with ...
Ning Ding +6 more
wiley +1 more source
Angewandte Chemie, EarlyView.The first kinetic resolution of allenylic alcohols by asymmetric allenylic substitution has been achieved, which was enabled by the design of a new chiral ligand that altered the energetic profiles of the previously established pathways. Both secondary and tertiary alcohols were suitable substrates.
Youshao Tu +4 more
wiley +1 more source