Results 51 to 60 of about 6,874,902 (263)

Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation

Molecular Oncology, EarlyView.
How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim, Alvin Kunyao Guo, Yoko Itahana, Srinivasaraghavan Kannan, Valerie Goh, Mingmin Ong, Terina Yan Wen Tay, Weiying Ye, Sabhashina Radha Krishnan, Jun Nishiyama, Chandra S Verma, Koji Itahana   +11 more
wiley   +1 more source

Ligand Binding to Chicken Liver Basic Fatty acid-Binding Protein. An X-ray Crystallography Study

, 2004
Ligand Binding to Chicken Liver Basic Fatty acid-Binding Protein.
BOVI, Michele, M. E. Carrizo, GUARIENTO, Mara, PERDUCA, Massimiliano, CAPALDI, Stefano, MONACO, Ugo Luigi   +5 more
core   +1 more source

3D-printed holders for fixed-target serial X-ray crystallography. [PDF]

, 2020
The in meso in situ serial X-ray crystallography method was developed to ease the handling of small fragile crystals of membrane proteins and for rapid data collection on hundreds of microcrystals directly in the growth medium without the need for ...
Wang, Meitian, Meier, Nathalie, Olieric, Vincent, Huang, Chia-Ying, Caffrey, Martin, Wang, Meitian (author), Meier, Nathalie (author), Caffrey M, Wang M, Olieric, Vincent (author), Olieric V, Huang, Chia-Ying (author), Caffrey, Martin (author), Huang CY, Meier N   +14 more
core   +1 more source

The C‐terminal domain of yeast Arginyltransferase1 is essential for its catalytic activity

FEBS Open Bio, EarlyView.
Arginyltransferase 1 (Ate1), a eukaryotic enzyme, catalyses arginylation, transferring arginine from tRNA‐Arg to the amino terminus of the target protein. Overexpression of Ate1 in yeast is lethal and is dependent on arginylation. This study elucidates how mutations in the cofactor‐binding and active site of Ate1 and truncation of its structural ...
Vikas Kumar Yadav, Shweta Shweta, Manisha Malhotra, Vikash Maurya, Akhilesh Kumar   +4 more
wiley   +1 more source

The structure of coordination precursors as an effective tool for governing of size and morphology of ZnS and ZnO nanoparticles

Journal of Saudi Chemical Society, 2018
The zinc sulphide and zinc oxide micro- and nanoparticles of different shapes were synthesized from the five zinc coordination precursors, via controlled thermal decomposition process.
Rafal Kruszynski, Marcin Swiatkowski
doaj   +1 more source

High‐Temperature Phase Transformation in a V‐9Si‐6.5B Alloy: The Kinetic and Crystallographic Pathway From V5SiB2 to V8SiB4

Advanced Engineering Materials, EarlyView.
In situ synchrotron high‐energy X‐ray diffraction reveals the real‐time high‐temperature phase evolution of a ternary V‐9Si‐6.5B alloy. The study uncovers a kinetically delayed V5SiB2 → V8SiB4 transformation governed by massive structural and chemical barriers.
Zahra Sabeti, Andreas Stark, Roja Rani Korrayi, Florian Pyczak, Georg Hasemann   +4 more
wiley   +1 more source

Distinct Microstructural Characteristic Lengths Defining Notch Fatigue Crack Initiation and Propagation, and Defect Tolerance in Advanced Steels

Advanced Engineering Materials, EarlyView.
Schematic representation of modes of microcrack nucleation, growth and temporary arrestment at different boundaries, with the criteria for crack propagation in three scenarios: (1) large notch, (2) defect/small sharp notch, and (3) long crack. This work revisits and integrates results on the fatigue behavior of advanced bainitic steels (in particular ...
Lucia Morales‐Rivas
wiley   +1 more source

Impact of Homocyclic and Heterocyclic Rings of Chalcones on Charge Transfer Behaviour: A Nonlinear Optical Study

Chemical Physics Impact
This paper presents the effects of incorporating thienyl and phenyl rings as the terminal ring in the cinnamoyl counterparts of chalcones with donor-acceptor-donor (D-A-D) push-pull setting, on their photophysical responses.
Nur Aisyah Mohamad Daud, Qin Ai Wong, Bi Sheng Ooi, Ching Kheng Quah, Farah Diana Ramzi, Yip-Foo Win, Parutagouda Shankaragouda Patil   +6 more
doaj   +1 more source

Structural Chemistry of Halide including Thallides A8Tl11X1−n (A = K, Rb, Cs; X = Cl, Br; n = 0.1–0.9)

Crystals, 2018
A8Tl11 (A = alkali metal) compounds have been known since the investigations of Corbett et al. in 1995 and are still a matter of current discussions as the compound includes one extra electron referred to the charge of the Tl117− cluster.
Stefanie Gärtner, Susanne Tiefenthaler, Nikolaus Korber, Sabine Stempfhuber, Birgit Hischa   +4 more
doaj   +1 more source

Investigating the Effect of Inclination Angle and the Influence of Scan Parameters on the Appearance and Thermal and Mechanical Properties of Filigree Tension Rods of LPBF‐Manufactured NiTi Shape‐Memory Alloys

Advanced Engineering Materials, EarlyView.
This article investigates the dependence of the properties on the manufacturing orientation in the form of the inclination angle to the build plate of LPBF‐fabricated NiTi rods with a diameter of 150–220 µm. Metallographic, chemical, thermal, and mechanical characterization show behavior under identical manufacturing conditions that ranges from ...
Sandra Herzig, Michael Werner, Christian Rotsch   +2 more
wiley   +1 more source