Results 41 to 50 of about 184,229 (279)

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

FEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas, Brigitta Maruzs, Zsófia E. Kálmán, Tomas Klumpler, Gyula Batta, Bálint Péterfia, Zoltán Gáspári   +6 more
wiley   +1 more source

X-ray structure of a putative reaction intermediate of 5-aminolaevulinic acid dehydratase [PDF]

, 2003
The X-ray structure of yeast 5-aminolaevulinic acid dehydratase, in which the catalytic site of the enzyme is complexed with a putative cyclic intermediate composed of both substrate moieties, has been solved at 0.16 nm (1.6 Å) resolution.
Youell, J.H., Butler, D., Cooper, J.B., Erskine, P.T., Warren, M.J., Brindley, A.A., Shoolingin-Jordan, P.M., Wood, S.P., Coates, L.   +8 more
core   +1 more source

Crystal structure and Hirshfeld surface analysis of a chalcone derivative: (E)-3-(4-fluorophenyl)-1-(4-nitrophenyl)prop-2-en-1-one

Acta Crystallographica Section E: Crystallographic Communications, 2019
The molecular structure of the title chalcone derivative, C15H10FNO3, is nearly planar and the molecule adopts a trans configuration with respect to the C=C double bond.
Qin Ai Wong, Tze Shyang Chia, Huey Chong Kwong, C. S. Chidan Kumar, Ching Kheng Quah, Md. Azharul Arafath   +5 more
doaj   +1 more source

Phosphoinositides and inositol phosphates as molecular glues

FEBS Letters, EarlyView.
Inositol phosphates (IPs) and phosphoinositides (PIPs) regulate diverse eukaryotic processes. Beyond recruiting signaling proteins or acting as structural cofactors, recent studies suggest they mediate protein–protein interactions as natural molecular glues.
Aleshia Seaton‐Terry, Alexander J. Cutright, Mong Na Claire Loi, Jessica Martin, Joseph W. Gilligan, Jakub N. Kubina, Michael J. Arambula, Susanna Tanada Palmu, Daniella Zhou, Raymond D. Blind   +9 more
wiley   +1 more source

Structural characterization of Ni-containing metalloenzymes from archaea by X-ray crystallography and transmission electron microscopy [PDF]

, 2019
In der vorliegenden Arbeit werden zwei Enzymsysteme – Ni-haltige Kohlenmonoxid-Dehydrogenase (CODH) und [NiFe]-haltige Hydrogenase – strukturell untersucht. Im 1. Teil werden die Untersuchungen des ACDS-Komplexes aus A.
Ilina, Yulia
core   +1 more source

N-{(Z)-3-Oxo-3-[(E)-(pyridin-2-ylmethyl)diazenyl]-1-(thiophen-2-yl)prop-1-en-2-yl}benzamide

IUCrData, 2016
In the title compound, C20H16N4O2S, the thiophene ring subtends dihedral angles of 58.6 (3) and 9.8 (3)° with the benzamide and pyridine rings, respectively, whereas these two rings are inclined to one another by 59.3 (3)°. There is an intramolecular C—H.
Devinder K. Sharma, K. N. Subbulakshmi, B. Narayana, B. K. Sarojini, Sumati Anthal, Rajni Kant   +5 more
doaj   +1 more source

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

FEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source

Site-directed mutagenesis and X-ray crystallography of two phospholipase A2 mutants: Y52F and Y73F [PDF]

, 1992
Tyr52 and Tyr73 are conserved amino acid residues throughout all vertebrate phospholipases A2. They are part of an extended hydrogen bonding system that links the N-terminal α-NH3+-group to the catalytic residues His48 and Asp99.
Drenth, Jan,, Haas, Gerard H. de, Thunnissen, Marjolein M.G.M., Drenth, Jan, Verheij, Hubertus M., Franken, Peet A., Dijkstra, Bauke W., Franken, Peet A.,, Kalk, Kor H., Kalk, Kor H.,, Thunnissen, Marjolein M.G.M.,, Haas, Gerard H. de,, Dijkstra, Bauke W.,, Verheij, Hubertus M.,   +13 more
core   +1 more source

Combined scanning small-angle X-ray scattering and holography probes multiple length scales in cell nuclei [PDF]

, 2022
X‐rays are emerging as a complementary probe to visible‐light photons and electrons for imaging biological cells. By exploiting their small wavelength and high penetration depth, it is possible to image whole, intact cells and resolve subcellular ...
Cassini, Chiara, Denz, Manuela, Osterhoff, Markus, Hagemann, Johannes, Cassini, Chiara; 1Institute for X-Ray Physics, University of Göttingen, Friedrich-Hund-Platz 1, 37077Göttingen, Germany, Salditt, Tim; 1Institute for X-Ray Physics, University of Göttingen, Friedrich-Hund-Platz 1, 37077Göttingen, Germany, Töpperwien, Mareike; 1Institute for X-Ray Physics, University of Göttingen, Friedrich-Hund-Platz 1, 37077Göttingen, Germany, Wittmeier, Andrew, Salditt, Tim, Köster, Sarah, Wittmeier, Andrew; 1Institute for X-Ray Physics, University of Göttingen, Friedrich-Hund-Platz 1, 37077Göttingen, Germany, Denz, Manuela; 1Institute for X-Ray Physics, University of Göttingen, Friedrich-Hund-Platz 1, 37077Göttingen, Germany, Osterhoff, Markus; 1Institute for X-Ray Physics, University of Göttingen, Friedrich-Hund-Platz 1, 37077Göttingen, Germany, Hagemann, Johannes; 1Institute for X-Ray Physics, University of Göttingen, Friedrich-Hund-Platz 1, 37077Göttingen, Germany, Töpperwien, Mareike   +14 more
core   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source