Results 161 to 170 of about 662,036 (283)

Breakthrough Design of Highly Potent Antivirals Against Wild‐Type HIV‐1 and Lenacapavir‐Resistant M66I Variant

Angewandte Chemie, EarlyView.
Lenacapavir, the first‐in‐class drug targeting HIV‐1 capsid, is a breakthrough drug in HIV‐1 treatment and prophylaxis. However, a single M66I mutation confers complete viral resistance to lenacapavir. We report herein the design and synthesis of innovative R2 analogs demonstrating low nM potency against HIV‐1 M66I and excellent pharmacokinetics in ...
Nicolas Jamey, D. M. Nirosh Udayanga, Huanchun Zhang, Roshan Katekar, Wei Xie, Shreya M. Ravichandran, Xinyong Cai, Zachary C. Lorson, William M. McFadden, Won Hee Ryu, Jiashu Xie, Karen A. Kirby, Stefan G. Sarafianos, Zhengqiang Wang   +13 more
wiley   +2 more sources

Extending Small‐Molecule Aptamer Discovery Principles to Protein Targets: Selection and Characterization of Green Fluorescent Protein Aptamers

Angewandte Chemie, EarlyView.
Protein‐binding aptamers remain poorly understood compared to their small‐molecule counterparts. Using green fluorescent protein (GFP) variants as a tractable model system, we show how subtle changes in protein surface composition and divalent metal ions reshape aptamer selection, specificity, and binding.
Stefen Stangherlin, Nathan Wong, Logan Fanning, Kate Kim, Peter Kim, Iffat Tabassum, Songyang Miao, Rui Huang, Juewen Liu   +8 more
wiley   +2 more sources

ECS1@IYCr2014: Conveying a vision of modern crystallography

, 2014
ECS1@IYCr2014: Conveying a vision of modern crystallography Roberta Oberti, Serena Tarantino, Michele Zema, Marco Milanesio, Rita Berisio, Anna Moliterni, Carlo Mealli The first edition of the ECA European Crystallography School (ECS1), to be held in ...
BERISIO, MOLITERNI, A, R, TARANTINO S, MEALLI C, OBERTI R, ZEMA M, MILANESIO, M   +9 more
core  

Switching ATP‐Forming Phosphoryl‐Transfer Chemistry With a Restricted Set of Amino Acids

Angewandte Chemie, EarlyView.
Constraints on amino acid composition relevant to prebiotic chemistry reshape enzyme chemistry by replacing the canonical mechanism within a conserved protein fold with a distinct ATP‐forming reaction, ADP disproportionation. Such constraints generate alternative catalytic solutions not observed in modern enzymes and point to chemically plausible early
Sota Yagi, Subrata Dasgupta, Shunsuke Tagami, Satoshi Akanuma   +3 more
wiley   +2 more sources

Hydrogen‐Bonding Order Associated With Radical Delocalization in Layered Organic Cathode Materials

Angewandte Chemie, EarlyView.
“TAQ” and TAPT share the same pyrazine‐based molecular structure but differ in degree of crystallinity. Combined x‐ray scattering, solid‐state NMR, MicroED, and EPR reveal that “TAQ”'s higher crystallinity and ordered hydrogen‐bonding network are associated with enhanced radical delocalization and conductivity, highlighting structural order as a design
Alae Eddine Lakraychi, Zeqian Zhang, Oliver Lin, Eric D Walter, Jiaqi Wang, Harshan Reddy Gopidi, Eliot F. Woods, Ruozhu Feng, Wei Wang, Pieremanuele Canepa, Brett A. Helms, Kamila M. Wiaderek, Qian Chen, Yan Yao, Ying Chen   +14 more
wiley   +2 more sources

Time‐Resolved Multidimensional NMR Spectroscopy Reveals the Bifurcated Folding Pathway of a Thrombin‐Binding DNA G4–Azobenzene Derivative Complex

Angewandte Chemie, EarlyView.
A photoswitchable ligand was used to trigger conformational changes within the thrombin binding aptamer DNA G‐Quadruplex. These reversible ligand driven rearrangements were examined by time‐resolved NMR experiments to gain insight of the dynamic folding landscape of the G‐quadruplex.
Jason Martins, Julia Wirmer‐Bartoschek, Harald Schwalbe   +2 more
wiley   +2 more sources

Photoswitchable Ambiphilicity: Light‐Gated Frustrated Lewis Pair Reactivity and Z‐Type Interaction

Angewandte Chemie, EarlyView.
Light‐controlled ambiphilicity is realized in photoswitchable intramolecular phosphorus/boron Lewis pairs. Reversible switching modulates both the thermodynamics and kinetics of frustrated Lewis‐pair reactivity, enabling light‐gated CO2 binding and release.
Lennart Stoess, Emil L. M. Paulin, Fabian Michel, Lutz Greb   +3 more
wiley   +2 more sources

In Vitro Selection of Functional Neoproteins Containing Highly Fluorinated Cores

Angewandte Chemie, EarlyView.
The generation of neoproteins—functional proteins containing unnatural amino acids—is a key goal in synthetic biology. We develop a platform to discover neoproteins with specified bioactivity from trillion‐member sequence libraries, using genetic code reprogramming, in vitro selection and microwave peptide synthesis.
Adam Beattie, Alexander Vinogradov, Chikako Okada, Toru Sengoku, Takayuki Katoh, Hiroaki Suga   +5 more
wiley   +2 more sources

Helle Zinnhalogenidperowskit Quantenpunkte durch Kompensationsdotierung mit Organischen Dikationen

Angewandte Chemie, EarlyView.
Zinnhalogenidperowskite (ZHP) sind attraktive Nah‐Infrarotemitter. Quanteneingeschlossene ZHP Quantenpunkte (QP) zeigen jedoch geringe Emissivität und Intrabandübergänge aufgrund von Selbstdotierung. Wir präsentieren aliovalente Substitution von Cäsium durch organische Dikationen als Kompensationsstrategie zur Anhebung des Ferminiveaus ...
Ole F. Dressler, Paul Golias, John L. Lyons, Stefanie Frick, Sebastian Siol, Sure Ceylan, Sebastian Sabisch, Luca V. Comparetto, Louis Rohrer, Lidiia Dubenska, Amrutha Rajan, Maksym V. Kovalenko   +11 more
wiley   +1 more source

Structure and Function of a Multi‐Megadalton Virus‐Like Proteolytic Dodecahedron

Angewandte Chemie, EarlyView.
Zuzalysin, a virulence metallopeptidase of the periodontal pathogen Porphyromonas gingivalis, is secreted as a latent, flexible ≈95‐kDa monomer. Calcium triggers cysteine‐switch activation and hierarchical assembly into pentamers, bipentamers, tripentamers, and a ≈5.6‐MDa, ≈355‐Å dodecahedron. Structures at 1.8–3.6 Å reveal a virus‐sized catalytic cage
Mariusz Madej, Arturo Rodríguez‐Banqueri, Danuta Mizgalska, Borys Szmigielski, Zuzanna Nowakowska, Małgorzata Benedyk‐Machaczka, Monika Bzowska, Katarzyna Mikruta, Juan Sebastián Ramírez‐Larrota, Chinanu Agunanne, Olivier Julien, Anthony J. O'Donoghue, Carsten Scavenius, Mario López‐Martín, Enrique Marcos, Łukasz Koziej, Sebastian Glatt, Pablo Guerra, Ulrich Eckhard, Jan Potempa, F. Xavier Gomis‐Rüth   +20 more
wiley   +2 more sources