Results 151 to 160 of about 412,410 (289)

A Synergistic Inhibitor Development Strategy Against Human UDP‐Galactose‐4‐Epimerase

Angewandte Chemie International Edition, EarlyView.
The epimerase GalE is crucial for the biosynthesis of cancer‐relevant O‐GalNAc glycans. Here, we employ orthogonal, structurally enabled small molecule fragment screens to yield both covalent and non‐covalent inhibitors against GalE within no more than 22 elaborated compounds.
William M. Browne, Jonathan Pettinger, Teresa Weckwerth, Andrew Purkiss, Sing Hei Lok, Louisa Penicaut, Roksana Ogrodowicz, Raveena Prema, Simone Kunzelmann, Chloe Roustan, Ganka Bineva‐Todd, Saskia Pieters, Francesca Zappacosta, Alfred E. Doherty, Isobel Oram, Christelle Soudy, Robert Quinlan, Joanna Redmond, Svend Kjaer, David House, Stephane Mouilleron, Jacob T. Bush, Benjamin Schumann   +22 more
wiley   +1 more source

Protein Structure Determination by Racemic and Quasi-Racemic X-Ray Crystallography. [PDF]

Chembiochem
Kent SBH.
europepmc   +1 more source

Ribozymes for RNA‐Catalyzed RNA Methylation and Labeling

Angewandte Chemie International Edition, EarlyView.
Ribozymes are powerful tools for site‐specific RNA modification. Their activities range from installing tags and fluorophores to generating natural RNA methylations, making them valuable tools to uncover the many functions that RNA plays in nature.
Carolin P. M. Scheitl, Claudia Höbartner   +1 more
wiley   +1 more source

3D ED: Accessible, robust and accurate. [PDF]

IUCrJ
Kodjikian S.
europepmc   +1 more source

Erratum: The crystal structure of dypingite: understanding the long-range disorder. Corrigendum. [PDF]

J Appl Crystallogr
Sednev-Lugovets A, Lu Y, Vistad Ø, Carvalho PA, Missyul A, Austrheim H, Friis H, Guzik MN.   +7 more
europepmc   +1 more source

An All in one Sample Holder for Macromolecular X ray Crystallography with Minimal Background Scattering [PDF]

, 2019
Feiler, C.G., Wallacher, D., Weiss, M.S.
core   +2 more sources

Common misconceptions in crystallography and crystal optics. [PDF]

J Appl Crystallogr
Casas L.
europepmc   +1 more source

Unlocking Catalyst Activation as a Critical Bottleneck in Cross‐Coupling Reactions: Room‐Temperature Couplings of Weak Nucleophiles Enabled by [Pd(1‐MeNAP)TFA]2 Precatalysts

Angewandte Chemie International Edition, EarlyView.
In many Pd‐catalyzed cross‐couplings, catalyst performance has been found to be limited by catalyst activation. Methylnaphthyl (MeNAP) palladium trifluoroacetate dimers are presented as easy‐to‐store and easy‐to‐handle precursors, which rapidly activate under reaction conditions, even when only weakly coordinating, non‐reducing nucleophiles are present.
Sourav Manna, Henric F. Janning, Nikolaos V. Tzouras, Jane Anto Simplica Sagayaraj, Fadil Faizal Mannighayil, Angelino Doppiu, Lukas J. Gooßen   +6 more
wiley   +1 more source

Decision-making in serial crystallography: a simple test to quickly determine whether sufficient data have been collected. [PDF]

Acta Crystallogr D Struct Biol
von Stetten D, Pearson AR.
europepmc   +1 more source

50th anniversary of the Stanford SSRL synchrotron radiation and protein crystallography initiative. [PDF]

J Synchrotron Radiat
Helliwell JR, Nave C, Szebenyi DM.
europepmc   +1 more source